The effect of glutathione as chain transfer agent in PNIPAAm-based thermo-responsive hydrogels for controlled release of proteins

Pharmaceutical Research

Volumn 31, Issue 3, 2014, Pages 742-753

  Drapala, Pawel W ^a   Jiang, Bin ^a   Chiu, Yu Chieh ^a   Mieler, William F ^c   Brey, Eric M ^a,b   Kang Mieler, Jennifer J ^a   Pérez Luna, Victor H ^a  

^a Illinois Institute of Technology   (United States)

^b HINES VA HOSPITAL   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

chain transfer agent; controlled release; immunoglobulin G; PEGylation; thermo responsive hydrogels

Indexed keywords

BEVACIZUMAB; BUFFER; FREE RADICAL; GLUTATHIONE; IMMUNOGLOBULIN G; MACROGOL; POLY(N ISOPROPYLACRYLAMIDE); POLYLACTIC ACID; RANIBIZUMAB; RECOMBINANT PROTEIN; VASCULOTROPIN 165;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENCAPSULATION; HUMAN; HUMAN CELL; HYDROGEL; MINIMALLY INVASIVE PROCEDURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN POLYMERIZATION; PROTEIN SECRETION; SOLUBILIZATION; TRANSITION TEMPERATURE; UMBILICAL VEIN ENDOTHELIAL CELL;

ACRYLIC RESINS; ANIMALS; CATTLE; DELAYED-ACTION PREPARATIONS; GLUTATHIONE; HYDROGELS; IMMUNOGLOBULIN G; LACTATES; POLYETHYLENE GLYCOLS; TEMPERATURE; TRANSITION TEMPERATURE;

EID: 84895466689     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1195-0     Document Type: Article

References (36)

1. Linand CC, Anseth KS. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res. 2009;26:631-43.
2. Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K. The development of microgels/nanogels for drug delivery applications. Prog Polym Sci. 2008;33:448-77.
3. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27-46.
4. Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater. 2006;18:1345-60.
5. Sawhney AS, Pathak CP, Hubbell JA. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(alpha-hydroxy acid) diacrylate macromers. Macromolecules. 1993;26:581-7.
6. Westand JL, Hubbell JA. Photopolymerized hydrogel materials for drug-delivery applications. React Polym. 1995;25:139-47.
7. Kloudaand L, Mikos AG. Thermo-responsive hydrogels in biomedical applications. Eur J Pharm Biopharm. 2008;68:34-45.
8. Ruel-Gariepyand E, Leroux JC. In situ-forming hydrogels - review of temperature-sensitive systems. Eur J Pharm Biopharm. 2004;58:409-26.
9. Jeong B, Kim SW, Bae YH. Thermosensitive sol-gel reversible hydrogels. Adv Drug Deliv Rev. 2002;54:37-51.
10. Hoffman AS. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Control Release. 1987;6:297-305.
11. Donati G. Emerging therapies for neovascular age-related macular degeneration: state of the art. Ophthalmologica. 2007;221:366-77.
12. Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ, et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007;143:566-83.
13. Rosenfeld PJ. Intravitreal Avastin: the low cost alternative to lucentis? Am J Ophthalmol. 2006;142:141-3.
14. Bhatnagar P, Spaide Richard F, Takahashi Beatriz S, Peragallo Jason H, Freund KB, Klancnik James Jr M, et al. Ranibizumab for treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina. 2007;27:846-50.
15. Turturro SB, Guthrie MJ, Appel AA, Drapala PW, Brey EM, Pérez-Luna VH, et al. The effects of cross-linked thermo-responsive PNIPAAm-based hydrogel injection on retinal function. Biomaterials. 2011;32:3620-6.
16. Mari M, Morales A, Colell A, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009;11:2685-700.
17. Bertrand N, Fleischer JG, Wasan KM, Leroux J-C. Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes. Biomaterials. 2009;30:2598-605.
18. Chiu Y-C, Larson JC, Perez-Luna VH, Brey EM. Formation of microchannels in poly(ethylene glycol) hydrogels by selective degradation of patterned microstructures. Chem Mater. 2009;21:1677-82.
19. Drapala PW, Brey EM, Mieler WF, Venerus DC, Derwent JJK, Pérez-Luna VH. Role of thermo-responsiveness and poly(ethylene glycol) diacrylate cross-link density on protein release from poly(N- isopropylacrylamide) hydrogels. J Biomater Sci Polym Ed. 2011;22:59-75.
20. Schild HG. Poly (N-isopropylacrylamide) - experiment, theory and application. Prog Polym Sci. 1992;17:163-249.
21. Kaneko Y, Nakamura S, Sakai K, Aoyagi T, Kikuchi A, Sakurai Y, et al. Rapid deswelling response of poly(N-isopropylacrylamide) hydrogels by the formation of water release channels using poly(ethylene oxide) graft chains. Macromolecules. 1998;31:6099-105.
22. Costa R, Carneiro A, Rocha A, Pirraco A, Falcao M, Vasques L, et al. Bevacizumab and ranibizumab on microvascular endothelial cells: a comparative study. J Cell Biochem. 2009;108:1410-7.
23. Klettnerand A, Roider J. Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways. Investig Ophthalmol Vis Sci. 2008;49:4523-7.
24. Kricheldorf HR, Nuyken O, Swift G. Handbook of polymer synthesis. New York: Marcel Dekker; 2005.
25. Flory PJ. Principles of polymer chemistry. Ithaca: Cornell University Press; 1953.
26. Mason MN, Metters AT, Bowman CN, Anseth KS. Predicting controlled-release behavior of degradable PLA-b-PEG-b-PLA hydrogels. Macromolecules. 2001;34:4630-5.
27. Linand CC, Metters AT. Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58:1379-408.
28. Nolan CM, Reyes CD, Debord JD, Garcia AJ, Lyon LA. Phase transition behavior, protein adsorption, and cell adhesion resistance of poly(ethylene glycol) cross-linked microgel particles. Biomacromolecules. 2005;6:2032-9.
29. Furyk S, Zhang YJ, Ortiz-Acosta D, Cremer PS, Bergbreiter DE. Effects of end group polarity and molecular weight on the lower critical solution temperature of poly(N-isopropylacrylamide). J Polym Sci A Polym Chem. 2006;44:1492-501.
30. Friedman M. Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem. 2003;51:4504-26.
31. Williams CG, Malik AN, Kim TK, Manson PN, Elisseeff JH. Variable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulation. Biomaterials. 2005;26:1211-8.
32. Yamaoka T, Tabata Y, Ikada Y. Distribution and tissue uptake of poly(ethylene glycol) with different molecular-weights after intravenous administration to mice. J Pharm Sci. 1994;83:601-6.
33. Metters AT, Anseth KS, Bowman CN. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks: incorporating network non-idealities. J Phys Chem B. 2001;105:8069-76.
34. Metters AT, Anseth KS, Bowman CN. Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel. Polymer. 2000;41:3993-4004.
35. Metters AT, Bowman CN, Anseth KS. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks. J Phys Chem B. 2000;104:7043-9.
36. Fipulaand D, Zhao H. Releasable PEGylation of proteins with customized linkers. Adv Drug Deliv Rev. 2008;60:29-49.