Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51

Cancer Biology and Therapy

Volumn 16, Issue 10, 2015, Pages 1548-1556

  Wang, Bingliang ^a   Hou, Dong ^a   Liu, Qiao ^a   Wu, Tingting ^a   Guo, Haiyang ^a   Zhang, Xiyu ^a   Zou, Yongxin ^a   Liu, Zhaojian ^b   Liu, Jinsong ^c   Wei, Jianjun ^d   Gong, Yaoqin ^a   Shao, Changshun ^a,e  

^a Shandong Key Laboratory of Digital Human and Clinical Anatomy   (China)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e Life Sciences Building Rutgers University   (United States)

Author keywords

artesunate; chemosensitization; homologous recombination repair; ovarian cancer; RAD51

Indexed keywords

ARTESUNATE; CISPLATIN; RAD51 PROTEIN; ARTEMISININ DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOSENSITIVITY; CLONOGENESIS; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARIAN CANCER CELL LINE; OVARY CANCER; OXIDATIVE STRESS; RECOMBINATION REPAIR; ANIMAL; GENETICS; NUDE MOUSE; OVARIAN NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ARTEMISININS; CELL LINE, TUMOR; CISPLATIN; DOWN-REGULATION; FEMALE; HUMANS; MICE; MICE, NUDE; OVARIAN NEOPLASMS; RAD51 RECOMBINASE; REACTIVE OXYGEN SPECIES;

EID: 84945465791     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.1080/15384047.2015.1071738     Document Type: Article

References (24)

1. V.Kulasingam, M.P.Pavlou, E.P.Diamandis. Integrating high-throughput technologies in the quest for effective biomarkers for ovarian cancer. Nat Rev Cancer 2010; 10:371-8; PMID:20383179; http://dx.doi.org/10.1038/nrc2831
2. S.A.Cannistra. Cancer of the ovary. N Engl J Med 2004; 351:2519-2529; PMID:15590954; http://dx.doi.org/10.1056/NEJMra041842
3. T.Efferth, A.Sauerbrey, A.Olbrich, E.Gebhart, P.Rauch, H.O.Weber, J.G.Hengstler, M.E.Halatsch, M.Volm, K.D.Tew, et al. Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol 2003; 64:382-94; PMID:12869643
4. J.Hou, D.Wang, R.Zhang, H.Wang. Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 2008; 14:5519-30; PMID:18765544; http://dx.doi.org/10.1158/1078-0432.CCR-08-0197
5. P.C.Li, E.Lam, W.P.Roos, M.Z.Zdzienicka, B.Kaina, T.Efferth. Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res 2008; 68:4347-51; PMID:18519695; http://dx.doi.org/10.1158/0008-5472.CAN-07-2970
6. N.Berdelle, T.Nikolova, S.Quiros, T.Efferth, B.Kaina. Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATMATR damage response in cancer cells. Mol Cancer Ther 2011; 10:2224-33; PMID:21998290; http://dx.doi.org/10.1158/1535-7163.MCT-11-0534
7. A.M.Lisewski, J.P.Quiros, C.L.Ng, A.K.Adikesavan, K.Miura, N.Putluri, R.T.Eastman, D.Scanfeld, S.J.Regenbogen, L.Altenhofen, et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell 2014; 158:916-28; PMID:25126794; http://dx.doi.org/10.1016/j.cell.2014.07.011
8. W.H.Hsu, Y.S.Hsieh, H.C.Kuo, C.Y.Teng, H.I.Huang, C.J.Wang, S.F.Yang, Y.S.Liou, W.H.Kuo. Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNKp38 MAPK and FasL. Arch Toxicol 2007; 81:719-28; PMID:17673978; http://dx.doi.org/10.1007/s00204-006-0169-y
9. S.M.Meeran, S.Katiyar, S.K.Katiyar. Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicol Appl Pharmacol 2008; 229:33-43; PMID:18275980; http://dx.doi.org/10.1016/j.taap.2007.12.027
10. Z.Liu, Q.Liu, B.Xu, J.Wu, C.Guo, F.Zhu, Q.Yang, G.Gao, Y.Gong, C.Shao. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res 2009; 662:75-83; PMID:19159633; http://dx.doi.org/10.1016/j.mrfmmm.2008.12.009
11. Y.Wang, Q.Liu, Z.Liu, B.Li, Z.Sun, H.Zhou, X.Zhang, Y.Gong, C.Shao. Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. Mutat Res 2012; 734:20-9; PMID:22561209; http://dx.doi.org/10.1016/j.mrfmmm.2012.04.005
12. Q.Liu, H.Jiang, Z.Liu, Y.Wang, M.Zhao, C.Hao, S.Feng, H.Guo, B.Xu, Q.Yang, et al. Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51. PLoS ONE 2011; 6:e23427; PMID:21858113; http://dx.doi.org/10.1371/journal.pone.0023427
13. Z.Mao, A.Seluanov, Y.Jiang, V.Gorbunova. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci USA 2007; 104:13068-73; PMID:17670947; http://dx.doi.org/10.1073/pnas.0702410104
14. S.Reichert, V.Reinboldt, S.Hehlgans, T.Efferth, C.Rödel, F.Rödel. A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin. Radiother Oncol 2012; 103:394-401; PMID:22560712; http://dx.doi.org/10.1016/j.radonc.2012.03.018
15. J.Luo, W.Zhu, Y.Tang, H.Cao, Y.Zhou, R.Ji, X.Zhou, Z.Lu, H.Yang, S.Zhang, et al. Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo. Radiat Oncol 2014; 9:84; PMID:24666614; http://dx.doi.org/10.1186/1748-717X-9-84
16. H.L.Klein. The consequences of Rad51 overexpression for normal and tumor cells. DNA Repair (Amst) 2008; 7:686-93; PMID:18243065; http://dx.doi.org/10.1016/j.dnarep.2007.12.008
17. C.S.Sørensen, L.T.Hansen, J.Dziegielewski, R.G.Syljuåsen, C.Lundin, J.Bartek, T.Helleday. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 2005; 7:195-201; PMID:15665856
18. D.Schild, C.Wiese. Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability. Nucleic Acids Res 2010; 38:1061-70; PMID:19942681; http://dx.doi.org/10.1093/nar/gkp1063
19. E.D.Tichy, R.Pillai, L.Deng, J.A.Tischfield, P.Hexley, G.F.Babcock, P.J.Stambrook. The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels. Stem Cell Res 2012; 9:124-34; PMID:22705496; http://dx.doi.org/10.1016/j.scr.2012.05.004
20. J.Simandlova, J.Zagelbaum, M.J.Payne, W.K.Chu, I.Shevelev, K.Hanada, S.Chatterjee, D.A.Reid, Y.Liu, P.Janscak, et al. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. J Biol Chem 2013; 288:34168-80; PMID:24108124; http://dx.doi.org/10.1074/jbc.M113.484493
21. N.Wei, Y.Shi, L.N.Truong, K.M.Fisch, T.Xu, E.Gardiner, G.Fu, Y.S.Hsu, S.Kishi, A.I.Su, et al. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Mol Cell 2014; 56:323-32; PMID:25284223; http://dx.doi.org/10.1016/j.molcel.2014.09.006
22. J.W.Huang, Y.Wang, K.K.Dhillon, P.Calses, E.Villegas, P.S.Mitchell, M.Tewari, C.J.Kemp, T.Taniguchi. Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity. Mol Cancer Res. 2013; 11:1564-73; PMID:24088786
23. W.Shan, I.Mercado-Uribe, J.Zhang, D.Rosen, S.Zhang, J.Wei, J.Liu. Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. Cell Cycle 2012; 11:2107-13; PMID:22592533; http://dx.doi.org/10.4161/cc.20544
24. H.Guo, Z.Liu, B.Xu, H.Hu, Z.Wei, Q.Liu, X.Zhang, X.Ding, Y.Wang, M.Zhao, et al. Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage. Aging Cell 2013; 12:1110-21; PMID:23869868; http://dx.doi.org/10.1111/acel.12138