MiR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Song, Ge ^a   Wang, Renjie ^a   Guo, Junfei ^a   Liu, Xuyuan ^a   Wang, Fang ^a   Qi, Ying ^a   Wan, Haiying ^a   Liu, Min ^a   Li, Xin ^a   Tang, Hua ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; ARGONAUTE PROTEIN; EIF2C2 PROTEIN, HUMAN; GRSF1 PROTEIN, HUMAN; MICRORNA; MIRN138 MICRORNA, HUMAN; MIRN346 MICRORNA, HUMAN; POLYADENYLIC ACID BINDING PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL; BAGG ALBINO MOUSE; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; HUMAN; NUDE MOUSE; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ANIMALS; ARGONAUTE PROTEINS; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; POLY(A)-BINDING PROTEINS; TELOMERASE;

EID: 84945931100     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15793     Document Type: Article

References (43)

1. Ameres, S. L. and Zamore, P. D. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol 14, 475-488 (2013).
2. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
3. Friedman, R. C., Farh, K. K., Burge, C. B. and Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19, 92-105 (2009).
4. Kosik, K. S. MicroRNAs and cellular phenotypy. Cell 143, 21-26 (2010).
5. Di Leva, G., Garofalo, M. and Croce, C. M. MicroRNAs in cancer. Annual review of pathology 9, 287-314 (2014).
6. Leung, A. K. and Sharp, P. A. MicroRNA functions in stress responses. Mol Cell 40, 205-215 (2010).
7. Farazi, T. A., Hoell, J. I., Morozov, P. and Tuschl, T. MicroRNAs in human cancer. Advances in experimental medicine and biology 774, 1-20 (2013).
8. Jiao, A. L. and Slack, F. J. RNA-mediated gene activation. Epigenetics: official journal of the DNA Methylation Society 9, 27-36 (2013).
9. Patil, V. S., Zhou, R. and Rana, T. M. Gene regulation by non-coding RNAs. Critical reviews in biochemistry and molecular biology 49, 16-32 (2014).
10. Morris, K. V., Santoso, S., Turner, A. M., Pastori, C. and Hawkins, P. G. Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. PLoS genetics 4, e1000258 (2008).
11. Vasudevan, S., Tong, Y. and Steitz, J. A. Switching from repression to activation: microRNAs can up-regulate translation. Science 318, 1931-1934 (2007).
12. Place, R. F., Li, L. C., Pookot, D., Noonan, E. J. and Dahiya, R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA 105, 1608-1613 (2008).
13. Kang, H. W. et al. miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells. FEBS Lett 586, 897-904 (2012).
14. Zhang, L. Y., Liu, M., Li, X. and Tang, H. miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). J Biol Chem 288, 4035-4047 (2013).
15. Peter, M. E. Targeting of mRNAs by multiple miRNAs: the next step. Oncogene 29, 2161-2164 (2010).
16. Cimmino, A. et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102, 13944-13949 (2005).
17. Shay, J. W. and Wright, W. E. Role of telomeres and telomerase in cancer. Semin Cancer Biol 21, 349-353 (2011).
18. Smith, L. L., Coller, H. A. and Roberts, J. M. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 5, 474-479 (2003).
19. Ghosh, A. et al. Telomerase directly regulates NF-kappaB-dependent transcription. Nat Cell Biol 14, 1270-1281 (2012).
20. Hanahan, D. and Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
21. Jaitner, S. et al. Human telomerase reverse transcriptase (hTERT) is a target gene of beta-catenin in human colorectal tumors. Cell Cycle 11, 3331-3338 (2012).
22. Wu, K. J. et al. Direct activation of TERT transcription by c-MYC. Nat Genet 21, 220-224 (1999).
23. Low, K. C. and Tergaonkar, V. Telomerase: central regulator of all of the hallmarks of cancer. Trends in biochemical sciences 38, 426-434 (2013).
24. Ufer, C. The biology of the RNA binding protein guanine-rich sequence binding factor 1. Current protein and peptide science 13, 347-357 (2012).
25. Jablonski, J. A. and Caputi, M. Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity. J Virol 83, 981-992 (2009).
26. Kash, J. C. et al. Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis. J Virol 76, 10417-10426 (2002).
27. Park, Y. W., Wilusz, J. and Katze, M. G. Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1. Proc Natl Acad Sci USA 96, 6694-6699 (1999).
28. Antonicka, H., Sasarman, F., Nishimura, T., Paupe, V. and Shoubridge, E. A. The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. Cell Metab 17, 386-398 (2013).
29. Jourdain, A. A. et al. GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metab 17, 399-410 (2013).
30. Mitomo, S. et al. Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines. Cancer Sci 99, 280-286 (2008).
31. Ingolia, N. T., Brar, G. A., Rouskin, S., McGeachy, A. M. and Weissman, J. S. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nature protocols 7, 1534-1550 (2012).
32. Rosa, M. I. et al. Accuracy of telomerase in cervical lesions: a systematic review. International journal of gynecological cancer: official journal of the International Gynecological Cancer Society 17, 1205-1214 (2007).
33. Zhou, J., Ding, D., Wang, M. and Cong, Y. S. Telomerase reverse transcriptase in the regulation of gene expression. BMB reports 47, 8-14 (2014).
34. Bhattacharyya, S. N., Habermacher, R., Martine, U., Closs, E. I. and Filipowicz, W. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 125, 1111-1124 (2006).
35. Orom, U. A., Nielsen, F. C. and Lund, A. H. MicroRNA-10a binds the 5' UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell 30, 460-471 (2008).
36. Tsai, N. P., Lin, Y. L. and Wei, L. N. MicroRNA mir-346 targets the 5-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression. The Biochemical journal 424, 411-418 (2009).
37. Zhang, X. et al. MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation. Cell 158, 607-619 (2014).
38. Hwang, H. W., Wentzel, E. A. and Mendell, J. T. A hexanucleotide element directs microRNA nuclear import. Science 315, 97-100 (2007).
39. Eiring, A. M. et al. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 140, 652-665 (2010).
40. Rissland, O. S., Hong, S. J. and Bartel, D. P. MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes. Mol Cell 43, 993-1004 (2011).
41. Kedde, M. et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 131, 1273-1286 (2007).
42. Ufer, C. et al. Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development. Genes Dev 22, 1838-1850 (2008).
43. Guo, H., Ingolia, N. T., Weissman, J. S. and Bartel, D. P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-840 (2010).