Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder

Journal of Physiological Sciences

Volumn 65, Issue 6, 2015, Pages 483-498

  Tanaka, Masaaki ^a   Tajima, Seiki ^b   Mizuno, Kei ^c   Ishii, Akira ^a   Konishi, Yukuo ^b   Miike, Teruhisa ^b   Watanabe, Yasuyoshi ^a,c  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Hyogo Children s Sleep and Development Medical Research Center Hyogo Rehabilitation Centre   (Japan)

^c RIKEN   (Japan)

Author keywords

Autonomic nervous system; Central nervous system; Circadian rhythm; Fatigue; Sleep

Indexed keywords

AUTONOMIC NEUROPATHY; CHRONIC FATIGUE SYNDROME; HUMAN; NEUROIMAGING; PATHOLOGY; SLEEP DISORDER;

AUTONOMIC NERVOUS SYSTEM DISEASES; FATIGUE SYNDROME, CHRONIC; HUMANS; NEUROIMAGING; SLEEP WAKE DISORDERS;

EID: 84945485200     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12576-015-0399-y     Document Type: Review

References (189)

1. Kanaya N, Hirata N, Kurosawa S, Nakayama M, Namiki A (2003) Differential effects of propofol and sevoflurane on heart rate variability. Anesthesiology 98:34–40
2. Takusagawa M, Komori S, Umetani K, Ishihara T, Sawanobori T, Kohno I, Sano S, Yin D, Ijiri H, Tamura K (1999) Alterations of autonomic nervous activity in recurrence of variant angina. Heart 82:75–81
3. No authors listed (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93:1043–1065
4. Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ (1981) Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 213:220–222
5. Pomeranz B, Macaulay RJ, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ et al (1985) Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 248:151–153
6. Malliani A, Pagani M, Lombardi F, Cerutti S (1991) Cardiovascular neural regulation explored in the frequency domain. Circulation 84:482–492
7. Appel ML, Berger RD, Saul JP, Smith JM, Cohen RJ (1989) Beat to beat variability in cardiovascular variables: noise or music? J Am Coll Cardiol 14:1139–1148
8. Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, Somers VK (1997) Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 95:1441–1448
9. Tanaka M, Mizuno K, Tajima S, Sasabe T, Watanabe Y (2009) Central nervous system fatigue alters autonomic nerve activity. Life Sci 84:235–239
10. Tanaka M, Mizuno K, Yamaguti K, Kuratsune H, Fujii A, Baba H, Matsuda K, Nishimae A, Takesaka T, Watanabe Y (2011) Autonomic nervous alterations associated with daily level of fatigue. Behav Brain Funct 7:46
11. Mizuno K, Tanaka M, Yamaguti K, Kajimoto O, Kuratsune H, Watanabe Y (2011) Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity. Behav Brain Funct 7:17
12. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP (1993) Development of a fatigue scale. J Psychosom Res 37:147–153
13. Tanaka M, Fukuda S, Mizuno K, Kuratsune H, Watanabe Y (2009) Stress and coping styles are associated with severe fatigue in medical students. Behav Med 35:87–92
14. Tanaka M, Fukuda S, Mizuno K, Imai-Matsumura K, Jodoi T, Kawatani J, Takano M, Miike T, Tomoda A, Watanabe Y (2008) Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan. Psychol Rep 103:682–690
15. Afari N, Buchwald D (2003) Chronic fatigue syndrome: a review. Am J Psychiatry 160:221–236
16. Wyller VB, Saul JP, Amlie JP, Thaulow E (2007) Sympathetic predominance of cardiovascular regulation during mild orthostatic stress in adolescents with chronic fatigue. Clin Physiol Funct Imaging 27:231–238
17. Burton AR, Rahman K, Kadota Y, Lloyd A, Vollmer-Conna U (2010) Reduced heart rate variability predicts poor sleep quality in a case–control study of chronic fatigue syndrome. Exp Brain Res 204:71–78
18. Yamaguti K, Sasabe T, Kuratsune H, Nishizawa Y, Watanabe Y (2008) J Therapy 90:537–547 (in Japanese)
19. Tomoda A, Mizuno K, Murayama N, Joudoi T, Igasaki T, Miyazaki M, Miike T (2007) Event-related potentials in Japanese childhood chronic fatigue syndrome. J Pediatr Neurol 5:199–208
20. Benarroch EE (1997) The central autonomic network. In: Low PA (ed) Clinical autonomic disorder, 2nd edn. Lippincott-Raven, Philadelphia
21. Loewy AD (1990) Central autonomic pathways. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford Univ Press, New York
22. Critchley HD, Mathias CJ, Josephs O, O’Doherty J, Zanini S, Dewar BK, Cipolotti L, Shallice T, Dolan RJ (2003) Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain 126:2139–2152
23. Koski L, Paus T (2000) Functional connectivity of the anterior cingulate cortex within the human frontal lobe: a brain-mapping meta-analysis. Exp Brain Res 133:55–65
24. Paus T, Castro-Alamancos MA, Petrides M (2001) Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation. Eur J Neurosci 14:1405–1411
25. Petrides M, Pandya DN (1999) Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. Eur J Neurosci 11:1011–1036
26. Vogt BA, Pandya DN (1987) Cingulate cortex of the rhesus monkey: II. Cortical afferents. J Comp Neurol 262:271–289
27. Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF (2005) Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat Neurosci 8:365–371
28. Thayer JF, Sternberg E (2006) Beyond heart rate variability: vagal regulation of allostatic systems. Ann N Y Acad Sci 1088:361–372
29. Thayer JF (2006) On the importance of inhibition: central and peripheral manifestations of nonlinear inhibitory processes in neural systems. Dose Response 4:2–21
30. Boksem MA, Meijman TF, Lorist MM (2006) Mental fatigue, motivation and action monitoring. Biol Psychol 72:123–132
31. Tanaka M, Sadato N, Okada T, Mizuno K, Sasabe T, Tanabe HC, Saito DN, Onoe H, Kuratsune H, Watanabe Y (2006) Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study. BMC Neurol 6:9
32. Mizuno K, Tanaka M, Tanabe HC, Sadato N, Watanabe Y (2012) The neural substrates associated with attentional resources and difficulty of concurrent processing of the two verbal tasks. Neuropsychologia 50:1998–2009
33. Tajima S, Yamamoto S, Tanaka M, Kataoka Y, Iwase M, Yoshikawa E, Okada H, Onoe H, Tsukada H, Kuratsune H, Ouchi Y, Watanabe Y (2010) Medial orbitofrontal cortex is associated with fatigue sensation. Neurol Res Int 2010:671421
34. Caseras X, Mataix-Cols D, Rimes KA, Giampietro V, Brammer M, Zelaya F, Chalder T, Godfrey E (2008) The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome. Psychol Med 38:941–951
35. Okada T, Tanaka M, Kuratsune H, Watanabe Y, Sadato N (2004) Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome. BMC Neurol 4:14
36. Mizuno K, Tajima K, Watanabe Y, Kuratsune H (2014) Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge. Behav Brain Funct 10:25
37. Mizuno K, Tanaka M, Fukuda S, Imai-Matsumura K, Watanabe Y (2011) Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students. Brain Dev 33:470–479
38. Tajima K, Tanaka M, Mizuno K, Okada N, Rokushima K, Watanabe Y (2008) Effects of bathing in micro-bubbles on recovery from moderate mental fatigue. Ergonomia IJE&HF 30:134–145
39. Watanabe Y, Sasabe T, Yamaguti K, Kobayashi M, Yamamoto S, Kuratsune H, Sano K, Hatanaka A, Tsukada H, Onoe H (2005) Prevention and/or recovery effects by green odor(s) on fatigue and green-odor-responsible brain regions as revealed by PET. Chem Senses Suppl 1:i268–i269
40. Sasabe T, Kobayashi M, Kondo Y, Onoe H, Matsubara S, Yamamoto S, Tsukada H, Onoe K, Watabe H, Iida H, Kogo M, Sano K, Hatanaka A, Sawada T, Watanabe Y (2003) Activation of the anterior cingulate gyrus by ‘Green Odor’: a positron emission tomography study in the monkey. Chem Senses 28:565–572
41. Morriss R, Sharpe M, Sharpley AL, Cowen PJ, Hawton K, Morris J (1993) Abnormalities of sleep in patients with the chronic fatigue syndrome. BMJ 306:1161–1164
42. Watson NF, Kapur V, Arguelles LM, Goldberg J, Schmidt DF, Armitage R, Buchwald D (2003) Comparison of subjective and objective measures of insomnia in monozygotic twins discordant for chronic fatigue syndrome. Sleep 26:324–328
43. Watson NF, Jacobsen C, Goldberg J, Kapur V, Buchwald D (2004) Subjective and objective sleepiness in monozygotic twins discordant for chronic fatigue syndrome. Sleep 27:973–977
44. Neu D, Mairesse O, Hoffmann G, Dris A, Lambrecht LJ, Linkowski P, Verbanck P, Le Bon O (2007) Sleep quality perception in the chronic fatigue syndrome: correlations with sleep efficiency, affective symptoms and intensity of fatigue. Neuropsychobiology 56:40–46
45. Armitage R, Landis C, Hoffmann R, Lentz M, Watson N, Goldberg J, Buchwald D (2009) Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome. J Psychosom Res 66:51–57
46. Rahman K, Burton A, Galbraith S, Lloyd A, Vollmer-Conna U (2011) Sleep-wake behavior in chronic fatigue syndrome. Sleep 34:671–678
47. Morriss RK, Wearden AJ, Battersby L (1997) The relation of sleep difficulties to fatigue, mood and disability in chronic fatigue syndrome. J Psychosom Res 42:597–605
48. Unger ER, Nisenbaum R, Moldofsky H, Cesta A, Sammut C, Reyes M, Reeves WC (2004) Sleep assessment in a population-based study of chronic fatigue syndrome. BMC Neurol 19:6
49. Kop WJ, Lyden A, Berlin AA, Ambrose K, Olsen C, Gracely RH, Williams DA, Clauw DJ (2005) Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome. Arthritis Rheum 52:296–303
50. Hossain JL, Reinish LW, Kayumov L, Bhuiya P, Shapiro CM (2003) Underlying sleep pathology may cause chronic high fatigue in shift-workers. J Sleep Res 12:223–230
51. Sharpley A, Clements A, Hawton K, Sharpe M (1997) Do patients with “pure” chronic fatigue syndrome (neurasthenia) have abnormal sleep? Psychosom Med 59:592–596
52. Stores G, Fry A, Crawford C (1998) Sleep abnormalities demonstrated by home polysomnography in teenagers with chronic fatigue syndrome. J Psychosom Res 45:85–91
53. Tajima S, Kuratsune H, Yamaguti K, Takahashi A, Takashima S, Watanabe Y, Nishizawa Y (2007) Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis. Nihon Rinsho 65:1057–1064 (in Japanese)
54. Ohinata J, Suzuki N, Araki A, Takahashi S, Fujieda K, Tanaka H (2008) Actigraphic assessment of sleep disorders in children with chronic fatigue syndrome. Brain Dev 30:329–333
55. Aerenhouts D, Ickmans K, Clarys P, Zinzen E, Meersdom G, Lambrecht L, Nijs J (2014) Sleep characteristics, exercise capacity and physical activity in patients with chronic fatigue syndrome. Disabil Rehabil 16:1–7
56. Ball N, Buchwald DS, Schmidt D, Goldberg J, Ashton S, Armitage R (2004) Monozygotic twins discordant for chronic fatigue syndrome: objective measures of sleep. J Psychosom Res 56:207–212
57. Fossey M, Libman E, Bailes S, Baltzan M, Schondorf R, Amsel R, Fichten CS (2004) Sleep quality and psychological adjustment in chronic fatigue syndrome. J Behav Med 27:581–605
58. Reeves WC, Heim C, Maloney EM, Youngblood LS, Unger ER, Decker MJ, Jones JF, Rye DB (2006) Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study. BMC Neurol 16:41
59. Guilleminault C, Poyares D, Rosa Ad, Kirisoglu C, Almeida T, Lopes MC (2006) Chronic fatigue, unrefreshing sleep and nocturnal polysomnography. Sleep Med 7:513–520
60. Kishi A, Struzik ZR, Natelson BH, Togo F, Yamamoto Y (2008) Dynamics of sleep stage transitions in healthy humans and patients with chronic fatigue syndrome. Am J Physiol Regul Integr Comp Physiol 294:R1980–R1987
61. Decker MJ, Tabassum H, Lin JM, Reeves WC (2009) Electroencephalographic correlates of chronic fatigue syndrome. Behav Brain Funct 6:43
62. Neu D, Cappeliez B, Hoffmann G, Verbanck P, Linkowski P, Le Bon O (2009) High slow-wave sleep and low-light sleep: chronic fatigue syndrome is not likely to be a primary sleep disorder. J Clin Neurophysiol 26:207–212
63. Le Bon O, Neu D, Berquin Y, Lanquart JP, Hoffmann R, Mairesse O, Armitage R (2012) Ultra-slow delta power in chronic fatigue syndrome. Psychiatry Res 200:742–747
64. Neu D, Mairesse O, Verbanck P, Le Bon O (2015) Slow wave sleep in the chronically fatigued: Power spectra distribution patterns in chronic fatigue syndrome and primary insomnia. Clin Neurophysiol. doi:10.1016/j.clinph.2014.12.016
65. Kishi A, Natelson BH, Togo F, Struzik ZR, Rapoport DM, Yamamoto Y (2011) Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia. Sleep 34:1551–1560
66. Gotts ZM, Deary V, Newton J, Van der Dussen D, De Roy P, Ellis JG (2013) Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis. BMJ Open. doi:10.1136/bmjopen-2013-002999
67. Mariman A, Vogelaers D, Hanoulle I, Delesie L, Pevernagie D (2012) Subjective sleep quality and daytime sleepiness in a large sample of patients with chronic fatigue syndrome (CFS). Acta Clin Belg 67:19–24
68. Togo F, Natelson BH, Cherniack NS, FitzGibbons J, Garcon C, Rapoport DM (2008) Sleep structure and sleepiness in chronic fatigue syndrome with or without coexisting fibromyalgia. Arthritis Res Ther 10:R56
69. Ohashi K, Yamamoto Y, Natelson BH (2002) Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome. Physiol Behav 77:39–44
70. Togo F, Natelson BH, Cherniack NS, Klapholz M, Rapoport DM, Cook DB (2010) Sleep is not disrupted by exercise in patients with chronic fatigue syndromes. Med Sci Sports Exerc 42:16–22
71. Kishi A, Togo F, Cook DB, Klapholz M, Yamamoto Y, Rapoport DM, Natelson BH (2013) The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome. Physiol Rep 1:e00152
72. Tomoda A, Miike T, Uezono K, Kawasaki T (1994) A school refusal case with biological rhythm disturbance and melatonin therapy. Brain Dev 16:71–76
73. van Heukelom RO, Prins JB, Smits MG, Bleijenberg G (2006) Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur J Neurol 13:55–60
74. Williams G, Pirmohamed J, Minors D, Waterhouse J, Buchan I, Arendt J, Edwards RH (1996) Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome. Clin Physiol 16:327–337
75. Tomoda A, Miike T, Yonamine K, Adachi K, Shiraishi S (1997) Disturbed circadian core body temperature rhythm and sleep disturbance in school refusal children and adolescents. Biol Psychiatry 41:810–813
76. Hamilos DL, Nutter D, Gershtenson J, Ikle D, Hamilos SS, Redmond DP, Di Clementi JD, Schmaling KB, Jones JF (2001) Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome. Clin Physiol 21:184–195
77. Ohashi K, Bleijenberg G, van der Werf S, Prins J, Amaral LA, Natelson BH, Yamamoto Y (2004) Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome. Methods Inf Med 43:26–29
78. Tajima S (2009) Physiological fatigue estimation using physical activity analysis. Igaku No Ayumi 228:640–645 (in Japanese)
79. Kawabata M, Ueno T, Tomita J, Kawatani J, Tomoda A, Kume S, Kume K (2013) Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children. BMC Psychiatry 13:281
80. Takimoto M, Hamada A, Tomoda A, Ohdo S, Ohmura T, Sakato H, Kawatani J, Jodoi T, Nakagawa H, Terazono H, Koyanagi S, Higuchi S, Kimura M, Tukikawa H, Irie S, Saito H, Miike T (2005) Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder. Am J Physiol Regul Integr Comp Physiol 289:R1273–R1279
81. Boneva RS, Decker MJ, Maloney EM, Lin JM, Jones JF, Helgason HG, Heim CM, Rye DB, Reeves WC (2007) Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study. Auton Neurosci 137:94–101
82. Yamaguti K, Tajima S, Kuratsune H (2013) Autonomic dysfunction in chronic fatigue syndrome. Adv Neuroimmun Biol 4:281–289
83. Tomoda A, Miike T, Honda T, Fukuda K, Kai Y, Nabeshima M, Takahashi M (1995) Single-photon emission computed tomography for cerebral blood flow in school phobia. Curr Ther Res 56:1088–1093
84. Tomoda A, Miike T, Yamada E, Honda H, Moroi T, Ogawa M, Ohtani Y, Morishita S (2000) Chronic fatigue syndrome in childhood. Brain Dev 22:60–64
85. Gotts ZM, Ellis JG, Deary V, Barclay N, Newton JL (2015) The association between daytime napping and cognitive functioning in chronic fatigue syndrome. PLoS One 10:e0117136. doi:10.1371/journal.pone.0117136
86. Richards RS, Roberts TK, McGregor NR, Dunstan RH, Butt HL (2000) Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome. Redox Rep 5:35–41
87. Tomoda A, Joudoi T, el-M Rabab, Matsumoto T, Park TH, Miike T (2005) Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls. Psychiatry Res 134:101–104
88. Nakamura T, Schwander S, Donnelly R, Cook DB, Ortega F, Togo F, Yamamoto Y, Cherniack NS, Klapholz M, Rapoport D, Natelson BH (2013) Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome. Clin Vaccine Immunol 20:1736–1742
89. Iwatani N, Miike T, Kai Y, Kodama M, Mabe H, Tomoda A, Fukuda K, Jyodoi T (1997) Glucoregulatory disorders in school refusal students. Clin Endocrinol 47:273–278
90. Taylor JL, Gandevia SC (2008) A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions. J Appl Physiol 104:542–550
91. Taylor JL, Butler JE, Allen GM, Gandevia SC (1996) Changes in motor cortical excitability during human muscle fatigue. J Physiol 490:519–528
92. Johnston J, Rearick M, Slobounov S (2001) Movement-related cortical potentials associated with progressive muscle fatigue in a grasping task. Clin Neurophysiol 112:68–77
93. Liu JZ, Lewandowski B, Karakasis C, Yao B, Siemionow V, Sahgal V, Yue GH (2007) Shifting of activation center in the brain during muscle fatigue: an explanation of minimal central fatigue? Neuroimage 35:299–307
94. Dettmers C, Lemon RN, Stephan KM, Fink GR, Frackowiak RS (1996) Cerebral activation during the exertion of sustained static force in man. Neuroreport 7:2103–2110
95. Korotkov A, Radovanovic S, Ljubisavljevic M, Lyskov E, Kataeva G, Roudas M, Pakhomov S, Thunberg J, Medvedev S, Johansson H (2005) Comparison of brain activation after sustained non-fatiguing and fatiguing muscle contraction: a positron emission tomography study. Exp Brain Res 163:65–74
96. Liu JZ, Shan ZY, Zhang LD, Sahgal V, Brown RW, Yue GH (2003) Human brain activation during sustained and intermittent submaximal fatigue muscle contractions: an FMRI study. J Neurophysiol 90:300–312
97. Benwell NM, Mastaglia FL, Thickbroom GW (2006) Reduced functional activation after fatiguing exercise is not confined to primary motor areas. Exp Brain Res 175:575–583
98. Benwell NM, Mastaglia FL, Thickbroom GW (2007) Changes in the functional MR signal in motor and non-motor areas during intermittent fatiguing hand exercise. Exp Brain Res 18:93–97
99. Post M, Steens A, Renken R, Maurits NM, Zijdewind I (2009) Voluntary activation and cortical activity during a sustained maximal contraction: an fMRI study. Hum Brain Mapp 30:1014–1027
100. Logothetis NK (2008) What we can do and what we cannot do with fMRI. Nature 453:869–878
101. Shibasaki H (2008) Human brain mapping: hemodynamic response and electrophysiology. Clin Neurophysiol 119:731–743
102. Tanji J, Okano K, Sato KC (1988) Neuronal activity in cortical motor areas related to ipsilateral, contralateral, and bilateral digit movements of the monkey. J Neurophysiol 60:325–343
103. Tanaka M, Ishii A, Watanabe Y (2013) Neural mechanism of facilitation system during physical fatigue. PLoS One 8:80731
104. Tanaka M, Watanabe Y (2011) Neural compensation mechanisms to regulate motor output during physical fatigue. Brain Res 1395:46–52
105. Tanaka M, Ishii A, Watanabe Y (2014) Regulatory mechanism of performance in chronic cognitive fatigue. Med Hypotheses 82:567–571
106. Alexander GE, Crutcher MD (1990) Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 13:266–271
107. Tanaka M, Watanabe Y (2012) Supraspinal regulation of physical fatigue. Neurosci Biobehav Rev 36:727–734
108. Desmond P, Hancock P (2001) Active and passive fatigue states. In: Hancock P, Desmond P (eds) Stress, workload, and fatigue. Lawrence Erlbaum Associates, New Jersey
109. Matthews G, Desmond PA (2002) Task-induced fatigue states and simulated driving performance. Q J Exp Psychol A 55:659–686
110. Mizuno K, Watanabe Y (2007) Utility of an advanced trail making test as a neuropsychological tool for an objective evaluation of work efficiency during mental fatigue. In: Watanabe Y, Evengård B, Natelson B, Jason L, Kuratsune H (eds) Fatigue science for human health. Springer, New York
111. Tanaka M, Ishii A, Watanabe Y (2014) Neural effects of mental fatigue caused by continuous attention load: a magnetoencephalography study. Brain Res 1561:60–66
112. Ishii A, Tanaka M, Shigihara Y, Kanai E, Funakura M, Watanabe Y (2013) Neural effects of prolonged mental fatigue: a magnetoencephalography study. Brain Res 1529:105–112
113. Shigihara Y, Tanaka M, Ishii A, Tajima S, Kanai E, Funakura M, Watanabe Y (2013) Two different types of mental fatigue produce different styles of task performance. Neurol Psychiatr Brain Res 19:5–11
114. Shigihara Y, Tanaka M, Ishii A, Kanai E, Funakura M, Watanabe Y (2013) Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways. Behav Brain Funct 9:2
115. Tanaka M, Ishii A, Shigihara Y, Tajima S, Funakura M, Kanai E, Watanabe Y (2012) Impaired selective attention caused by mental fatigue. J Neurol Sci (Turkish) 29:542–553
116. Tanaka M, Shigihara Y, Ishii A, Funakura M, Kanai E, Watanabe Y (2012) Effect of mental fatigue on the central nervous system: an electroencephalography study. Behav Brain Funct 8:48
117. Kuratsune D, Tajima S, Koizumi J, Yamaguti K, Sasabe T, Mizuno K, Tanaka M, Okawa N, Mito H, Tsubone H, Watanabe Y, Inoue M, Kuratsune H (2012) Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers. World J Neurosci 2:113–118
118. Shigihara Y, Tanaka M, Watanabe Y (2010) Relationship between fatigue and photosensitivity. Behav Med 36:109–112
119. Kajimoto O (2007) Development of a method of evaluation of fatigue and its economic impacts. In: Watanabe Y, Evengård B, Natelson B, Jason L, Kuratsune H (eds) Fatigue science for human health. Springer, New York
120. Johnson SA, Yechiam E, Murphy RR, Queller S, Stout JC (2006) Motivational processes and autonomic responsivity in Asperger’s disorder: evidence from the Iowa Gambling Task. JINS 12:668–676
121. Mezzacappa E, Kindlon D, Saul JP, Earls F (1998) Executive and motivational control of performance task behavior, and autonomic heart-rate regulation in children: physiologic validation of two-factor solution inhibitory control. J Child Psychol Psychiatry 39:525–531
122. Brookes MJ, Wood JR, Stevenson CM, Zumer JM, White TP, Liddle PF, Morris PG (2011) Changes in brain network activity during working memory tasks: a magnetoencephalography study. Neuroimage 55:1804–1815
123. Varela F, Lachaux JP, Rodriguez E, Martinerie J (2001) The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2:229–239
124. Lopes da Silva F (1991) Neural mechanisms underlying brain waves: from neural membranes to networks. Electroencephalogr Clin Neurophysiol 79:81–93
125. Rinzel J, Terman D, Wang X, Ermentrout B (1998) Propagating activity patterns in large-scale inhibitory neuronal networks. Science 279:1351–1355
126. Yanagisawa H, Dan I, Tsuzuki D, Kato M, Okamoto M, Kyutoku Y, Soya H (2010) Acute moderate exercise elicits increased dorsolateral prefrontal activation and improves cognitive performance with Stroop test. Neuroimage 50:1702–1710
127. Tanaka M, Ishii A, Watanabe Y (2014) Neural effect of mental fatigue on physical fatigue: a magnetoencephalography study. Brain Res 1542:49–55
128. Boksem MA, Tops M (2008) Mental fatigue: costs and benefits. Brain Res Rev 59:125–139
129. Lim J, Wu WC, Wang J, Detre JA, Dinges DF, Rao H (2010) Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect. Neuroimage 49:3426–3435
130. Ishii A, Tanaka M, Watanabe Y (2014) Neural mechanisms of mental fatigue. Rev Neurosci 25:469–479
131. Smith EE, Jonides J (1999) Storage and executive processes in the frontal lobes. Science 283:1657–1661
132. Carter CS, van Veen V (2007) Anterior cingulate cortex and conflict detection: an update of theory and data. Cogn Affect Behav Neurosci 7:367–379
133. Chaudhuri A, Behan PO (2000) Fatigue and basal ganglia. J Neurol Sci 179:34–42
134. Chaudhuri A, Behan PO (2004) Fatigue in neurological disorders. Lancet 363:978–988
135. 18F-fluorodeoxyglucose positron emission tomography study. Neurology 48:1566–1571
136. Filippi M, Rocca MA, Colombo B, Falini A, Codella M, Scotti G, Comi G (2002) Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis. Neuroimage 15:559–567
137. White AT, Lee JN, Light AR, Light KC (2009) Brain activation in multiple sclerosis: a BOLD fMRI study of the effects of fatiguing hand exercise. Mult Scler 15:580–586
138. Sisto SA, LaManca J, Cordero DL, Bergen MT, Ellis SP, Drastal S, Boda WL, Tapp WN, Natelson BH (1996) Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome. Am J Med 100:634–640
139. Gibson H, Carroll N, Clague JE, Edwards RH (1993) Exercise performance and fatiguability in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 56:993–998
140. Chaudhuri A, Condon BR, Gow JW, Brennan D, Hadley DM (2003) Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. Neuroreport 14:225–228
141. Kuratsune H, Yamaguti K, Lindh G, Evengård B, Hagberg G, Matsumura K, Iwase M, Onoe H, Takahashi M, Machii T, Kanakura Y, Kitani T, Långström B, Watanabe Y (2002) Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain. Neuroimage 17:1256–1265
142. Siessmeier T, Nix WA, Hardt J, Schreckenberger M, Egle UT, Bartenstein P (2003) Observer independent analysis of cerebral glucose metabolism in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 74:922–928
143. de Lange FP, Koers A, Kalkman JS, Bleijenberg G, Hagoort P, van der Meer JW, Toni I (2008) Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with chronic fatigue syndrome. Brain 131:2172–2180
144. Tirelli U, Chierichetti F, Tavio M, Simonelli C, Bianchin G, Zanco P, Ferlin G (1998) Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data. Am J Med 105:54–58
145. Shigihara Y, Tanaka M, Mizuno K, Ishii A, Yamano E, Funakura M, Kanai E, Watanabe Y (2012) Effects of daily levels of fatigue and acutely induced fatigue on the visual evoked magnetic response. Brain Res 1457:44–50
146. Tanaka M, Shigihara Y, Funakura M, Kanai E, Watanabe Y (2012) Fatigue-associated alterations of cognitive function and electroencephalographic power densities. PLoS One 7:34774
147. Shigihara Y, Tanaka M, Tsuyuguchi N, Tanaka H, Watanabe Y (2010) Hazardous nature of high-temporal-frequency strobe light stimulation: neural mechanisms revealed by magnetoencephalography. Neuroscience 166:482–490
148. Tanaka M, Ishii A, Watanabe Y (2014) Hazardous effects of light stimulation in the central nervous system. Austin J Clin Neurol 1:4
149. Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431–1568
150. Yamano E, Tanaka M, Ishii A, Tsuruoka N, Abe K, Watanabe Y (2013) Effects of chicken essence on recovery from mental fatigue in healthy males. Med Sci Monit 19:540–547
151. Mizuma H, Tanaka M, Nozaki S, Mizuno K, Tahara T, Ataka S, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (2009) Daily oral administration of crocetin attenuates physical fatigue in human. Nutr Res 29:145–150
152. Tanaka M, Baba Y, Kataoka Y, Kinbara N, Sagesaka YM, Kakuda T, Watanabe Y (2008) Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue. Nutrition 24:599–603
153. Tanaka M, Watanabe Y (2008) Reduced energy utilization in the brain is a feature of an animal model of fatigue. Int J Neurosci 118:683–692
154. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (2008) Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition 24:293–299
155. Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (2008) Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition 24:233–238
156. Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (2007) Effects of Applephenon and ascorbic acid on physical fatigue. Nutrition 23:419–423
157. 18F]fluoro-2-deoxy-d-glucose utilization measured by autoradiography and in brain monoamine levels of rat. Neurosci Lett 353:169–172
158. Tanaka M, Nakamura F, Mizokawa S, Matsumura A, Nozaki S, Watanabe Y (2003) Establishment and assessment of a rat model of fatigue. Neurosci Lett 352:159–162
159. Arnett SV, Alleva LM, Korossy-Horwood R, Clark IA (2011) Chronic fatigue syndrome—a neuroimmunological model. Med Hypotheses 77:77–83
160. Pall ML (2000) Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. Med Hypotheses 54:115–125
161. Tanaka M, Ishii A, Watanabe Y (2015) Fatigue in the central nervous system. Austin J Clin Neurol 2:1020
162. Tanaka M, Ishii A, Watanabe Y (2013) Neural dysfunction in chronic fatigue syndrome. Adv Neuroimmune Biol 4:291–300
163. Tanaka M, Ishii A, Watanabe Y (2013) Neural mechanisms underlying chronic fatigue. Rev Neurosci 24:617–628
164. Tanaka M, Watanabe Y (2012) Risk-management syndrome. Int J Psychiatry Clin Pract 16:312–315
165. Tanaka M, Watanabe Y (2010) A new hypothesis of chronic fatigue syndrome: co-conditioning theory. Med Hypotheses 75:244–249
166. Ishii A, Tanaka M, Yamano E, Watanabe Y (2012) Neural substrates activated by viewing others expressing fatigue: a magnetoencephalography study. Brain Res 1455:68–74
167. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G (2003) Both of us disgusted in My insula: the common neural basis of seeing and feeling disgust. Neuron 40:655–664
168. Singer T, Seymour B, O’Doherty J, Kaube H, Dolan RJ, Frith CD (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303:1157–1162
169. Botvinick M, Jha AP, Bylsma LM, Fabian SA, Solomon PE, Prkachin KM (2005) Viewing facial expressions of pain engages cortical areas involved in the direct experience of pain. Neuroimage 25:312–319
170. Jabbi M, Swart M, Keysers C (2007) Empathy for positive and negative emotions in the gustatory cortex. Neuroimage 34:1744–1753
171. Cheng Y, Yang CY, Lin CP, Lee PL, Decety J (2008) The perception of pain in others suppresses somatosensory oscillations: a magnetoencephalography study. Neuroimage 40:1833–1840
172. Fabbri-Destro M, Rizzolatti G (2008) Mirror neurons and mirror systems in monkeys and humans. Physiology (Bethesda) 23:171–179
173. Bastiaansen JA, Thioux M, Keysers C (2009) Evidence for mirror systems in emotions. Philos Trans R Soc Lond B Biol Sci 364:2391–2404
174. Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE, Prigatano GP (2002) Neural correlates of self-reflection. Brain 125:1808–1814
175. Vogt BA, Laureys S (2005) Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Prog Brain Res 150:205–217
176. Vogt BA, Vogt L, Laureys S (2006) Cytology and functionally correlated circuits of human posterior cingulate areas. Neuroimage 29:452–466
177. Ishii A, Tanaka M, Yamano E, Watanabe Y (2014) The neural substrates of physical fatigue sensation to evaluate ourselves: a magnetoencephalography study. Neuroscience 261:60–67
178. Ishii A, Tanaka M, Watanabe Y (2014) The neural substrates of self-evaluation of mental fatigue: a magnetoencephalography study. PLoS One 9:e95763
179. Ishii A, Tanaka M, Watanabe Y (2014) The neural mechanisms underlying the decision to rest in the presence of fatigue: a magnetoencephalography study. PLoS One 9:e109740
180. Otto T, Zijlstra FR, Goebel R (2013) Neural correlates of mental effort evaluation– involvement of structures related to self-awareness. Soc Cogn Affect Neurosci 9:307–315
181. Katafuchi T (2004) Conditioning of fatigue and serotonin system. Mol Med 41:1264–1268 (in Japanese)
182. Katafuchi T, Kondo T, Yasaka T, Kubo K, Take S, Yoshimura M (2003) Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue. Neuroscience 120:837–845
183. Katafuchi T, Kondo T, Take S, Yoshimura M (2005) Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. Eur J Neurosci 22:2817–2826
184. Katafuchi T, Kondo T, Take S, Yoshimura M (2006) Brain cytokines and the 5-HT system during poly I:C-induced fatigue. Ann N Y Acad Sci 1088:230–237
185. Ishii A, Tanaka M, Iwamae M, Kim C, Yamano E, Watanabe Y (2013) Fatigue sensation induced by the sounds associated with mental fatigue and its related neural activities: revealed by magnetoencephalography. Behav Brain Funct 9:24
186. Tanaka M, Ishii A, Watanabe Y (2013) Neural correlates of central inhibition during physical fatigue. PLoS One 8:e70949
187. Koyama H, Fukuda S, Shoji T, Inaba M, Tsujimoto Y, Tabata T, Okuno S, Yamakawa T, Okada S, Okamura M, Kuratsune H, Fujii H, Hirayama Y, Watanabe Y, Nishizawa Y (2010) Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis. Clin J Am Soc Nephrol 5:659–666
188. Covanis A, Stodieck SR, Wilkins AJ (2004) Treatment of photosensitivity. Epilepsia 45:40–45
189. Uehata T (2005) Nippon Rinsho 63:1249–1253 (in Japanese)