Controlled and Extended Release of a Model Protein from a Microsphere-Hydrogel Drug Delivery System

Annals of Biomedical Engineering

Volumn 43, Issue 11, 2015, Pages 2609-2617

  Osswald, Christian R ^a   Kang Mieler, Jennifer J ^a  

^a Illinois Institute of Technology   (United States)

Author keywords

Hydrogel; Microspheres; Ocular drug delivery; Ovalbumin; Poly(lactic co glycolic acid); Poly(N isopropylacrylamide)

Indexed keywords

ACRYLIC MONOMERS; AMIDES; COPOLYMERS; DRUG DELIVERY; HYDROGELS; MICROSPHERES; PROTEINS;

DESIGN CONSIDERATIONS; DRUG DELIVERY SYSTEM; FABRICATION TECHNIQUE; OCULAR DRUG DELIVERY; OVALBUMINS; POLY (N ISOPROPYLACRYLAMIDE); POLY LACTIC-CO-GLYCOLIC ACID; RELEASE CHARACTERISTICS;

CONTROLLED DRUG DELIVERY;

IODINE 125; MICROSPHERE; OVALBUMIN; POLY(N ISOPROPYLACRYLAMIDE); POLYGLACTIN; ACRYLIC ACID RESIN; DELAYED RELEASE FORMULATION; HYDROGEL; LACTIC ACID; MACROGOL DERIVATIVE; POLY-N-ISOPROPYLACRYLAMIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; HYDROGEL; INTRAOCULAR DRUG ADMINISTRATION; ISOTOPE LABELING; POSTERIOR EYE SEGMENT; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; SUSTAINED RELEASE FORMULATION; TIME; ADMINISTRATION AND DOSAGE; CHEMISTRY; DELAYED RELEASE FORMULATION;

ACRYLIC RESINS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HYDROGELS; LACTIC ACID; MICROSPHERES; OVALBUMIN; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID;

EID: 84945482901     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-015-1314-7     Document Type: Article

References (24)

1. Allison, S. D. Analysis of initial burst in PLGA microparticles. Expert Opin. Drug Deliv. 5:615–628, 2008.
2. Alonso, M. J., S. Cohen, T. G. Park, R. K. Gupta, G. R. Siber, and R. Langer. Determinants of release rate of tetanus vaccine from polyester microspheres. Pharm. Res. 10:945–953, 1993.
3. Blanco, D., and M. J. Alonso. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur. J. Pharm. Biopharm. 45:285–294, 1998.
4. Crotts, G., and T. G. Park. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues. J. Microencapsul. 15:699–713, 1998.
5. Cutright, D. E., B. Perez, J. D. Beasley, III, W. J. Larson, and W. R. Posey. Degradation rates of polymers and copolymers of polylactic and polyglycolic acids. Oral Surg. Oral Med. Oral Pathol. 37:142–152, 1974.
6. Derwent, J. J. K., and W. F. Mieler. Thermoresponsive hydrogels as a new ocular drug delivery platform to the posterior segment of the eye. Trans. Am. Ophthalmol. Soc. 106:206–214, 2008.
7. Drapala, P. W., E. M. Brey, W. F. Mieler, D. C. Venerus, J. J. KangDerwent, and V. H. Pérez-Luna. Role of thermo-responsiveness and poly(ethylene glycol) diacrylate cross-link density on protein release from poly(N-isopropylacrylamide) hydrogels. J. Biomater. Sci. Polym. E 22:59–75, 2010.
8. Drapala, P. W., B. Jiang, Y.-C. Chiu, W. F. Mieler, E. M. Brey, J. J. Kang-Mieler, and V. H. Pérez-Luna. The effect of glutathione as chain transfer agent in PNIPAAm-based thermo-responsive hydrogels for controlled release of proteins. Pharm. Res. 31:742–753, 2014.
9. Freiberg, S., and X. X. Zhu. Polymer microspheres for controlled drug release. Int. J. Pharm. 282:1–18, 2004.
10. Giteau, A., M. C. Venier-Julienne, A. Aubert-Pouëssel, and J. P. Benoit. How to achieve sustained and complete protein release from PLGA-based microparticles? Int. J. Pharm. 350:14–26, 2008.
11. Herrero-Vanrell, R., I. Bravo-Osuna, V. Andrés-Guerrero, M. Vicario-de-la-Torre, and I. T. Molina-Martínez. The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies. Prog. Retin. Eye Res. 42:27–43, 2014.
12. Jeffery, H., S. S. Davis, and D. T. O’Hagan. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharm. Res. 10:362–368, 1993.
13. Jiang, B., G. Zhang, and E. M. Brey. Dual delivery of chlorhexidine and platelet-derived growth factor-BB for enhanced wound healing and infection control. Acta Biomater. 9:4976–4984, 2013.
14. Kang-Mieler, J. J., C. R. Osswald, and W. F. Mieler. Advances in ocular drug delivery: emphasis on the posterior segment. Expert Opin. Drug Deliv. 11:1647–1660, 2014.
15. Kim, H. K., and T. G. Park. Microencapsulation of dissociable human growth hormone aggregates within poly(d, l-lactic-co-glycolic acid) microparticles for sustained release. Int. J. Pharm. 229:107–116, 2001.
16. Lam, X. M., E. T. Duenas, A. L. Daugherty, N. Levin, and C. Jeffrey. Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. J. Control Release 67:281–292, 2000.
17. Manning, M. C., D. K. Chou, B. M. Murphy, R. W. Payne, and D. S. Katayama. Stability of protein pharmaceuticals: an update. Pharm. Res. 27:544–575, 2010.
18. Maurice, D. Review: practical issues in intravitreal drug delivery. J. Ocul. Pharmacol. Ther. 17:393–401, 2001.
19. Osswald, C. R. and J. J. Kang-Mieler. Extended release of ovalbumin as a model for ranibizumab in an ocular drug delivery system, in Advances in Drug Delivery to the Eye. J. Controll. Release Controlled Release Society Annual Meeting, 2014.
20. Peyman, G. A., E. M. Lad, and D. M. Moshfeghi. intravitreal injection of therapeutic agents. Retina 29:875–912, 2009.
21. Van de Weert, M., W. E. Hennink, and W. Jiskoot. Protein instability in poly (lactic-co-glycolic acid) microparticles. Pharm. Res. 17:1159–1167, 2000.
22. Xu, L., T. Lu, L. Tuomi, N. Jumbe, J. Lu, S. Eppler, P. Kuebler, L. A. Damico-Beyer, and A. Joshi. Pharmacokinetics of ranibizumab in patients with neovascular age-related macular degeneration: a population approach. Investig. Ophthalmol. Vis. Sci. 54:1616–1624, 2013.
23. Yang, J., and J. L. Cleland. Factors affecting the in vitro release of recombinant human interferon-γ (rhIFN-γ) from PLGA microspheres. J. Pharm. Sci. 86:908–914, 1997.
24. Yeo, Y., and K. Park. Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch. Pharm. Res. 27:1–12, 2004.