Cutting edge: Vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice

Journal of Immunology

Volumn 186, Issue 7, 2011, Pages 3831-3835

  Nikoopour, Enayat ^a,b   Sandrock, Christian ^a,b   Huszarik, Katrina ^a,b   Krougly, Olga ^a,b   Lee Chan, Edwin ^a,b   Masteller, Emma L ^c,d   Bluestone, Jeffrey A ^c,d   Singh, Bhagirath ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTYLTHREONYLLYSYLVALYLMETHIONYLLYSYLCYSTEINYLVALYLLEUCYLGLUTAMYLVALYLISOLEUCYLSERYLASPARTIC ACID; AUTOANTIGEN; B LYMPHOCYTE ANTIGEN; CHROMOGRANIN A; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VASOSTATIN 1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BDC2.5 T LYMPHOCYTE; CELL CLONE; CONTROLLED STUDY; DIABETES MELLITUS; IMMUNE RESPONSE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; SCID MOUSE; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENE; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; CELL PROLIFERATION; CELLS, CULTURED; CHROMOGRANIN A; DIABETES MELLITUS, TYPE 1; EPITOPES, T-LYMPHOCYTE; HUMANS; ISLETS OF LANGERHANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS;

EID: 79955029027     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003617     Document Type: Article

References (15)

1. Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD. Immunity 7: 727-738. (Pubitemid 28064887)
2. Dobbs, C., and K. Haskins. 2001. Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical. J. Immunol. 166: 2495-2504. (Pubitemid 32173486)
3. + islet-specific T cell clone. Science 249: 1433-1436.
4. Burton, A. R., E. Vincent, P. Y. Arnold, G. P. Lennon, M. Smeltzer, C. S. Li, K. Haskins, J. Hutton, R. M. Tisch, E. E. Sercarz, et al. 2008. On the pathogenicity of autoantigen-specific T-cell receptors. Diabetes 57: 1321-1330.
5. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089-1100. (Pubitemid 23289465)
6. Haskins, K. 2005. Pathogenic T-cell clones in autoimmune diabetes: More lessons from the NOD mouse. Adv. Immunol. 87: 123-162. (Pubitemid 41133493)
7. Judkowski, V., C. Pinilla, K. Schroder, L. Tucker, N. Sarvetnick, and D. B. Wilson. 2001. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J. Immunol. 166: 908-917. (Pubitemid 32060245)
8. Yoshida, K., T. Martin, K. Yamamoto, C. Dobbs, C. Münz, N. Kamikawaji, N. Nakano, H. G. Rammensee, T. Sasazuki, K. Haskins, and H. Kikutani. 2002. Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones. Int. Immunol. 14: 1439-1447. (Pubitemid 36024610)
9. Stadinski, B. D., T. Delong, N. Reisdorph, R. Reisdorph, R. L. Powell, M. Armstrong, J. D. Piganelli, G. Barbour, B. Bradley, F. Crawford, et al. 2010. Chromogranin A is an autoantigen in type 1 diabetes. Nat. Immunol. 11: 225-231.
10. Helle, K. B. 2010. Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system. Results Probl. Cell Differ. 50: 21-44.
11. Suri, A., and E. R. Unanue. 2005. The murine diabetogenic class II histocompatibility molecule I-Ag7: Structural and functional properties and specificity of peptide selection. Adv. Immunol. 88: 235-265. (Pubitemid 41437916)
12. + T cell-specific epitopes of islet-specific glucose-6- phosphatase catalytic subunit-related protein: A novel beta cell autoantigen in type 1 diabetes. J. Immunol. 174: 5306-5315. (Pubitemid 40593169)
13. Masteller, E. L., M. R. Warner, W. Ferlin, V. Judkowski, D. Wilson, N. Glaichenhaus, and J. A. Bluestone. 2003. Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. J. Immunol. 171: 5587-5595. (Pubitemid 37432850)
14. Harrison, L. C., M. C. Honeyman, S. Trembleau, S. Gregori, F. Gallazzi, P. Augstein, V. Brusic, J. Hammer, and L. Adorini. 1997. A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J. Exp. Med. 185: 1013-1021. (Pubitemid 27136794)
15. Stadinski, B., J. Kappler, and G. S. Eisenbarth. 2010. Molecular targeting of islet autoantigens. Immunity 32: 446-456.