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Volumn 68, Issue 7, 2011, Pages 573-584

Management strategies in pancreatic cancer

Author keywords

Antineoplastic agents; Combined therapy; Dosage; Drug information; Gemcitabine; Pancreatic neoplasms; Pharmaceutical services; Pharmacists; Toxicity

Indexed keywords

ANTIBIOTIC AGENT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EXATECAN; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IPI 926; IRINOTECAN; MARIMASTAT; NANOPARTICLE FORMULATED ALBUMIN STABILIZED PACLITAXEL; OXALIPLATIN; PACLITAXEL DERIVATIVE; PEMETREXED; RADIOSENSITIZING AGENT; SMALL MOLECULE TRANSPORT AGENT; STEROID; TIPIFARNIB; UNCLASSIFIED DRUG; VISMODEGIB;

EID: 79956008277     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp100254     Document Type: Review
Times cited : (23)

References (77)
  • 2
    • 67650410937 scopus 로고    scopus 로고
    • Atlanta: American Cancer Society
    • Cancer facts & figures 2009. Atlanta: American Cancer Society; 2009.
    • (2009) Cancer Facts & Figures 2009
  • 3
    • 34047106787 scopus 로고    scopus 로고
    • Supportive and palliative care of pancreatic cancer
    • Fazal S, Saif MW. Supportive and palliative care of pancreatic cancer. JOP. 2007; 8:240-53. (Pubitemid 46522756)
    • (2007) Journal of the Pancreas , vol.8 , Issue.2 , pp. 240-253
    • Fazal, S.1    Saif, M.W.2
  • 4
    • 45749089796 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer 2008: Is the glass less empty?
    • Nieto J, Grossbard ML, Kozuch P. Metastatic pancreatic cancer 2008: is the glass less empty? Oncologist. 2008; 13:562-76.
    • (2008) Oncologist , vol.13 , pp. 562-576
    • Nieto, J.1    Grossbard, M.L.2    Kozuch, P.3
  • 5
    • 0033805718 scopus 로고    scopus 로고
    • Treatment of resectable and locally advanced pancreatic cancer
    • Kuvshinoff B, Bryer M. Treatment of resectable and locally advanced pancreatic cancer. Cancer Control. 2000; 7:428-36.
    • (2000) Cancer Control , vol.7 , pp. 428-436
    • Kuvshinoff, B.1    Bryer, M.2
  • 6
    • 0029002348 scopus 로고
    • Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients
    • Yeo CJ, Cameron JL, Lillemoe KD et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients. Ann Surg. 1995; 221:721-31.
    • (1995) Ann Surg , vol.221 , pp. 721-731
    • Yeo, C.J.1    Cameron, J.L.2    Lillemoe, K.D.3
  • 7
    • 0034329115 scopus 로고    scopus 로고
    • Resected adenocarcinoma of the pancreas - 616 patients: Results, outcomes, and prognostic indicators
    • Sohn TA, Yeo CJ, Cameron JL et al. Resected adenocarcinoma of the pancreas - 616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000; 4:567-79.
    • (2000) J Gastrointest Surg , vol.4 , pp. 567-579
    • Sohn, T.A.1    Yeo, C.J.2    Cameron, J.L.3
  • 8
    • 0021867923 scopus 로고
    • Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection
    • Kalser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 1985; 120:899-903. (Pubitemid 15040883)
    • (1985) Archives of Surgery , vol.120 , Issue.8 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 9
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group
    • Klinkenbijl JH, Jeekel J, Sahmoud T et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg. 1999; 230:776-82.
    • (1999) Ann Surg , vol.230 , pp. 776-782
    • Klinkenbijl, J.H.1    Jeekel, J.2    Sahmoud, T.3
  • 13
    • 70350171770 scopus 로고    scopus 로고
    • ESPAC-3(v2): A multicenter, international, open-label, randomized, controlled phase III trial of adjuvant 5-fluorouracil/folinic acid (5-FU/FA) versus gemcitabine (GEM) in patients with resected pancreatic ductal adenocarcinoma
    • Neoptolemos J, Buchler M, Stocken DD et al. ESPAC-3(v2): a multicenter, international, open-label, randomized, controlled phase III trial of adjuvant 5-fluorouracil/folinic acid (5-FU/FA) versus gemcitabine (GEM) in patients with resected pancreatic ductal adenocarcinoma. J Clin Oncol (Meeting Abstracts). 2009; 27(suppl 18):LBA4505.
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , Issue.SUPPL. 18
    • Neoptolemos, J.1    Buchler, M.2    Stocken, D.D.3
  • 14
    • 49749128110 scopus 로고    scopus 로고
    • Neoadjuvant therapy for pancreatic cancer
    • Lowy AM. Neoadjuvant therapy for pancreatic cancer. J Gastrointest Surg. 2008; 12:1600-8.
    • (2008) J Gastrointest Surg , vol.12 , pp. 1600-1608
    • Lowy, A.M.1
  • 15
    • 49049101358 scopus 로고    scopus 로고
    • Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head
    • Evans DB, Varadhachary GR, Crane CH et al. Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. J Clin Oncol. 2008; 26:3496-502.
    • (2008) J Clin Oncol , vol.26 , pp. 3496-3502
    • Evans, D.B.1    Varadhachary, G.R.2    Crane, C.H.3
  • 16
    • 49049102131 scopus 로고    scopus 로고
    • Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head
    • Varadhachary GR, Wolff RA, Crane CH et al. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol. 2008; 26:3487-95.
    • (2008) J Clin Oncol , vol.26 , pp. 3487-3495
    • Varadhachary, G.R.1    Wolff, R.A.2    Crane, C.H.3
  • 17
    • 43049106807 scopus 로고    scopus 로고
    • Borderline resectable pancreatic cancer: The importance of this emerging stage of disease
    • Katz MH, Pisters PW, Evans DB et al. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg. 2008; 206:833-46.
    • (2008) J Am Coll Surg , vol.206 , pp. 833-846
    • Katz, M.H.1    Pisters, P.W.2    Evans, D.B.3
  • 18
    • 48949101462 scopus 로고    scopus 로고
    • A randomized phase III study of gemcitabine in combination with radiation therapy versus gemcitabine alone in patients with localized, unresectable pancreatic cancer: E4201
    • Loehrer PJ Sr, Powell ME, Cardenes HR et al. A randomized phase III study of gemcitabine in combination with radiation therapy versus gemcitabine alone in patients with localized, unresectable pancreatic cancer: E4201. J Clin Oncol (Meeting Abstracts). 2008; 26(suppl 15):4506.
    • (2008) J Clin Oncol (Meeting Abstracts) , vol.26 , Issue.SUPPL. 15 , pp. 4506
    • Loehrer Sr., P.J.1    Powell, M.E.2    Cardenes, H.R.3
  • 19
    • 34247252488 scopus 로고    scopus 로고
    • Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy
    • DOI 10.1038/sj.bjc.6603719, PII 6603719
    • Sultana A, Tudur Smith C, Cunningham D et al. Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. Br J Cancer. 2007; 96:1183-90. (Pubitemid 46625082)
    • (2007) British Journal of Cancer , vol.96 , Issue.8 , pp. 1183-1190
    • Sultana, A.1    Tudur, S.C.2    Cunningham, D.3    Starling, N.4    Tait, D.5    Neoptolemos, J.P.6    Ghaneh, P.7
  • 21
    • 65549143674 scopus 로고    scopus 로고
    • Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: A qualitative systematic review
    • Huguet F, Girard N, Guerche CS et al. Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: a qualitative systematic review. J Clin Oncol. 2009; 27:2269-77.
    • (2009) J Clin Oncol , vol.27 , pp. 2269-2277
    • Huguet, F.1    Girard, N.2    Guerche, C.S.3
  • 23
    • 42349093032 scopus 로고    scopus 로고
    • Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
    • Heinemann V, Boeck S, Hinke A et al. Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer. 2008; 8:82.
    • (2008) BMC Cancer , vol.8 , pp. 82
    • Heinemann, V.1    Boeck, S.2    Hinke, A.3
  • 24
    • 0025978216 scopus 로고
    • A phase I clinical, plasma, and cellular pharmacology study of gemcitabine
    • Abbruzzese JL, Grunewald R, Weeks EA et al. A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol. 1991; 9:491-8.
    • (1991) J Clin Oncol , vol.9 , pp. 491-498
    • Abbruzzese, J.L.1    Grunewald, R.2    Weeks, E.A.3
  • 25
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S, Ogata S, Tsuda H et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas. 2004; 29:e1-8.
    • (2004) Pancreas , vol.29
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3
  • 27
    • 36348999029 scopus 로고    scopus 로고
    • Is it cost-effective to add erlotinib to gemcitabine in advanced pancreatic cancer?
    • Grubbs SS, Grusenmeyer PA, Petrelli NJ et al. Is it cost-effective to add erlotinib to gemcitabine in advanced pancreatic cancer? J Clin Oncol (Meeting Abstracts). 2006; 24(suppl 18):6048.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , Issue.SUPPL. 18 , pp. 6048
    • Grubbs, S.S.1    Grusenmeyer, P.A.2    Petrelli, N.J.3
  • 28
    • 77954507007 scopus 로고    scopus 로고
    • Cost effectiveness of cytotoxic and targeted therapy for metastatic breast cancer: A critical and systematic review
    • Blank P, Dedes K, Szucs T. Cost effectiveness of cytotoxic and targeted therapy for metastatic breast cancer: a critical and systematic review. Pharmacoeconomics. 2010; 28:629-47.
    • (2010) Pharmacoeconomics , vol.28 , pp. 629-647
    • Blank, P.1    Dedes, K.2    Szucs, T.3
  • 29
    • 0026550270 scopus 로고
    • Gemcitabine in leukemia: A phase I clinical, plasma, and cellular pharmacology study
    • Grunewald R, Kantarjian H, Du M et al. Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study. J Clin Oncol. 1992; 10:406-13.
    • (1992) J Clin Oncol , vol.10 , pp. 406-413
    • Grunewald, R.1    Kantarjian, H.2    Du, M.3
  • 30
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixeddose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
    • Poplin E, Feng Y, Berlin J et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixeddose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol. 2009; 27:3778-85.
    • (2009) J Clin Oncol , vol.27 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3
  • 31
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
    • Louvet C, Labianca R, Hammel P et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol. 2005; 23:3509-16.
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 32
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: A prospective, randomized phase III study of the Gruppo Oncologico dell'Italia Meridionale
    • DOI 10.1002/cncr.10323
    • Colucci G, Giuliani F, Gebbia V et al. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer. 2002; 94:902-10. (Pubitemid 34150843)
    • (2002) Cancer , vol.94 , Issue.4 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3    Biglietto, M.4    Rabitti, P.5    Uomo, G.6    Cigolari, S.7    Testa, A.8    Maiello, E.9    Lopez, M.10
  • 34
    • 77950498286 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: The GIP-1 study
    • Colucci G, Labianca R, Di Costanzo F et al. Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J Clin Oncol. 2010; 28:1645-51.
    • (2010) J Clin Oncol , vol.28 , pp. 1645-1651
    • Colucci, G.1    Labianca, R.2    Di Costanzo, F.3
  • 36
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken DD et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2009; 27:5513-8.
    • (2009) J Clin Oncol , vol.27 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3
  • 37
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group trial E2297
    • DOI 10.1200/JCO.2002.11.149
    • Berlin JD, Catalano P, Thomas JP et al. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol. 2002; 20:3270-5. (Pubitemid 34831525)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.15 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 38
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer. 2002; 87:161-7.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 39
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • DOI 10.1200/JCO.2004.12.082
    • Rocha Lima CM, Green MR, Rotche R et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol. 2004; 22:3776-83. (Pubitemid 41095218)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.18 , pp. 3776-3783
    • Lima, C.M.R.1    Green, M.R.2    Rotche, R.3    Miller Jr., W.H.4    Jeffrey, G.M.5    Cisar, L.A.6    Morganti, A.7    Orlando, N.8    Gruia, G.9    Miller, L.L.10
  • 44
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol. 2009; 27:2231-7.
    • (2009) J Clin Oncol , vol.27 , pp. 2231-2237
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 45
    • 36549083856 scopus 로고    scopus 로고
    • Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study
    • Philip PA, Benedetti J, Fenoglio-Preiser C et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. J Clin Oncol (Meeting Abstracts). 2007; 25(suppl 18):LBA4509.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.SUPPL. 18
    • Philip, P.A.1    Benedetti, J.2    Fenoglio-Preiser, C.3
  • 46
    • 35548941394 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of cancer and leukemia group B (CALGB)
    • Kindler HL, Niedzwiecki D, Hollis D et al. A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of cancer and leukemia group B (CALGB). J Clin Oncol (Meeting Abstracts). 2007; 25(suppl 18):4508.
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , Issue.SUPPL. 18 , pp. 4508
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3
  • 47
    • 42349083012 scopus 로고    scopus 로고
    • Capecitabine: An overview of the side effects and their management
    • DOI 10.1097/CAD.0b013e3282f945aa, PII 0000181320080600000002
    • Saif MW, Katirtzoglou NA, Syrigos KN. Capecitabine: an overview of the side effects and their management. Anticancer Drugs. 2008; 19:447-64. (Pubitemid 351556397)
    • (2008) Anti-Cancer Drugs , vol.19 , Issue.5 , pp. 447-464
    • Saif, M.W.1    Katirtzoglou, N.A.2    Syrigos, K.N.3
  • 48
    • 29344476191 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer
    • Abstract
    • Cunningham D, Chau I, Stocken C et al. Phase III randomized comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer. Eur J Cancer. 2005; 12(suppl 3):PS11. Abstract.
    • (2005) Eur J Cancer , vol.12 , Issue.SUPPL. 3
    • Cunningham, D.1    Chau, I.2    Stocken, C.3
  • 49
    • 77954771890 scopus 로고    scopus 로고
    • Randomized phase III trial comparing FOLFIRINOX (F: 5FU/leucovorin [LV], irinotecan [I], and oxaliplatin [O]) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): preplanned interim analysis results of the PRODIGE 4/ACCORD 11 trial
    • Conroy T, Desseigne F, Ychou M et al. Randomized phase III trial comparing FOLFIRINOX (F: 5FU/leucovorin [LV], irinotecan [I], and oxaliplatin [O]) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): preplanned interim analysis results of the PRODIGE 4/ACCORD 11 trial. J Clin Oncol (Meeting Abstracts). 2010; 28:4010.
    • (2010) J Clin Oncol (Meeting Abstracts) , vol.28 , pp. 4010
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 50
    • 33344475959 scopus 로고    scopus 로고
    • Oxaliplatin/folinic acid/5-fluorouracil [24h] (OFF) plus best supportive care versus best supportive care alone (BSC) in second-line therapy of gemcitabine-refractory advanced pancreatic cancer (CONKO 003)
    • Oettle H, Pelzer U, Stieler J et al. Oxaliplatin/folinic acid/5-fluorouracil [24h] (OFF) plus best supportive care versus best supportive care alone (BSC) in second-line therapy of gemcitabine-refractory advanced pancreatic cancer (CONKO 003). J Clin Oncol (Meeting Abstracts). 2005; 23:4031.
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , pp. 4031
    • Oettle, H.1    Pelzer, U.2    Stieler, J.3
  • 51
    • 48949087810 scopus 로고    scopus 로고
    • A randomized trial in patients with gemcitabine refractory pancreatic cancer. Final results of the CONKO 003 study
    • Pelzer U, Kubica K, Stieler J et al. A randomized trial in patients with gemcitabine refractory pancreatic cancer. Final results of the CONKO 003 study. J Clin Oncol (Meeting Abstracts). 2008; 26:4508.
    • (2008) J Clin Oncol (Meeting Abstracts) , vol.26 , pp. 4508
    • Pelzer, U.1    Kubica, K.2    Stieler, J.3
  • 53
    • 37849012740 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals
    • Ling J, Fettner S, Lum BL et al. Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals. Anticancer Drugs. 2008; 19:209-16.
    • (2008) Anticancer Drugs , vol.19 , pp. 209-216
    • Ling, J.1    Fettner, S.2    Lum, B.L.3
  • 54
    • 38049054403 scopus 로고    scopus 로고
    • The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: Computer-based simulation (SimCYP) predicts in vivo metabolic inhibition
    • Rakhit A, Pantze MP, Fettner S et al. The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition. Eur J Clin Pharmacol. 2008; 64:31-41.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 31-41
    • Rakhit, A.1    Pantze, M.P.2    Fettner, S.3
  • 55
    • 33646238486 scopus 로고    scopus 로고
    • Effects of smoking on the pharmacokinetics of erlotinib
    • Hamilton M, Wolf JL, Rusk J et al. Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006; 12(7 pt 1):2166-71.
    • (2006) Clin Cancer Res , vol.12 , Issue.7 PART 1 , pp. 2166-2171
    • Hamilton, M.1    Wolf, J.L.2    Rusk, J.3
  • 56
    • 62449241907 scopus 로고    scopus 로고
    • Overcoming CYP1A1/1A2 mediated induction of metabolism by escalating erlotinib dose in current smokers
    • Hughes AN, O'Brien ME, Petty WJ et al. Overcoming CYP1A1/1A2 mediated induction of metabolism by escalating erlotinib dose in current smokers. J Clin Oncol. 2009; 27:1220-6.
    • (2009) J Clin Oncol , vol.27 , pp. 1220-1226
    • Hughes, A.N.1    O'Brien, M.E.2    Petty, W.J.3
  • 57
    • 35548969264 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: An evolving paradigm in clinical management
    • DOI 10.1634/theoncologist.12-5-610
    • Lynch TJ Jr, Kim ES, Eaby B et al. Epidermal growth factor receptor inhibitorassociated cutaneous toxicities: an evolving paradigm in clinical management. Oncologist. 2007; 12:610-21. (Pubitemid 350012125)
    • (2007) Oncologist , vol.12 , Issue.5 , pp. 610-621
    • Lynch Jr., T.J.1    Kim, E.S.2    Eaby, B.3    Garey, J.4    West, D.P.5    Lacouture, M.E.6
  • 58
    • 45549084968 scopus 로고    scopus 로고
    • An interdisciplinary consensus on managing skin reactions associated with human epidermal growth factor receptor inhibitors
    • Eaby B, Culkin A, Lacouture ME. An interdisciplinary consensus on managing skin reactions associated with human epidermal growth factor receptor inhibitors. Clin J Oncol Nurs. 2008; 12:283-90.
    • (2008) Clin J Oncol Nurs , vol.12 , pp. 283-290
    • Eaby, B.1    Culkin, A.2    Lacouture, M.E.3
  • 59
    • 34447129570 scopus 로고    scopus 로고
    • Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies
    • DOI 10.1158/1078-0432.CCR-06-2610
    • Wacker B, Nagrani T, Weinberg J et al. Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res. 2007; 13:3913-21. (Pubitemid 47037599)
    • (2007) Clinical Cancer Research , vol.13 , Issue.13 , pp. 3913-3921
    • Wacker, B.1    Nagrani, T.2    Weinberg, J.3    Witt, K.4    Clark, G.5    Cagnoni, P.J.6
  • 61
    • 73949107880 scopus 로고    scopus 로고
    • Consensus report of the National Cancer Institute clinical trials planning meeting on pancreas cancer treatment
    • Philip PA, Mooney M, Jaffe D et al. Consensus report of the National Cancer Institute clinical trials planning meeting on pancreas cancer treatment. J Clin Oncol. 2009; 27:5660-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5660-5669
    • Philip, P.A.1    Mooney, M.2    Jaffe, D.3
  • 62
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    • DOI 10.1158/1535-7163.MCT-06-0686
    • Mahadevan D, Von Hoff D. Tumorstroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2007; 6:1186-97. (Pubitemid 46711982)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.4 , pp. 1186-1197
    • Mahadevan, D.1    Von Hoff, D.D.2
  • 63
    • 77950554464 scopus 로고    scopus 로고
    • Stromal depletion goes on trial in pancreatic cancer
    • Garber K. Stromal depletion goes on trial in pancreatic cancer. J Natl Cancer Inst. 2010; 102:448-50.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 448-450
    • Garber, K.1
  • 64
    • 68049128117 scopus 로고    scopus 로고
    • Paracrine hedgehog signaling in cancer
    • Theunissen J, de Sauvage F. Paracrine hedgehog signaling in cancer. Cancer Res. 2009; 69:6007-10.
    • (2009) Cancer Res , vol.69 , pp. 6007-6010
    • Theunissen, J.1    De Sauvage, F.2
  • 66
    • 77949719411 scopus 로고    scopus 로고
    • Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts
    • Walter K, Omura N, Hong SM et al. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin Cancer Res. 2010; 16:1781-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 1781-1789
    • Walter, K.1    Omura, N.2    Hong, S.M.3
  • 67
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009; 324:1457-61.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 71
    • 68649119049 scopus 로고    scopus 로고
    • SPARC correlation with response to gemcitabine (G) plus nab-paclitaxel (nab-P) in patients with advanced metastatic pancreatic cancer: A phase I/ II study
    • Von Hoff DD, Ramanathan R, Borad M et al. SPARC correlation with response to gemcitabine (G) plus nab-paclitaxel (nab-P) in patients with advanced metastatic pancreatic cancer: a phase I/ II study. J Clin Oncol (Meeting Abstracts). 2009; 27(suppl 15):4525.
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , Issue.SUPPL. 15 , pp. 4525
    • Von Hoff, D.D.1    Ramanathan, R.2    Borad, M.3
  • 75
    • 0042284883 scopus 로고    scopus 로고
    • SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions
    • DOI 10.1038/sj.onc.1206807
    • Sato N, Fukushima N, Maehara N et al. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene. 2003; 22:5021-30. (Pubitemid 37026400)
    • (2003) Oncogene , vol.22 , Issue.32 , pp. 5021-5030
    • Sato, N.1    Fukushima, N.2    Maehara, N.3    Matsubayashi, H.4    Koopmann, J.5    Su, G.H.6    Hruban, R.H.7    Goggins, M.8
  • 76
    • 77951931628 scopus 로고    scopus 로고
    • Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer
    • Gao J, Song J, Huang H et al. Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer. J Exp Clin Cancer Res. 2010; 29:28.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 28
    • Gao, J.1    Song, J.2    Huang, H.3
  • 77
    • 52649119391 scopus 로고    scopus 로고
    • Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status
    • Desai NP, Trieu V, Hwang LY et al. Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status. Anticancer Drugs. 2008; 19:899-909.
    • (2008) Anticancer Drugs , vol.19 , pp. 899-909
    • Desai, N.P.1    Trieu, V.2    Hwang, L.Y.3


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