Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients

Diabetes and Metabolism

Volumn 34, Issue 2, 2008, Pages 117-124

  Garcia Ramirez M ^a   Francisco, G ^a   Garcia Arumi E ^b   Hernandez C ^a   Martinez R ^b   Andreu, A L ^b   Simo R ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Diabetic complications; Manganese superoxide dismutase; Mitochondria; Mitochondrial DNA; Oxidative stress; Type 2 diabetes

Indexed keywords

CYTOCHROME C OXIDASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; RESPIRATORY CHAIN; STATISTICAL SIGNIFICANCE;

AGED; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; DNA, MITOCHONDRIAL; DRUG THERAPY, COMBINATION; FEMALE; GENE AMPLIFICATION; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OXIDATIVE STRESS; REFERENCE VALUES; SUPEROXIDE DISMUTASE;

EID: 42249085763     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabet.2007.10.011     Document Type: Article

References (46)

1. Ceriello A. New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care 26 (2003) 1589-1596
2. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
3. Ceriello A., Bortolotti N., Crescentini A., Motz E., Lizzio S., Russo A., et al. Antioxidant defences are reduced during the oral glucose tolerance test in normal and non-insulin-dependent diabetic subjects. Eur J Clin Invest 28 (1998) 329-333
4. Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 (2000) 787-790
5. Kiritoshi S., Nishikawa T., Sonoda K., Kukidome D., Senokuchi T., Matsuo T., et al. Reactive oxygen species from mitochondria induce cyclo-oxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes 52 (2003) 2570-2577
6. Piconi L., Quagliaro L., Assaloni R., Da Ros R., Maier A., Zuodar G., et al. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab Res Rev 22 (2006) 198-203
7. Dandona P., Thusu K., Cook S., Snyder B., Makowski J., Armstrong D., et al. Oxidative damage to DNA in diabetes mellitus. Lancet 347 (1996) 444-445
8. Seghrouchni I., Drai J., Bannier E., Riviere J., Calmard P., Garcia I., et al. Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency. Clin Chim Acta 321 (2002) 89-96
9. Ceriello A., Mercuri F., Quagliaro L., Assaloni R., Motz E., Tonutti L., et al. Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia 44 (2001) 834-838
10. Bohr V.A., and Anson R.M. DNA damage, mutation and fine structure DNA repair in aging. Mutat Res 338 (1995) 25-34
11. Vincent A.M., Brownlee M., and Russell J.W. Oxidative stress and programmed cell death in diabetic neuropathy. Ann N Y Acad Sci 959 (2002) 368-383
12. Kowluru R.A., Atasi L., and Ho Y.S. Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 47 (2006) 1594-1599
13. Devary Y., Rosette C., DiDonato J.A., and Karin M. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science 261 (1993) 1442-1445
14. Mohan N., and Meltz M.M. Induction of nuclear factor kB after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway. Radiat Res 140 (1994) 97-104
15. Schulze-Osthoff K., Los M., and Baeuerle P.A. Redox signaling by transcription factors NF-κB and AP-1 in lymphocytes. Biochem Pharmacol 50 (1995) 735-741
16. Kimura F., Hasegawa G., Obayashi H., Adachi T., Hara H., Ohta M., et al. Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications. Diabetes Care 26 (2003) 1246-1250
17. Zitouni K., Nourooz-Zadeh J., Harry D., Kerry S.M., Betteridge D.J., Capuccio F.P., et al. Race-specific differences in antioxidant enzyme activity in patients with type 2 diabetes: a potential association with the risk of developing nephropathy. Diabetes Care 28 (2005) 1698-1703
18. Kesavulu M.M., Giri R., Kameswara Rao B., and Apparao C. Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications. Diabetes Metab 26 (2000) 387-392
19. Bhatia S., Shukla R., Venkata Madhu S., Kaur Gambhir J., and Madhava Prabhu K. Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy. Clin Biochem 36 (2003) 557-562
20. Vucic M., Gavella M., Bozikov V., Aschcroft S.J., and Rocic B. Superoxide dismutase activity in lymphocytes and polymorphonuclear cells of diabetic patients. Eur J Clin Chem Clin Biochem 35 (1997) 517-521
21. Stephens J.W., Gable D.R., Hurel S.J., Miller G.J., Cooper J.A., and Humphries S.E. Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males. Clin Chem 52 (2006) 446-452
22. Ziegler D., Sohr C.G., and Nourooz-Zadeh J. Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy. Diabetes Care 27 (2004) 2178-2183
23. Dragsted L.O., Pedersen A., Hermetter A., Basu S., Hansen M., Haren G.R., et al. The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. Am J Clin Nutr 79 (2004) 1060-1072
24. Sen C. Oxidants and antioxidants in exercise. J Appl Physiol 79 (1995) 675-686
25. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 29 (2006) S43-S48
26. Gonzalo R., García-Arumí E., Lligé D., Martí R., Solano A., Montoya J., et al. Free radicals-mediated damage in transmitochondrial cells harboring the T14487C mutation in the ND6 gene of mtDNA. FEBS Lett 579 (2005) 6909-6913
27. Santos J.H., Mandavilli B.S., and Van Houten B. Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol Biol 197 (2002) 159-176
28. Kalinowski D., Illenye S., and Van Houten B. Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay. Nucleic Acid Res 20 (1992) 3485-3494
29. McCord J.M., and Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244 (1969) 6049-6055
30. Rustin P., Chretien D., Bourgeron T., Gerard B., Rötig A., Saudubray J.M., et al. Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 228 (1994) 35-51
31. Srere P.A. Citrate synthase. Methods Enzymol 13 (1969) 3-11
32. Nomiyama T., Tanaka Y., Hattori N., Nishimaki K., Nagasaka K., Kawamori R., et al. Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients. Diabetologia 45 (2002) 1577-1583
33. Kamiya J., and Aoki Y. Associations between hyperglycaemia and somatic transversion mutations in mitochondrial DNA of people with diabetes mellitus. Diabetologia 46 (2003) 1559-1566
34. Song J., Young J., Sung Y.A., Park Y.K., Park K.S., and Lee H.K. Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care 24 (2001) 865-869
35. Lee H.K., Song J.H., Shin C.S., Park D.J., Park K.S., Lee K.U., et al. Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 42 (1998) 161-167
36. Dincer Y., Akcay T., Ilkova H., Alademir Z., and Ozbay G. DNA damage and antioxidant defense in peripheral leukocytes of patients with type I diabetes mellitus. Mutat Res 527 (2003) 49-55
37. Pitozzi V., Giovannelli L., Bardini G., Rotella C.M., and Dolara P. Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes. Mutat Res 529 (2003) 129-133
38. Stitt A.W., Jenkins A.J., and Cooper M.E. Advanced glycation end products and diabetic complications. Expert Opin Investig Drugs 11 (2002) 1205-1223
39. Nath N., Chari S.N., and Rathi A.B. Superoxide dismutase in diabetic polymorphonuclear leukocytes. Diabetes 33 (1984) 586-589
40. Uchimura K., Nagasaka A., Hayashi R., Makino M., Nagata M., Kakizawa H., et al. Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus. J Diab Compl 13 (1999) 264-270
41. MacMillan-Crow L.A., and Cruthirds D.L. Manganese superoxide dismutase in disease. Free Radic Res 34 (2001) 325-336
42. Vives-Bauza C., Gonzalo R., Manfredi G., García-Arumí E., and Andreu A.L. Enhanced ROS production and antioxidant defenses in cybrids harbouring mutations in mtDNA. Neurosci Lett 391 (2006) 136-141
43. Shen X., Zheng S., Metrevell N.S., and Epstein P.N. Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes 55 (2006) 798-805
44. Kowluru R.A., Kowluru V., Xiong Y., and Ho Y.S. Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Free Radic Biol Med 41 (2006) 1191-1196
45. Boulet L., Karpati G., and Shoubridge E.A. Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF). Am J Hum Genet 51 (1992) 1187-1200
46. Sciacco M., Bonilla E., Schon E.A., DiMauro S., and Moraes C.T. Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy. Hum Mol Genet 3 (1994) 13-19