Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer

Oncotarget

Volumn 6, Issue 31, 2015, Pages 31119-31133

  Li, Wei ^a   Ma, Zhenhua ^a   Ma, Jiguang ^a   Li, Xuqi ^a   Xu, Qinhong ^a   Duan, Wanxing ^a   Chen, Xin ^a   Lv, Yunfu ^b   Zhou, Shuang ^c   Wu, Erxi ^c   Ma, Qingyong ^a   Huo, Xiongwei ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b HAINAN PROVINCIAL PEOPLE S HOSPITAL   (China)

^c NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Diabetes; Hydrogen peroxide; MAPK pathway; Pancreatic cancer invasion; SOD2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROGOL; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; STREPTOZOCIN; TRANSCRIPTION FACTOR AP 1; UROKINASE; MESSENGER RNA; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER TISSUE; CELL INVASION; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; KIDNEY CAPSULE; MALE; MOUSE; NONHUMAN; OPTICAL DENSITY; OXIDATIVE STRESS; PANCREAS CANCER; PANCREAS RESECTION; PROTEIN EXPRESSION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TIME; TUMOR INVASION; UPREGULATION; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; ENZYME IMMUNOASSAY; GENETICS; METABOLISM; PANCREATIC NEOPLASMS; PATHOLOGY; PATHOPHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; HYDROGEN PEROXIDE; HYPERGLYCEMIA; IMMUNOENZYME TECHNIQUES; MICE; MICE, INBRED BALB C; OXIDANTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84945531306     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5045     Document Type: Article

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