N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 43, 2015, Pages 13318-13323

  Jin, Niyun ^a,b,c   Wang, Yang ^b   Crawford, Frances ^a,b   White, Janice ^b   Marrack, Philippa ^a,b,d   Dai, Shaodong ^b,d   Kappler, John W ^a,b,c,d  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO DENVER   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen processing; Autoimmunity; Crystallography; Posttranslational modification; Transpeptidation

Indexed keywords

AUTOANTIGEN; CHROMOGRANIN A; PEPTIDE; TETRAMER; UNCLASSIFIED DRUG; WE14 PEPTIDE; EPITOPE; INTERLEUKIN 2; PEPTIDE FRAGMENT; WE14 PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREATIC LYMPH NODE; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROCESSING; T LYMPHOCYTE ACTIVATION; AMINO ACID SEQUENCE; ANIMAL; BACULOVIRIDAE; CHEMISTRY; CRYSTALLIZATION; FLOW CYTOMETRY; GENETICS; HYBRIDOMA; IMMUNOLOGY; MOLECULAR GENETICS; MOLECULAR MODEL; NONOBESE DIABETIC MOUSE; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BACULOVIRIDAE; BASE SEQUENCE; CHROMOGRANIN A; CRYSTALLIZATION; DIABETES MELLITUS, TYPE 1; EPITOPES; FLOW CYTOMETRY; HYBRIDOMAS; INTERLEUKIN-2; MICE; MICE, INBRED NOD; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84945976228     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1517862112     Document Type: Article

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