-
1
-
-
25844524877
-
Neurodegenerative diseases: An overview of environmental risk factors
-
Brown, R. C., Lockwood, A. H. & Sonawane, B. R. Neurodegenerative diseases: an overview of environmental risk factors. Environ. Health Perspect. 113, 1250-1256 (2005).
-
(2005)
Environ. Health Perspect.
, vol.113
, pp. 1250-1256
-
-
Brown, R.C.1
Lockwood, A.H.2
Sonawane, B.R.3
-
2
-
-
54249124166
-
Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
-
Dilger, R. N. & Johnson, R. W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukoc. Biol. 84, 932-939 (2008).
-
(2008)
J. Leukoc. Biol.
, vol.84
, pp. 932-939
-
-
Dilger, R.N.1
Johnson, R.W.2
-
3
-
-
33846980461
-
Microglia derived from aging mice exhibit an altered inflammatory profile
-
Sierra, A., Gottfried-Blackmore, A. C., McEwen, B. S. & Bulloch, K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55, 412-424 (2007).
-
(2007)
Glia
, vol.55
, pp. 412-424
-
-
Sierra, A.1
Gottfried-Blackmore, A.C.2
McEwen, B.S.3
Bulloch, K.4
-
4
-
-
84892514122
-
Homeostatic and injury-induced microglia behavior in the aging brain
-
Hefendehl, J. K. et al. Homeostatic and injury-induced microglia behavior in the aging brain. Aging Cell 13, 60-69 (2014).
-
(2014)
Aging Cell
, vol.13
, pp. 60-69
-
-
Hefendehl, J.K.1
-
5
-
-
84897954445
-
Microglial dysfunction in brain aging and Alzheimers disease
-
Mosher, K. I. & Wyss-Coray, T. Microglial dysfunction in brain aging and Alzheimers disease. Biochem. Pharmacol. 88, 594-604 (2014).
-
(2014)
Biochem. Pharmacol.
, vol.88
, pp. 594-604
-
-
Mosher, K.I.1
Wyss-Coray, T.2
-
6
-
-
84861987890
-
Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences
-
Hart, A. D., Wyttenbach, A., Perry, V. H. & Teeling, J. L. Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences. Brain Behav. Immun. 26, 754-765 (2012).
-
(2012)
Brain Behav. Immun.
, vol.26
, pp. 754-765
-
-
Hart, A.D.1
Wyttenbach, A.2
Perry, V.H.3
Teeling, J.L.4
-
7
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
Villeda, S. A. et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90-94 (2011).
-
(2011)
Nature
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
-
8
-
-
84858702953
-
The ageing cortical synapse: Hallmarks and implications for cognitive decline
-
Morrison, J. H. & Baxter, M. G. The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat. Rev. Neurosci. 13, 240-250 (2012).
-
(2012)
Nat. Rev. Neurosci.
, vol.13
, pp. 240-250
-
-
Morrison, J.H.1
Baxter, M.G.2
-
9
-
-
0027390458
-
Quantitative synaptic alterations in the human neocortex during normal aging
-
Masliah, E., Mallory, M., Hansen, L., DeTeresa, R. & Terry, R. D. Quantitative synaptic alterations in the human neocortex during normal aging. Neurology 43, 192-197 (1993).
-
(1993)
Neurology
, vol.43
, pp. 192-197
-
-
Masliah, E.1
Mallory, M.2
Hansen, L.3
DeTeresa, R.4
Terry, R.D.5
-
10
-
-
9444289385
-
17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats
-
Bake, S. & Sohrabji, F. 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats. Endocrinology 145, 5471-5475 (2004).
-
(2004)
Endocrinology
, vol.145
, pp. 5471-5475
-
-
Bake, S.1
Sohrabji, F.2
-
11
-
-
84907783871
-
Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review
-
Heye, A. K., Culling, R. D., Valdes Hernandez, M. D., Thrippleton, M. J. & Wardlaw, J. M. Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review. Neuroimage Clin. 6, 262-274 (2014).
-
(2014)
Neuroimage Clin.
, vol.6
, pp. 262-274
-
-
Heye, A.K.1
Culling, R.D.2
Valdes Hernandez, M.D.3
Thrippleton, M.J.4
Wardlaw, J.M.5
-
12
-
-
0029863342
-
Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
-
Kuhn, H. G., Dickinson-Anson, H. & Gage, F. H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027-2033 (1996).
-
(1996)
J. Neurosci.
, vol.16
, pp. 2027-2033
-
-
Kuhn, H.G.1
Dickinson-Anson, H.2
Gage, F.H.3
-
13
-
-
84878831768
-
Dynamics of hippocampal neurogenesis in adult humans
-
Spalding, K. L. et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 153, 1219-1227 (2013).
-
(2013)
Cell
, vol.153
, pp. 1219-1227
-
-
Spalding, K.L.1
-
14
-
-
84902075251
-
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
-
Villeda, S. A. et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 20, 659-663 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 659-663
-
-
Villeda, S.A.1
-
15
-
-
50349094226
-
Expanding roles for leukotrienes in airway inflammation
-
Peters-Golden, M. Expanding roles for leukotrienes in airway inflammation. Curr. Allergy Asthma Rep. 8, 367-373 (2008).
-
(2008)
Curr. Allergy Asthma Rep.
, vol.8
, pp. 367-373
-
-
Peters-Golden, M.1
-
16
-
-
0029970797
-
Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma
-
Reiss, T. F. et al. Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma. J. Allergy Clin. Immunol. 98, 528-534 (1996).
-
(1996)
J. Allergy Clin. Immunol.
, vol.98
, pp. 528-534
-
-
Reiss, T.F.1
-
17
-
-
84870677586
-
Acute inflammation initiates the regenerative response in the adult zebrafish brain
-
Kyritsis, N. et al. Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science 338, 1353-1356 (2012).
-
(2012)
Science
, vol.338
, pp. 1353-1356
-
-
Kyritsis, N.1
-
18
-
-
33747885659
-
Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
-
Phillis, J. W., Horrocks, L. A. & Farooqui, A. A. Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. Brain Res. Rev. 52, 201-243 (2006).
-
(2006)
Brain Res. Rev.
, vol.52
, pp. 201-243
-
-
Phillis, J.W.1
Horrocks, L.A.2
Farooqui, A.A.3
-
19
-
-
75449085760
-
Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury
-
Farias, S., Frey, L. C., Murphy, R. C. & Heidenreich, K. A. Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. J Neurotrauma 26, 1977-1986 (2009).
-
(2009)
J Neurotrauma
, vol.26
, pp. 1977-1986
-
-
Farias, S.1
Frey, L.C.2
Murphy, R.C.3
Heidenreich, K.A.4
-
20
-
-
84870924565
-
Leukotriene D4 induces cognitive impairment through enhancement of CysLT(1) R-mediated amyloid-beta generation in mice
-
Tang, S. S. et al. Leukotriene D4 induces cognitive impairment through enhancement of CysLT(1) R-mediated amyloid-beta generation in mice. Neuropharmacology 65, 182-192 (2013).
-
(2013)
Neuropharmacology
, vol.65
, pp. 182-192
-
-
Tang, S.S.1
-
21
-
-
34447565153
-
The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
-
Chinnici, C. M., Yao, Y. & Pratico, D. The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol. Aging 28, 1457-1462 (2007).
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1457-1462
-
-
Chinnici, C.M.1
Yao, Y.2
Pratico, D.3
-
22
-
-
56349145808
-
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair
-
Lecca, D. et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS ONE 3, e3579 (2008).
-
(2008)
PLoS ONE
, vol.3
, pp. e3579
-
-
Lecca, D.1
-
23
-
-
84880407494
-
HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation
-
Zhang, X. Y. et al. HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation. J. Pharmacol. Exp. Ther. 346, 328-341 (2013).
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.346
, pp. 328-341
-
-
Zhang, X.Y.1
-
24
-
-
84922105542
-
Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats
-
Saad, M. A., Abdelsalam, R. M., Kenawy, S. A. & Attia, A. S. Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats. Neurochem. Res. 40, 139-150 (2015).
-
(2015)
Neurochem. Res.
, vol.40
, pp. 139-150
-
-
Saad, M.A.1
Abdelsalam, R.M.2
Kenawy, S.A.3
Attia, A.S.4
-
25
-
-
84907044040
-
Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction
-
Lenz, Q. F. et al. Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277, 859-871 (2014).
-
(2014)
Neuroscience
, vol.277
, pp. 859-871
-
-
Lenz, Q.F.1
-
26
-
-
83755207526
-
Inhibition of leukotriene receptors boosts neural progenitor proliferation
-
Huber, C. et al. Inhibition of leukotriene receptors boosts neural progenitor proliferation. Cell Physiol. Biochem. 28, 793-804 (2011).
-
(2011)
Cell Physiol. Biochem.
, vol.28
, pp. 793-804
-
-
Huber, C.1
-
27
-
-
84857121194
-
-
FDA. Montelukast. Singulair, application number
-
FDA, Montelukast. (Singulair, application number 20-829) (Pharmacology Review).
-
Pharmacology Review
, pp. 20-829
-
-
-
28
-
-
84857593754
-
An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo
-
Kozlowski, C. & Weimer, R. M. An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo. PLoS ONE 7, e31814 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e31814
-
-
Kozlowski, C.1
Weimer, R.M.2
-
29
-
-
0033559375
-
Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein
-
da Silva, R. P. & Gordon, S. Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein. Biochem J 338, 687-694 (1999).
-
(1999)
Biochem J
, vol.338
, pp. 687-694
-
-
Da Silva, R.P.1
Gordon, S.2
-
30
-
-
71549122565
-
Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins
-
Bake, S., Friedman, J. A. & Sohrabji, F. Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins. Microvasc. Res. 78, 413-424 (2009).
-
(2009)
Microvasc. Res.
, vol.78
, pp. 413-424
-
-
Bake, S.1
Friedman, J.A.2
Sohrabji, F.3
-
31
-
-
84876000187
-
Altered network timing in the CA3-CA1 circuit of hippocampal slices from aged mice
-
Kanak, D. J., Rose, G. M., Zaveri, H. P. & Patrylo, P. R. Altered network timing in the CA3-CA1 circuit of hippocampal slices from aged mice. PLoS ONE 8, e61364 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e61364
-
-
Kanak, D.J.1
Rose, G.M.2
Zaveri, H.P.3
Patrylo, P.R.4
-
32
-
-
34247566508
-
Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state
-
Maisel, M. et al. Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state. Stem Cells 25, 1231-1240 (2007).
-
(2007)
Stem Cells
, vol.25
, pp. 1231-1240
-
-
Maisel, M.1
-
33
-
-
84861976352
-
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
-
Ren, H. et al. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell 149, 1314-1326 (2012).
-
(2012)
Cell
, vol.149
, pp. 1314-1326
-
-
Ren, H.1
-
34
-
-
84930820415
-
Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: Implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS
-
Gao, B., Vavricka, S. R., Meier, P. J. & Stieger, B. Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS. Pflugers Arch. 467, 1481-1493 (2014).
-
(2014)
Pflugers Arch.
, vol.467
, pp. 1481-1493
-
-
Gao, B.1
Vavricka, S.R.2
Meier, P.J.3
Stieger, B.4
-
35
-
-
84907485873
-
Cellular specificity of the blood-CSF barrier for albumin transfer across the choroid plexus epithelium
-
Liddelow, S. A. et al. Cellular specificity of the blood-CSF barrier for albumin transfer across the choroid plexus epithelium. PLoS ONE 9, e106592 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e106592
-
-
Liddelow, S.A.1
-
36
-
-
84865312856
-
Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats. Pharmacol
-
Kumar, A., Prakash, A., Pahwa, D. & Mishra, J. Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats. Pharmacol. Biochem. Behav. 103, 43-52 (2012).
-
(2012)
Biochem. Behav.
, vol.103
, pp. 43-52
-
-
Kumar, A.1
Prakash, A.2
Pahwa, D.3
Mishra, J.4
-
37
-
-
77957878655
-
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: Possible behavioral, biochemical, mitochondrial and tumor necrosis factor-alpha level alterations in rats
-
Kalonia, H., Kumar, P., Kumar, A. & Nehru, B. Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-alpha level alterations in rats. Neuroscience 171, 284-299 (2010).
-
(2010)
Neuroscience
, vol.171
, pp. 284-299
-
-
Kalonia, H.1
Kumar, P.2
Kumar, A.3
Nehru, B.4
-
38
-
-
84902531840
-
Montelukast rescues primary neurons against Abeta1-42-induced toxicity through inhibiting CysLT1R-mediated NF-kappaB signaling
-
Lai, J. et al. Montelukast rescues primary neurons against Abeta1-42-induced toxicity through inhibiting CysLT1R-mediated NF-kappaB signaling. Neurochem. Int. 75, 26-31 (2014).
-
(2014)
Neurochem. Int.
, vol.75
, pp. 26-31
-
-
Lai, J.1
-
39
-
-
10844232942
-
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, doseand time-dependently protects against focal cerebral ischemia in mice
-
Yu, G. L. et al. Montelukast, a cysteinyl leukotriene receptor-1 antagonist, doseand time-dependently protects against focal cerebral ischemia in mice. Pharmacology 73, 31-40 (2005).
-
(2005)
Pharmacology
, vol.73
, pp. 31-40
-
-
Yu, G.L.1
-
40
-
-
84926132472
-
Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats
-
Cavus, G. et al. Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats. Eur. Rev. Med. Pharmacol. Sci. 18, 1770-1777 (2014).
-
(2014)
Eur. Rev. Med. Pharmacol. Sci.
, vol.18
, pp. 1770-1777
-
-
Cavus, G.1
-
41
-
-
84903690786
-
Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1
-
Zhang, X. Y. et al. Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1. Brain Res. 1572, 59-71 (2014).
-
(2014)
Brain Res.
, vol.1572
, pp. 59-71
-
-
Zhang, X.Y.1
-
42
-
-
84860775990
-
Cognitive and behavioral consequences of impaired immunoregulation in aging
-
Corona, A. W., Fenn, A. M. & Godbout, J. P. Cognitive and behavioral consequences of impaired immunoregulation in aging. J. Neuroimmune Pharmacol. 7, 7-23 (2012).
-
(2012)
J. Neuroimmune Pharmacol.
, vol.7
, pp. 7-23
-
-
Corona, A.W.1
Fenn, A.M.2
Godbout, J.P.3
-
43
-
-
84930928563
-
Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?
-
Zheng, X. et al. Thinking outside the brain for cognitive improvement: is peripheral immunomodulation on the way? Neuropharmacology 96, 94-104 (2014).
-
(2014)
Neuropharmacology
, vol.96
, pp. 94-104
-
-
Zheng, X.1
-
44
-
-
80052672267
-
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis
-
Wang, L. et al. Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 187, 2336-2345 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 2336-2345
-
-
Wang, L.1
-
45
-
-
48849109215
-
Physical activity and the regulation of neurogenesis in the adult and aging brain
-
Fabel, K. & Kempermann, G. Physical activity and the regulation of neurogenesis in the adult and aging brain. Neuromol. Med. 10, 59-66 (2008).
-
(2008)
Neuromol. Med.
, vol.10
, pp. 59-66
-
-
Fabel, K.1
Kempermann, G.2
-
46
-
-
0344198502
-
Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis
-
Drapeau, E. et al. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc. Natl Acad. Sci. USA 100, 14385-14390 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 14385-14390
-
-
Drapeau, E.1
-
47
-
-
84907659600
-
Aging. Aging-induced type i interferon response at the choroid plexus negatively affects brain function
-
Baruch, K. et al. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science 346, 89-93 (2014).
-
(2014)
Science
, vol.346
, pp. 89-93
-
-
Baruch, K.1
-
48
-
-
84868207687
-
Neural progenitor cells regulate microglia functions and activity
-
Mosher, K. I. et al. Neural progenitor cells regulate microglia functions and activity. Nat. Neurosci. 15, 1485-1487 (2012).
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1485-1487
-
-
Mosher, K.I.1
-
49
-
-
77957328867
-
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
-
Sierra, A. et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 7, 483-495 (2010).
-
(2010)
Cell Stem Cell
, vol.7
, pp. 483-495
-
-
Sierra, A.1
-
50
-
-
84872659111
-
Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice
-
Kohman, R. A., Bhattacharya, T. K., Kilby, C., Bucko, P. & Rhodes, J. S. Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice. Behav. Brain Res. 242, 17-24 (2013).
-
(2013)
Behav. Brain Res.
, vol.242
, pp. 17-24
-
-
Kohman, R.A.1
Bhattacharya, T.K.2
Kilby, C.3
Bucko, P.4
Rhodes, J.S.5
-
51
-
-
70350497348
-
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
-
Paik, J. H. et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5, 540-553 (2009).
-
(2009)
Cell Stem Cell
, vol.5
, pp. 540-553
-
-
Paik, J.H.1
-
52
-
-
67749129263
-
The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury
-
Ceruti, S. et al. The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. Brain 132, 2206-2218 (2009).
-
(2009)
Brain
, vol.132
, pp. 2206-2218
-
-
Ceruti, S.1
-
53
-
-
42049114647
-
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimers disease
-
Firuzi, O., Zhuo, J., Chinnici, C. M., Wisniewski, T. & Pratico, D. 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimers disease. FASEB J. 22, 1169-1178 (2008).
-
(2008)
FASEB J.
, vol.22
, pp. 1169-1178
-
-
Firuzi, O.1
Zhuo, J.2
Chinnici, C.M.3
Wisniewski, T.4
Pratico, D.5
-
54
-
-
56449106689
-
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimers disease
-
Ikonomovic, M. D., Abrahamson, E. E., Uz, T., Manev, H. & Dekosky, S. T. Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimers disease. J. Histochem. Cytochem. 56, 1065-1073 (2008).
-
(2008)
J. Histochem. Cytochem.
, vol.56
, pp. 1065-1073
-
-
Ikonomovic, M.D.1
Abrahamson, E.E.2
Uz, T.3
Manev, H.4
Dekosky, S.T.5
-
55
-
-
2642693710
-
Aging-associated up-regulation of neuronal 5-lipoxygenase expression: Putative role in neuronal vulnerability
-
Uz, T., Pesold, C., Longone, P. & Manev, H. Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability. FASEB J. 12, 439-449 (1998).
-
(1998)
FASEB J.
, vol.12
, pp. 439-449
-
-
Uz, T.1
Pesold, C.2
Longone, P.3
Manev, H.4
-
56
-
-
84884823319
-
Leukotriene receptor antagonists, LY293111 and ONO-1078, protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors
-
Yagami, T., Yamamoto, Y. & Kohma, H. Leukotriene receptor antagonists, LY293111 and ONO-1078, protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors. Neurochem. Int. 63, 163-171 (2013).
-
(2013)
Neurochem. Int.
, vol.63
, pp. 163-171
-
-
Yagami, T.1
Yamamoto, Y.2
Kohma, H.3
-
57
-
-
84879601098
-
UDP-glucose enhances outward K() currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors
-
Coppi, E. et al. UDP-glucose enhances outward K() currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors. Glia 61, 1155-1171 (2013).
-
(2013)
Glia
, vol.61
, pp. 1155-1171
-
-
Coppi, E.1
-
58
-
-
84907620551
-
Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation
-
Sensi, C. et al. Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation. Cell Signal 26, 2614-2620 (2014).
-
(2014)
Cell Signal
, vol.26
, pp. 2614-2620
-
-
Sensi, C.1
-
59
-
-
84884634477
-
Is GPR17 a P2Y/leukotriene receptor? Examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17
-
Qi, A. D., Harden, T. K. & Nicholas, R. A. Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. J. Pharmacol. Exp. Ther. 347, 38-46 (2013).
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.347
, pp. 38-46
-
-
Qi, A.D.1
Harden, T.K.2
Nicholas, R.A.3
-
60
-
-
84886745200
-
Decoding signaling and function of the orphan G proteincoupled receptor GPR17 with a small-molecule agonist
-
Hennen, S. et al. Decoding signaling and function of the orphan G proteincoupled receptor GPR17 with a small-molecule agonist. Sci. Signal 6, ra93 (2013).
-
(2013)
Sci. Signal
, vol.6
, pp. 93
-
-
Hennen, S.1
-
61
-
-
84863695210
-
Prediction of drug-target interactions and drug repositioning via network-based inference
-
Cheng, F. et al. Prediction of drug-target interactions and drug repositioning via network-based inference. PLoS Comput. Biol. 8, e1002503 (2012).
-
(2012)
PLoS Comput. Biol.
, vol.8
, pp. e1002503
-
-
Cheng, F.1
-
62
-
-
84884829726
-
Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimers disease
-
Kosaraju, J. et al. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimers disease. Neuropharmacology 72, 291-300 (2013).
-
(2013)
Neuropharmacology
, vol.72
, pp. 291-300
-
-
Kosaraju, J.1
-
63
-
-
0035253496
-
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo
-
Steinbrecher, A. et al. Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. J. Immunol. 166, 2041-2048 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 2041-2048
-
-
Steinbrecher, A.1
-
64
-
-
84898893756
-
Rat choroidal pericytes as a target of the autonomic nervous system
-
Schrodl, F. et al. Rat choroidal pericytes as a target of the autonomic nervous system. Cell Tissue Res. 356, 1-8 (2014).
-
(2014)
Cell Tissue Res.
, vol.356
, pp. 1-8
-
-
Schrodl, F.1
-
65
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik, J. H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007).
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
-
66
-
-
74449091354
-
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination
-
Chen, Y. et al. The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat. Neurosci. 12, 1398-1406 (2009).
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 1398-1406
-
-
Chen, Y.1
-
67
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408 (2001).
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
68
-
-
0025233694
-
Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus
-
Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R. & Bistoni, F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus J. Neuroimmunol. 27, 229-237 (1990).
-
(1990)
J. Neuroimmunol.
, vol.27
, pp. 229-237
-
-
Blasi, E.1
Barluzzi, R.2
Bocchini, V.3
Mazzolla, R.4
Bistoni, F.5
-
69
-
-
77958045673
-
RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus
-
Ehm, O. et al. RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. J. Neurosci. 30, 13794-13807 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 13794-13807
-
-
Ehm, O.1
-
70
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae, J., Kitamura, T., Silver, D. L. & Accili, D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359-1367 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
|