Propagating activity patterns in large-scale inhibitory neuronal networks

Science

Volumn 279, Issue 5355, 1998, Pages 1351-1355

  Rinzel, J ^a,e,f   Terman, D ^b   Wang, X J ^c   Ermentrout, B ^d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c BRANDEIS UNIVERSITY   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e NEW YORK UNIVERSITY   (United States)

^f NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DEPOLARIZATION; GABAERGIC TRANSMISSION; MEMBRANE CONDUCTANCE; NERVE CELL NETWORK; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; SYNAPTIC POTENTIAL;

FEEDBACK; GAMMA-AMINOBUTYRIC ACID; INTERNEURONS; MEMBRANE POTENTIALS; MODELS, NEUROLOGICAL; NERVE NET; NEURAL INHIBITION; RECRUITMENT, NEUROPHYSIOLOGICAL; SYNAPSES; SYNAPTIC TRANSMISSION; THALAMUS;

EID: 0032570706     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5355.1351     Document Type: Article

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19. syn = -85 (in mV). For numerically solving the model's equations, we approximate the continuum formulation by discretizing in space, using N cells equally distributed along the network's length L (arbitrarily chosen as 2 mm); N = 200 unless stated otherwise. The spatially discretized version is numerically integrated in time using a second-order modified-Euler method with δt = 0.5 ms. Accuracy was confirmed by achieving agreement after adequately refining the temporal and spatial discretizations.
20. The model's spatiotemporal activity can be dynamically visualized over the Internet by using an MPEG-capable browser, opening the Web site http.//www. pitt.edu/~phase, and going to the section "Movies of waves in a simple PIR inhibitorily coupled network."
21. J. Rinzel, D. Terman, X.-J. Wang, B. Ermentrout, data not shown.
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37. A currents.
38. A currents.
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40. app is on the left branch and is therefore stable.
41. Supported by the Alfred P. Sloan Foundation, NSF grants DMS-9203299 and DMS-9626728, NIH grants MH53717-01 and MH 47150, and the W. M. Keck Foundation.