Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation

Cellular Signalling

Volumn 26, Issue 12, 2014, Pages 2614-2620

  Sensi, Cristina ^a   Daniele, Simona ^b   Parravicini, Chiara ^a   Zappelli, Elisa ^b   Russo, Vincenzo ^c   Trincavelli, Maria L ^b   Martini, Claudia ^b   Abbracchio, Maria P ^a   Eberini, Ivano ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c Institute San Raffaele   (Italy)

Author keywords

Cell signaling; Cholesterol; G proteins; Molecular recognition; Oxysterols; Receptors seven transmembrane domain

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; EBI2 PROTEIN; G PROTEIN COUPLED RECEPTOR; GPR17 PROTEIN; LIGAND; OXYSTEROL; UNCLASSIFIED DRUG; GPR17 PROTEIN, HUMAN; GPR183 PROTEIN, HUMAN;

ARTICLE; BINDING KINETICS; BINDING SITE; CHEMICAL INTERACTION; COMPUTER MODEL; CONCENTRATION (PARAMETERS); IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR RECOGNITION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VALIDATION PROCESS; CHEMICAL STRUCTURE; COMPUTER SIMULATION; DEGENERATIVE DISEASE; HUMAN; INFLAMMATION; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY;

BINDING SITES; COMPUTER SIMULATION; HUMANS; IN VITRO TECHNIQUES; INFLAMMATION; LIGANDS; MODELS, MOLECULAR; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION;

EID: 84907620551     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.08.003     Document Type: Article

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