Chronic fatigue syndrome: A review

American Journal of Psychiatry

Volumn 160, Issue 2, 2003, Pages 221-236

  Afari, Niloofar ^a,b   Buchwald, Dedra ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; BEHAVIOR THERAPY; CHRONIC FATIGUE SYNDROME; CLINICAL EXAMINATION; CLINICAL FEATURE; COGNITIVE THERAPY; COMORBIDITY; COPING BEHAVIOR; DISABILITY; DISEASE DURATION; EXERCISE; FAMILIAL DISEASE; FUNCTIONAL DISEASE; HUMAN; MENTAL DISEASE; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SYMPTOM; ADAPTIVE BEHAVIOR; ADOLESCENT; ADULT; CASE CONTROL STUDY; CHILD; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; FEMALE; MALE; PATIENT ADVOCACY; SELF HELP;

ADAPTATION, PSYCHOLOGICAL; ADOLESCENT; ADULT; BEHAVIOR THERAPY; CASE-CONTROL STUDIES; CHILD; CONTROLLED CLINICAL TRIALS; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; MALE; PATIENT ADVOCACY; PROGNOSIS; SELF-HELP GROUPS;

EID: 0037313180     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.2.221     Document Type: Review

References (230)

1. Chen M: The epidemiology of self-perceived fatigue among adults. Prev Med 1986; 15:74-81
2. Pawlikowska T, Chalder T, Hirsch SR, Wallace P, Wright DJ, Wessely SC: Population based study of fatigue and psychological distress. Br Med J 1994; 308:763-766
3. Bates D, Schmitt W, Buchwald D, Ware NC, Lee J, Thoyer E, Kornish RJ, Komaroff AL: Prevalence of fatigue and chronic fatigue syndrome in a primary care practice. Arch Intern Med 1993; 153:2759-2765
4. Cathebras PJ, Robbins JM, Kirmayer LJ, Hayton BC: Fatigue in primary care: prevalence, psychiatric comorbidity, illness behavior, and outcome. J Gen Intern Med 1992; 7:276-286
5. David A, Pelosi A, McDonald E, Stephens D, Ledger D, Rathbone R, Mann A: Tired, weak, or in need of rest: a profile of fatigue among general practice attenders. Br Med J 1990; 301:1199-1202
6. Kroenke K, Wood DR, Mangelsdorff D, Meier NJ, Powell JB: Chronic fatigue in primary care: prevalence, patient characteristics, and outcome. JAMA 1988; 260:929-934
7. McDonald E, David AS, Pelosi AJ, Mann AH: Chronic fatigue in primary care attenders. Psychol Med 1993; 23:987-998
8. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A: The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994; 121:953-959
9. Bombardier CH, Buchwald D: Chronic fatigue, chronic fatigue syndrome, and fibromyalgia: disability and health-care use. Med Care 1996; 34:924-930
10. Buchwald D, Pearlman T, Umali J, Schmaling K, Katon W: Functional status in patients with chronic fatigue syndrome, other fatiguing illnesses, and healthy individuals. Am J Med 1996; 101:364-370
11. Briggs NC, Levine PH: A comparative review of systemic and neurological symptomatology in 12 outbreaks collectively described as chronic fatigue syndrome, epidemic neuromyasthenia, and myalgic encephalomyelitis. Clin Infect Dis 1994; 18(suppl 1):S32-S42
12. Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, Dubois RE, Cunningham-Rundles C, Pahwa S: Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988; 108:387-389
13. Goshorn RK: Chronic fatigue syndrome: a review for clinicians. Semin Neurol 1998; 18:237-242
14. Sharpe MC, Archard LC, Banatvala JE, Borysiewicz LK, Clare AW, David A, Edwards RH, Hawton KE, Lambert HP, Lane RJ: A report - chronic fatigue syndrome: guidelines for research. J R Soc Med 1991; 84:118-121
15. Lloyd AR, Hickie I, Boughton CR, Spencer O, Wakefield D: Prevalence of the chronic fatigue syndrome in an Australian population. Med J Aust 1990; 153:522-528
16. Richman JA, Flaherty JA, Rospenda KM: Chronic fatigue syndrome: have flawed assumptions been derived from treatment-based studies? Am J Public Health 1994; 84:282-284
17. Jason LA, Richman JA, Rademaker AW, Jordan KM, Plioplys AV, Taylor RR, McCready W, Huang CF, Plioplys S: A community-based study of chronic fatigue syndrome. Arch Intern Med 1999; 159:2129-2137
18. Steele L, Dobbins JG, Fukuda K, Reyes M, Randall B, Koppelman M, Reeves WC: The epidemiology of chronic fatigue in San Francisco. Am J Med 1998; 105:83S-90S
19. Fukuda K, Dobbins JG, Wilson LJ, Dunn RA, Wilcox K, Smallwood D: An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome. J Psychiatr Res 1997; 31:19-29
20. Wessely S, Chalder T, Hirsch S, Wallace P, Wright D: The prevalence and morbidity of chronic fatigue and the chronic fatigue syndrome: a prospective primary care study. Am J Public Health 1997; 87:1449-1455
21. Reyes M, Gary HE Jr, Dobbins JG, Randall B, Steele L, Fukuda K, Holmes GP, Connell DG, Mawle AC, Schmid S, Stewart JA, Schonberger LB, Gunn WJ, Reeves WC: Surveillance for chronic fatigue syndrome - four US cities, September 1989 through August 1993. MMWR Surveill Summ 1997; 46:1-13
22. Buchwald D, Umali P, Umali J, Kith P, Pearlman T, Komaroff AL: Chronic fatigue and the chronic fatigue syndrome in a Pacific Northwest health care system. Ann Intern Med 1995; 123:81-88
23. Jordan KM, Landis DA, Downey MC, Osterman SL, Thurm AE, Jason LA: Chronic fatigue syndrome in children and adolescents: a review. J Adolesc Health 1998; 22:4-18
24. MacDonald KL, Osterholm MT, LeDell KH, White KE, Schenck CH, Chao CC, Persing DH, Johnson RC, Barker JM, Peterson PK: A case-control study to assess possible triggers and cofactors in chronic fatigue syndrome. Am J Med 1996; 100:548-554
25. Salit IE: Precipitating factors for the chronic fatigue syndrome. J Psychiatr Res 1997; 31:59-65
26. Schluederberg A, Straus SE, Peterson P, Blumenthal S, Komaroff AL, Spring SB, Landay A, Buchwald D: Chronic fatigue syndrome research: definition and medical outcome assessment. Ann Intern Med 1992; 117:325-331
27. Komaroff AL, Fagioli LR, Geiger AM, Doolittle TH, Lee J, Kornish RJ, Gleit MA, Guerriero RT: An examination of the working case definition of chronic fatigue syndrome. Am J Med 1996; 100:56-64
28. Jason LA, Taylor RR, Kennedy CL, Jordan K, Song S, Johnson DE, Torres SR: Chronic fatigue syndrome: sociodemographic subtypes in a community-based sample. Eval Health Prof 2000; 23:246-262
29. Jason LA, Taylor RR, Kennedy CL: Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms. Psychosom Med 2000; 62:655-663
30. Aaron LA, Burke MM, Buchwald D: Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Arch Intern Med 2000; 160:221-227
31. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P: The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 1990; 33:60-72
32. Buchwald D, Garrity D: Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities. Arch Intern Med 1994; 154:2049-2053
33. Hudson Jl, Goldenberg DL, Pope HG, Keck PE, Schlesinger L: Comorbidity of fibromyalgia with medical and psychiatric disorders. Am J Med 1992; 92:363-367
34. White KP, Speechley M, Harth M, Ostbye T: Co-existence of chronic fatigue syndrome with fibromyalgia syndrome in the general population - a controlled study. Scand J Rheumatol 2000; 29:44-51
35. Goldenberg DL, Simms RW, Geiger A, Komaroff AL: High frequency of fibromyalgia in patients with chronic fatigue seen in primary care practice. Arthritis Rheum 1990; 33:381-387
36. Wessely S, Nimnuan C, Sharpe M: Functional somatic syndromes: one or many? Lancet 1999; 354:936-939
37. Hudson JI, Pope HG Jr: Affective spectrum disorder: does antidepressant response identify a family of disorders with a common pathophysiology? Am J Psychiatry 1990; 147:552-564
38. Komaroff AL, Buchwald DS: Chronic fatigue syndrome: an update. Annu Rev Med 1998; 49:1-13
39. White PD: The relationship between infection and fatigue. J Psychosom Res 1997; 43:345-350
40. Walsh CM, Zainal NZ, Middleton SJ, Paykel ES: A family history study of chronic fatigue syndrome. Psychiatr Genet 2001; 11:123-128
41. Hickie I, Bennett B, Lloyd A, Heath A, Martin N: Complex genetic and environmental relationships between psychological distress, fatigue and immune functioning: a twin study. Psychol Med 1999; 29:269-277
42. Hickie I, Kirk K, Martin N: Unique genetic and environmental determinants of prolonged fatigue: a twin study. Psychol Med 1999; 29:259-268
43. Farmer A, Scourfield J, Martin N, Cardeno A, McGuffin P: Is disabling fatigue in childhood influenced by genes? Psychol Med 1999; 29:279-282
44. Buchwald D, Herrell R, Ashton S, Belcourt M, Schmaling K, Goldberg J: A twin study of chronic fatigue. Psychosom Med 2001; 63:936-943
45. Vogler GP, McClearn GE, Snieder H, Boomsma DI, Palmer R, de Knijff P, Slagboom PE: Genetics and behavioral medicine: risk factors for cardiovascular disease. Behav Med 1997; 22:141-149
46. Sullivan PF, Neale MC, Kendler KS: Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000; 157:1552-1562
47. Natelson BH, Cohen JM, Brassloff I, Lee HJ: A controlled study of brain magnetic resonance imaging in patients with fatiguing illnesses. J Neurol Sci 1993; 120:213-217
48. Buchwald D, Cheney PR, Peterson DL, Henry B, Wormsley SB, Geiger A, Ablashi DV, Salahuddin SZ, Saxinger C, Biddle R, Kikinis R, Jolesz FA, Folks T, Balachandran N, Peter JB, Gallo RC, Komaroff AL: A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann Intern Med 1992; 116:103-113
49. Lange G, DeLuca J, Maldjian JA, Lee HJ, Tiersky LA, Natelson BH: Brain MRI abnormalities exist in a subset of patients with chronic fatigue syndrome. J Neurol Sci 1999; 171:3-7
50. Schwartz RB, Garada BM, Komaroff AL, Tice HM, Gleit M, Jolesz FA, Holman BL: Detection of intracranial abnormalities in patients with chronic fatigue syndrome: comparison of MR imaging and SPECT. AJR Am J Roentgenol 1994; 162:935-941
51. Schwartz RB, Komaroff AL, Garada BM, Gleit M, Doolittle TH, Bates DW, Vasile RG, Holman BL: SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression. AJR Am J Roentgenol 1994; 162:943-951
52. Cope H, David AS: Neuroimaging in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 1996; 60:471-473
53. Cope H, Pernet A, Kendall B: Cognitive functioning and magnetic resonance imaging in chronic fatigue. Br J Psychiatry 1995; 176:86-94
54. Ichise M, Salit IE, Abbey SE, Chung DG, Gray B, Kirsh JC, Freedman M: Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome. Nucl Med Commun 1992; 13:767-772
55. Lewis D, Mayberg H, Fischer M, Goldberg J, Ashton S, Graham MM, Buchwald D: Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT. Radiology 2001; 219:766-773
56. Komaroff AL: Clinical presentation and evaluation of fatigue and chronic fatigue syndrome, in Chronic Fatigue Syndrome. Edited by Straus SE. New York, Marcel Dekker, 1994, pp 61-84
57. Altay HT, Abbey SE, Toner BR, Salit IE, Brooker H, Garfinkel PE: The neuropsychotogical dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report. Int J Psychiatry Med 1990; 20:141-149
58. DeLuca J, Johnson SK, Beldowicz D, Natelson BH: Neuropsychological impairments in chronic fatigue syndrome, multiple sclerosis, and depression. J Neurol Neurosurg Psychiatry 1995; 58:38-43
59. Michiels V, Cluydts R: Neuropsychological functioning in chronic fatigue syndrome: a review. Acta Psychiatr Scand 2001; 103:84-93
60. Moss-Morris R, Petrie KJ, Large RG, Kydd RR: Neuropsychological deficits in chronic fatigue syndrome: artifact or reality? J Neurol Neurosurg Psychiatry 1996; 60:474-477
61. Tiersky LA, Johnson SK, Lange G, Natelson BH, DeLuca J: Neuropsychology of chronic fatigue syndrome: a critical review. J Clin Exp Neuropsychol 1997; 19:560-586
62. Parker AJR, Wessely S, Cleare AJ: The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med 2001; 31:1331-1345
63. Scott LV, Svec F, Dinan T: A preliminary study of dehydroepiandrosterone response to low-dose ACTH in chronic fatigue syndrome and in healthy subjects. Psychiatry Res 2000; 97:21-28
64. Demitrack MA, Dale JK, Straus SE, Laue L, Listwak SJ, Kruesi MJ, Chrousos GP, Gold PW: Evidence for impaired activation of the hypothalamic-pituitary- adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 1991; 73:1224-1234
65. Demitrack MA: Neuroendocrine correlates of chronic fatigue syndrome: a brief review. J Psychiatr Res 1997; 31:69-82
66. Torpy DJ, Bachmann AW, Grice JE, Fitzgerald SP, Phillips PJ, Whitworth JA, Jackson RV: Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J Clin Endocrinol Metab 2001; 86:3692-3700
67. Cleare AJ, Bearn J, Allain T, McGregor A, Wessely S, Murray RM, O'Keane V: Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. J Affect Disord 1995; 35:283-289
68. O'Keane V, Dinan TG: Prolactin and cortisol responses to d-fenfluramine in major depression: evidence for diminished responsivity of central serotonergic function. Am J Psychiatry 1991; 148:1009-1015
69. Rowe PC, Bou-Holaigah I, Kan JS, Calkins H: Is neurally mediated hypotension an unrecognized cause of chronic fatigue? Lancet 1995; 345:623-624
70. Bou-Holaigah I, Rowe PC, Kan J, Calkins H: The relationship between neurally mediated hypotension and the chronic fatigue syndrome. JAMA 1995; 274:961-967
71. Freeman R, Komaroff AL: Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med 1997; 102:357-364
72. Soetekouw PMMB, Lenders JWM, Bleijenberg G, Thien T, van der Meer JWM: Autonomic function in patients with chronic fatigue syndrome. Clin Auton Res 1999; 9:334-340
73. Poole J, Herrell R, Ashton S, Goldberg J, Buchwald D: Results of isoproterenol tilt table testing in monozygotic twins discordant for chronic fatigue syndrome. Arch Intern Med 2000; 160:3461-3468
74. Wilke WS, Fouad-Tarazi FM, Cash JM, Calabrese LH: The connection between chronic fatigue syndrome and neurally mediated hypotension. Cleve Clin J Med 1998; 65:261-266
75. Peterson PK, Pheley A, Schroeppel J, Schenck C, Marshall P, Kind A, Haugland JM, Lambrecht LJ, Swan S, Goldsmith S: A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome. Arch Intern Med 1998; 158:908-914
76. Rowe PC, Calkins H, DeBusk K, McKenzie R, Anand R, Sharma G, Cuccherini BA, Soto N, Hohman P, Snader S, Lucas KE, Wolff M, Straus SE: Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial. JAMA 2001; 285:52-59
77. Klimas NG, Salvato FR, Morgan R, Fletcher MA: Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol 1990; 28:1403-1410
78. Straus SE, Fritz S, Dale JK, Gould B, Strober W: Lymphocyte phenotype and function in the chronic fatigue syndrome. J Clin Immunol 1993; 13:30-40
79. Landay AL, Jessop C, Lennette ET, Levy JA: Chronic fatigue syndrome: clinical condition associated with immune activation. Lancet 1991; 338:707-712
80. Caligiuri M, Murray C, Buchwald D, Levine H, Cheney P, Peterson D, Komaroff AL, Ritz J: Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol 1987; 139:3306-3313
81. Wakiguchi H, Fujieda M, Matsumoto K, Ohara Y, Wakiguchi A, Kurashige T: Defective killer cell activity in patients with chronic active Epstein-Barr virus infection. Acta Med Okayama 1988; 42:137-142
82. Eby NL, Grufferman S, Huang M, Whiteside T, Sumaya C, Saxinger WC: Natural killer cell activity in the chronic fatigue-immune dysfunction syndrome, in Natural Killer Cells and Host Defense. Edited by Ades EW, Lopez C. Basel, Switzerland, Karger, 1989, pp 141-145
83. Morrison LJA, Behan WMH, Behan PO: Changes in natural killer cell phenotype in patients with post-viral fatigue syndrome. Clin Exp Immunol 1991; 83:441-446
84. Barker E, Fujimura SF, Fadem MB, Landay AL, Levy JA: Immunologic abnormalities associated with chronic fatigue syndrome. Clin Infect Dis 1994; 18(suppl 1):S136-S141
85. Konstantinov K, von Mikecz A, Buchwald D, Jones J, Gerace L, Tan EM: Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome. J Clin Invest 1996; 98:1888-1896
86. von Mikecz A, Konstantinov K, Buchwald DS, Gerace L, Tan EM: High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. Arthritis Rheum 1997; 40:295-305
87. Cruess SE, Klimas N, Antoni MH, Helder L, Maher K, Keller R, Fletcher MA: Immunologic status correlates with severity of physical symptoms and perceived illness burden in chronic fatigue syndrome patients. J Chronic Fatigue Syndr 2000; 7:39-52
88. Peakman M, Deale A, Field R, Mahalingam M, Wessely S: Clinical improvement in chronic fatigue syndrome is not associated with lymphocyte subsets of function or activation. Clin Immunol Immunopathol 1997; 82:83-91
89. Strober W: Immunological functioning in chronic fatigue syndrome, in Chronic Fatigue Syndrome. Edited by Straus SE. New York, Marcel Dekker, 1994, pp 207-237
90. Ablashi DV: Viral studies of CFS. Clin Infect Dis 1994; 18(suppl 1):130-132
91. De Meirlier K, Bisbal C, Campine I, De Becker P, Salehzada T, Demettre E, Lebleu BA: 37 kDa 25A binding protein as a potential biochemical marker for chronic fatigue syndrome. Am J Med 2000; 108:99-105
92. Hotopf MH, Wessely S: Viruses, neurosis and fatigue. J Psychosom Res 1994; 38:499-514
93. Farrar DJ, Locke SE, Kantrowitz FG: Chronic fatigue syndrome, 1: etiology and pathogenesis. Behav Med 1995; 21:5-16
94. Straus SE, Dale JK, Tobi M, Lawley T, Preble O, Blaese RM, Hallahan C, Henle W: Acyclovir treatment of the chronic fatigue syndrome: lack of efficacy in a placebo-controlled trial. N Engl J Med 1988; 319:1692-1698
95. Wilson A, Hickie I, Lloyd A, Wakefield D: The treatment of chronic fatigue syndrome: science and speculation. Am J Med 1994; 96:544-550
96. Morriss R, Sharpe M, Sharpley A, Cowen PJ, Hawton K, Morris J: Abnormalities of sleep in patients with chronic fatigue syndrome. Br Med J 1993; 306:1161-1164
97. Sharpley A, Clements A, Hawton K, Sharpe M: Do patients with "pure" chronic fatigue syndrome (neurasthenia) have abnormal sleep? Psychosom Med 1997; 59:592-596
98. Krupp LB, Jandorf L, Coyle PK, Mendelson WB: Sleep disturbance in chronic fatigue syndrome. J Psychosom Res 1993; 37:325-331
99. Whelton CL, Salit I, Moldofsky H: Sleep, Epstein-Barr virus infection, musculoskeletal pain, and depressive symptoms in chronic fatigue syndrome. J Rheumatol 1992; 19:939-943
100. Fischler B, LeBon O, Hoffman G, Cluydts R, Kaufman L, DeMeirleir K: Sleep anomalies in the chronic fatigue syndrome - a comorbidity study. Neuropsychobiology 1997; 35:115-122
101. Manu P, Lane TJ, Matthews DA, Castriotta RJ, Watson RK, Abeles M: Alpha-delta sleep patterns in patients with chief complaint of chronic fatigue. South Med J 1994; 87:1289-1290
102. Gillin JC, Sitaram N, Wehr T: Sleep and affective illness, in Neurobiology of Mood Disorder. Edited by Post RM, Ballenger JC. Baltimore, Williams &Wilkins, 1984, pp 157-189
103. Buchwald D, Pascualy R, Bombardier C, Kith P: Sleep disorders in patients with chronic fatigue. Clin Infect Dis 1994; 18(suppl 1):S68-S72
104. Vercoulen JH, Hommes OR, Swanink CM, Jongen PJ, Fennis JF, Galama JM, van der Meer JW, Bleijenberg G: The measurement of fatigue in patients with multiple sclerosis: a multidimensional comparison with patients with chronic fatigue syndrome and healthy subjects. Arch Neurol 1996; 53:642-649
105. Vercoulen JHMM, Swanink CMA, Fennis JFM, Galama JM, van der Meer JW, Bleijenberg G: Prognosis in chronic fatigue syndrome: a prospective study of the natural course. J Neurol Neurosurg Psychiatry 1996; 60:489-494
106. Vercoulen JH, Swanink CM, Galama JM, Fennis JF, Jongen PJ, Hommes OR, van der Meer JW, Bleijenberg G: The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model. J Psychosom Res 1998; 45:507-517
107. Van der Werf S, Prins JB, Vercoulen JHMM, van der Meer JWM, Bleijenberg G: Identifying physical activity patterns in chronic fatigue syndrome using actigraphic assessment. J Psychosom Res 2000; 49:373-379
108. White PD: The role of physical inactivity in the chronic fatigue syndrome. J Psychosom Res 2000; 49:283-284
109. Lane RJ, Barret CB, Woodrow D, Moss J, Fletcher R, Archard LC: Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 1998; 64:362-367
110. McCully KK, Natelson BH: Impaired oxygen delivery to muscle in chronic fatigue syndrome. Clin Sci 1999; 97:603-608
111. Wagenmakers AJM, Coakley JH, Edwards RHT: The metabolic consequences of reduced habitual activities in patients with muscle pain and disease. Ergonomics 1988; 31:1519-1527
112. Fischler B, Dendale P, Michiels V, Cluydts R, Kaufman L, De Meirleir K: Physical fatigability and exercise capacity in chronic fatigue syndrome: association with disability, somatization and psychopathology. J Psychosom Res 1997; 42:369-378
113. De Becker P, Roeykens J, Reynders M, McGregor N, De Meirleir K: Exercise capacity in chronic fatigue syndrome. Arch Intern Med 2000; 160:3270-3277
114. Fulcher KY, White PD: Strength and physiological response to exercise in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 2000; 69:302-307
115. Sisto SA, LaManca J, Cordero DL, Bergen MT, Ellis SP, Drastal S, Boda WL, Tapp WN, Natelson BH: Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome. Am J Med 1996; 100:634-640
116. Riley MS, O'Brien CJ, McCluskey DR, Ball NP, Nicholls DP: Aerobic work capacity in patients with chronic fatigue syndrome. Br Med J 1990; 301:953-956
117. Gibson H, Carroll N, Clague JE, Edwards RHT: Exercise performance and fatigability in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 1993; 56:993-998
118. Fry AM, Martin M: Fatigue in the chronic fatigue syndrome: a cognitive phenomenon? J Psychosom Res 1996; 41:415-426
119. Montague TR, Marrie TJ, Klassen GA, Bewick DJ, Horacek BM: Cardiac function at rest and with exercise in the chronic fatigue syndrome. Chest 1989; 95:779-784
120. Bazelmans E, Bleijenberg G, van Der Meer JWM, Folgering H: Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? a controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity. Psychol Med 2001; 31:107-114
121. Manu P, Lane TJ, Matthews DA: Chronic fatigue and chronic fatigue syndrome: clinical epidemiology and aetiological classification, in Chronic Fatigue Syndrome. Edited by Bock GR, Whelan J. Chichester, UK, John Wiley & Sons, 1993, pp 23-42
122. Stewart DE: Emotional disorders misdiagnosed as physical illness: environmental hypersensitivity, candidiasis hypersensitivity, and chronic fatigue syndrome. Int J Ment Health 1990; 19:56-68
123. Shorter E: From Paralysis to Fatigue: A History of Psychosomatic Illness in the Modern Era. New York, Free Press, 1992
124. Manu P, Affleck G, Tennen H, Morse PA, Escobar JI: Hypochondriasis influences quality-of-life outcomes in patients with chronic fatigue syndrome. Psychother Psychosom 1996; 65:76-81
125. Greenberg DB: Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders. Psychosomatics 1990; 31:129-137
126. Manu P, Matthews DA, Lane TJ, Tennen H, Hesselbrock V, Mendola R, Affleck G: The mental health of patients with a chief complaint of chronic fatigue: a prospective evaluation and follow-up. Arch Intern Med 1988; 148:2213-2217
127. Abbey SE, Garfinkle PE: Chronic fatigue syndrome and depression: cause, effect, or covariate. Rev Infect Dis 1991; 18(suppl 1):S73-S83
128. Wessely S, Chalder T, Hirsch S, Wallace P, Wright D: Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting. Am J Psychiatry 1996; 153:1050-1059
129. Katon WJ, Buchwald D, Simon G, Russo JE, Mease PJ: Psychiatric illness in patients with chronic fatigue and those with rheumatoid arthritis. J Gen Intern Med 1991; 6:277-285
130. Wood GC, Bentall RP, Gopfert M, Edwards RHT: A comparative assessment of patients with chronic fatigue syndrome and muscle disease. Psychol Med 1991; 21:618-628
131. Wessely S, Powell R: Fatigue syndromes: a comparison of chronic "postviral" fatigue with neuromuscular and affective disorders. J Neurol Neurosurg Psychiatry 1989; 52:940-948
132. Manu P, Matthews DA, Lane TJ: Depression among patients with a chief complaint of chronic fatigue. J Affect Disord 1989; 17:165-172
133. Fischler B, Cluydts R, DeGucht V, Kaufman L, DeMeirleir K: Generalized anxiety disorder in chronic fatigue syndrome. Acta Psychiatr Scand 1997; 95:405-413
134. Lane TJ, Manu P, Matthews DA: Depression and somatization in the chronic fatigue syndrome. Am J Med 1991; 91:335-344
135. Kruesi MJ, Dale J, Straus SE: Psychiatric diagnoses in patients who have chronic fatigue syndrome. J Clin Psychiatry 1989; 50:53-56; correction, 50:148
136. Hickie I, Lloyd A, Wakefield D, Parker G: The psychiatric status of patients with chronic fatigue syndrome. Br J Psychiatry 1990; 156:534-540
137. Robins LN, Helzer JE, Cottler L, Golding E: National Institute of Mental Health Diagnostic Interview Schedule, version III, revised. St Louis, Washington University, Department of Psychiatry, 1989
138. Spitzer RL, Williams JBW, Gibbon M, First MB: Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1988
139. Taylor R, Jason LA: The effects of psychiatric instrumentation and scoring on psychiatric diagnoses for individuals with CFS. Psychol Health 1998; 13:1087-1104
140. Escobar JL, Burnam A, Karno M, Forsythe A, Golding JM: Somatization in the community. Arch Gen Psychiatry 1987; 44:713-718
141. Johnson SK, DeLuca J, Natelson BH: Assessing somatization disorder in the chronic fatigue syndrome. Psychosom Med 1996; 58:50-57
142. Manu P, Lane TJ, Matthews DA: Somatization disorder in patients with chronic fatigue. Psychosomatics 1989; 30:388-395
143. Pepper CM, Krupp LB, Friedberg F, Doscher C, Coyle PK: A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression. J Neuropsychiatry Clin Neurosci 1993; 5:200-205
144. Johnson SK, DeLuca J, Natelson BH: Chronic fatigue syndrome: reviewing the research findings. Ann Behav Med 1999; 21:258-271
145. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen H-U, Kendler KS: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51:8-19
146. Buchwald DS, Pearlman T, Kith P, Schmaling K: Gender differences in patients with chronic fatigue syndrome. J Gen Intern Med 1994; 9:397-401
147. Nutt DJ: Neurobiological mechanisms in generalized anxiety disorder: discussion. J Clin Psychiatry 2001; 62:22-27
148. Powell R, Dolan R, Wessely S: Attributions and self-esteem in depression and chronic fatigue syndrome. J Psychosom Res 1990; 34:665-673
149. Johnson SK, DeLuca J, Natelson BH: Depression in fatiguing illness: comparing patients with chronic fatigue syndrome, multiple sclerosis, and depression. J Affect Disord 1996; 39:21-30
150. Vercoulen JHMM, Swanink CMA, Zitman FG, Vreden SG, Hoofs MP, Fennis JF, Galama JM, van der Meer JW, Bleijenberg G: Randomized, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. Lancet 1996; 347:858-861
151. Cassem EH: Depression and anxiety secondary to medical illness. Psychiatr Clin North Am 1990; 13:597-612
152. Kendler KS: A psychiatric dialogue on the mind-body problem. Am J Psychiatry 2001; 158:989-1000
153. Graham DT: Health, disease, and the mind-body problem: linguistic parallelism. Psychosom Med 1967; 24:52-71
154. Oken D: Multiaxial diagnosis and the psychosomatic model of disease. Psychosom Med 2000; 62:171-175
155. Sensky T, MacLeod AK, Rigby MF: Causal attributions about common somatic sensations among frequent general practice attenders. Psychol Med 1996; 26:641-646
156. Schweitzer R, Robertson DL, Kelly B, Whiting J: Illness behavior of patients with chronic fatigue syndrome. J Psychosom Res 1993; 38:41-49
157. Butler JA, Chalder T, Wessely S: Causal attributions for somatic sensations in patients with chronic fatigue syndrome and their partners. Psychol Med 2001; 31:97-105
158. Cathebras P, Jacquin L, LeGal M, Fayol C, Bouchou K, Rousset H: Correlates of somatic causal attributions in primary care patients with fatigue. Psychother Psychosom 1995; 63:174-180
159. Sharpe M, Hawton K, Seagrott V, Pasvol G: Follow up of patients presenting with fatigue to an infectious diseases clinic. Br Med J 1992; 305:147-152
160. Chalder T, Power MJ, Wessely S: Chronic fatigue in the community: a question of attribution. Psychol Med 1996; 26:791-800
161. Wilson A, Hickie I, Lloyd A, Hadzi-Pavlovic D, Boughton C, Dwyer J, Wakefield D: Longitudinal study of outcome of chronic fatigue syndrome. Br Med J 1994; 308:756-759
162. Schmaling KB, Smith WR, Buchwald DS: Significant other responses are associated with fatigue and functional status among patients with chronic fatigue syndrome. Psychosom Med 2000; 62:444-450
163. Cioffi D: Beyond attentional strategies: a cognitive-perceptual model of somatic interpretation. Psychol Bull 1991; 109:25-41
164. Moss-Morris R, Petrie KJ: Cognitive distortions of somatic experiences: revision and validation of a measure. J Psychosom Res 1997; 43:293-306
165. Petrie KJ, Booth RJ, Elder H, Cameron LD: Psychological influences on the perception of immune function. Psychol Med 1999; 29:391-397
166. Heijmans MJWM: Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions. J Psychosom Res 1998; 45:39-51
167. Moss-Morris R, Petrie KJ, Weinman J: Functioning in chronic fatigue syndrome: do illness perceptions play a regulatory role? Br J Health Psychol 1996; 1:15-25
168. Schmaling KB, Hamilos DL, DiClementi JD, Jones JF: Pain perception in chronic fatigue syndrome. J Chronic Fatigue Syndr 1998; 4:13-22
169. Maxiner E, Fillingim T, Sigurdsson S, Kincaid D, Silva S: Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain. Pain 1998; 76:71-81
170. Gibson SJ, Granges G, Littlejohn GO, Helme RD: Increased thermal pain sensitivity in patients with fibromyalgia syndrome, in Pain and the Brain: From Nociception to Cognition: Advances in Pain Research and Therapy, vol 22. Edited by Bromm B, Desmedt JE. New York, Raven Press, 1995, pp 401-411
171. Lautenbacher S, Rollman GB, McCain GA: Multi-method assessment of experimental and clinical pain in patients with fibromyalgia. Pain 1994; 59:45-53
172. Blakely AA, Howard RC, Sosich RM, Murdoch JC, Menkes DB, Spears GF: Psychiatric symptoms, personality and ways of coping in chronic fatigue syndrome. Psychol Med 1991; 21:347-362
173. Cope H, Mann A, Pelosi A, David A: Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study. Psychol Med 1996; 26:1197-1209
174. Afari N, Schmaling K, Herrell R, Ashton S, Goldberg J, Buchwald DS: Coping strategies in twins with chronic fatigue and chronic fatigue syndrome. J Psychosom Res 2000; 48:547-554
175. Ray C, Jeffries S, Weir WR: Coping and other predictors of outcome in chronic fatigue syndrome: a 1-year follow-up. J Psychosom Med 1997; 43:405-415
176. Antoni MH, Brickman A, Lutgendorf S, Klimas A, Imia-Fins A, Ironson G, Quillian R, Miguez MJ, van Riel F, Morgan R, Patarca R, Fletcher MA: Psychosocial correlates of illness burden in chronic fatigue syndrome. Clin Infect Dis 1994; 18:S73-S78
177. Lane T, Matthews D, Manu P: The low yield of physical examinations and laboratory investigations of patients with chronic fatigue. Am J Med Sci 1990; 299:313-318
178. Lloyd A, Hickie I, Wakefield D, Boughton C, Dwyer J: A double-blind, placebo-controlled trial of intravenous immunoglobulin therapy in patients with chronic fatigue syndrome. Am J Med 1990; 89:561-568
179. 12U), in chronic fatigue syndrome. Clin Infect Dis 1994; 18 (suppl 1):S88-S95
180. Steinberg P, McNutt BE, Marshall P, Schenck C, Lurie N, Pheley A, Peterson PK: Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome. J Allergy Clin Immunol 1996; 97:119-126
181. Peterson PK, Shepard J, Macres M, Schenck C, Crosson J, Rechtman D, Lurie N: A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome. Am J Med 1990; 89:554-560
182. Vollmer-Conna U, Hickie I, Hadzi-Pavlovic D, Tymms K, Wakefield D, Dwyer J, Lloyd A: Intravenous immunoglobulin is ineffective in the treatment of patients with chronic fatigue syndrome. Am J Med 1997; 103:38-43
183. See DM, Tilles JG: Alpha-interferon treatment of patients with chronic fatigue syndrome. Immunol Invest 1996; 25:153-164
184. Brook MG, Bannister BA, Weir WR: Interferon-alpha therapy for patients with chronic fatigue syndrome. J Infect Dis 1993; 168:791-792
185. De Vinci C, Levine PH, Pizza G, Fundenberg HH, Orens P, Pearson G, Viza D: Lessons from a pilot study of transfer factor in chronic fatigue syndrome. Biotherapy 1996; 9:87-90
186. Andersson M, Bagby JR, Dyrehag LE, Gottfries CG: Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome. Eur J Pain 1998; 2:133-142
187. Lloyd A, Hickie I, Brockman A, Hickie C, Wilson A, Dwyer J, Wakefield D: Immunologic and psychologic therapy for patients with chronic fatigue syndrome: a double-blind, placebo-controlled trial. Am J Med 1993; 94:197-203
188. McKenzie R, O'Fallon A, Dale J, Demitrack M, Sharma G, Deloria M, Garcia Borreguero D, Blackwelder W, Straus SE: Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial. JAMA 1998; 280:1061-1066
189. McKenzie R, Reynolds JC, O'Fallon A, Dale J, Deloria M, Blackwelder W, Straus SE: Decreased bone mineral density during low dose glucocorticoid administration in a randomized, placebo-controlled trial. J Rheumatol 2000; 27:2222-2226
190. Moorkens G, Wynants H, Abs R: Effect of growth hormone treatment in patients with chronic fatigue syndrome: a preliminary study. Growth Horm IGF Res 1998; 8:131-133
191. Snorrason E, Geirsson A, Stefansson K: Trial of a selective acetylcholinesterase inhibitor, galanthamine hydrobromide, in the treatment of chronic fatigue syndrome. J Chronic Fatigue Syndr 1996; 2:35-54
192. Forsyth LM, Preuss HG, MacDowell AL, Chiazze L Jr, Birkmayer GD, Bellanti JA: Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy Asthma Immunol 1999; 82:185-191
193. Natelson BH, Cheu J, Pareja J, Ellis SP, Policastro T, Findley TW: Randomized, double-blind, controlled placebo-phase trial of low dose phenelzine in the chronic fatigue syndrome. Psychopharmacology (Berl) 1996; 124:226-230
194. Hickie IB, Wilson AJ, Wright JM, Bennett BK, Wakefield D, Lloyd AR: A randomized, double-blind placebo-controlled trial of moclobemide in patients with chronic fatigue syndrome. J Clin Psychiatry 2000; 61:643-648
195. Cleare AJ, Heap E, Malhi GS, Wessely S, O'Keane V, Miell J: Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Lancet 1999; 353:455-458
196. Natelson BH, Cheu J, Hill N, Bergen M, Korn L, Denny T, Dahl K: Single-blind, placebo phase-in trial of two escalating doses of selegiline in the chronic fatigue syndrome. Neuropsychobiology 1998; 37:150-154
197. Wearden AJ, Morriss RK, Mullis R, Strickland PL, Pearson DJ, Appleby L, Campbell IT, Morris JA: Randomised, double-blind, placebo-controlled treatment trial of fluoxetine and graded exercise for chronic fatigue syndrome. Br J Psychiatry 1998; 172:485-490; correction, 173:89
198. Fulcher KY, White PD: Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome. Br Med J 1997; 314:1647-1652
199. Powell P, Bentall RP, Nye FJ, Edwards RHT: Randomised controlled trial of patient education to encourage graded exercise in chronic fatigue syndrome. Br Med J 2001; 322:1-5
200. Field TM, Sunshine W, Hernandez-Reif M, Quintino O, Schanberg S, Kuhn C, Burman I: Massage therapy effects on depression and somatic symptoms in chronic fatigue syndrome. J Chronic Fatigue Syndr 1997; 3:43-51
201. Perrin RN, Edwards J, Hartley P: An evaluation of the effectiveness of osteopathic treatment on symptoms associated with myalgic encephalomyelitis: a preliminary report. J Med Eng Technol 1998; 22:1-13
202. Friedberg F, Krupp LB: A comparison of cognitive behavioral treatment for chronic fatigue syndrome and primary depression. Clin Infect Dis 1994; 18(suppl 1):S105-S110
203. Deale A, Chalder T, Marks I, Wessely S: Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled trial. Am J Psychiatry 1997; 154:408-414
204. Deale A, Chalder T, Wessely S: Illness beliefs and treatment outcome in chronic fatigue syndrome. J Psychosom Res 1998; 45:77-83
205. Sharpe M, Hawton K, Simkin S, Surawy C, Hackmann A, Klimes I, Peto T, Warrell D, Seagroatt V: Cognitive behaviour therapy for the chronic fatigue syndrome: a randomised controlled trial. Br Med J 1996; 312:22-26
206. Sharpe M, Hawton K, Simkin S, Surawy C, Hackmann A, Klimes I, Peto T, Warrell D, Seagroatt V: Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled study. Verhaltenstherapie 1998; 8:118-124
207. Chisholm D, Godfrey E, Ridsdale L, Chalder T, King M, Seed P, Wallace P, Wessely S (Fatigue Trialists' Group): Chronic fatigue in general practice: economic evaluation of counseling versus cognitive behaviour therapy. Br J Gen Pract 2001; 51:15-18
208. Ridsdale L, Godfrey E, Chalder T, Seed P, King M, Wallace P, Wessely S: Chronic fatigue in general practice: is counselling as good as cognitive behaviour therapy? Br J Gen Pract 2001; 51:19-24
209. Prins JB, Bleijenberg G, Bazelmans E, Elving LD, de Boo TM, Severens JL, van der Wilt GJ, Spinhoven P, van der Meer JW: Cognitive behaviour therapy for chronic fatigue syndrome: a multicenter randomised controlled trial. Lancet 2001; 357:841-847
210. Shlaes JL, Jason LA: A buddy/mentor program for PWCs. CFIDS Chronicle, winter 1996, pp 21-25
211. Marlin RG, Anchel H, Gibson JC, Goldberg WM, Swinton M: An evaluation of multidisciplinary intervention for chronic fatigue syndrome with long-term follow-up, and a comparison with untreated controls. Am J Med 1998; 105:1105-1145
212. Cox IM, Campbell MJ, Dowson D: Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991; 337:757-760
213. Warren G, McKendrick M, Peet M: The role of essential fatty acids in chronic fatigue syndrome: a case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand 1999; 99:112-116
214. Kaslow JE, Rucker L, Onishi R: Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989; 149:2501-2503
215. Awdry R: Homeopathy may help ME. Int J Altern Complement Med 1996; 14:12-16
216. Awdry R: Homoeopathy and chronic fatigue: the search for proof. Int J Altern Complement Med 1996; 14:19-20
217. Whiting P, Bagnall AM, Sowden AJ, Cornell JE, Mulrow CD, Ramirez G: Interventions for the treatment and management of chronic fatigue syndrome: a systematic review. JAMA 2001; 286:1360-1368
218. White PD, Cleary KJ: An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome. Int Clin Psychopharmacol 1997; 12:47-52
219. Arnold LM, Keck PE Jr, Welge JA: Antidepressant treatment of fibromyalgia: a meta-analysis and review. Psychosomatics 2000; 41:104-113
220. Surawy C, Hackman A, Hawton K, Sharpe M: Chronic fatigue syndrome: a cognitive approach. Behav Res Ther 1995; 33:534-544
221. Wearden A, Morriss R, Mullis R: A double-blind placebo-controlled trial of fluoxetine and graded exercise for chronic fatigue syndrome (abstract). Eur Psychiatry 1996; 11(suppl 4):273
222. Deale A, Husain K, Chalder T, Wessely S: Long-term outcome of cognitive behavior therapy versus relaxation therapy for chronic fatigue syndrome: a 5-year follow-up study. Am J Psychiatry 2001; 158:2038-2042
223. Afari N, Eisenberg D, Herrell R, Goldberg J, Kleyman E, Ashton S, Buchwald DS: Use of alternative treatments by chronic fatigue syndrome discordant twins. Integr Med 2000; 2:97-103
224. Behan PO, Behan WM, Horrobin D: Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand 1990; 82:209-216
225. Martin RWY, Ogston SA, Evans JR: Effects of vitamin and mineral supplementation on symptoms associated with chronic fatigue syndrome with coxsackie B antibodies. J Nutr Med 1994; 4:11-23
226. Reid S, Chalder T, Cleare A, Hotopf M, Wessely S: Chronic fatigue syndrome. Br Med J 2000; 320:292-296
227. Kisely SR: Treatments for chronic fatigue syndrome and the Internet: a systematic survey of what your patients are reading. Australian NZ J Psychiatry 2002; 36:240-245
228. Bonner D, Ron M, Chalder T, Butler S, Wessely S: Chronic fatigue syndrome: a follow-up study. J Neurol Neurosurg Psychiatry 1994; 57:617-621
229. Joyce J, Hotopf M, Wessely S: The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review. Q J Med 1997; 90:223-233
230. Krilov LR, Fisher M, Friedman SB, Reitman D, Mandel FS: Course and outcome of chronic fatigue in children and adolescents. Pediatrics 1998; 102:360-366