The structural integrity of TDP-43 N-terminus is required for efficient aggregate entrapment and consequent loss of protein function

Prion

Volumn 9, Issue 1, 2015, Pages 1-9

  Romano, Valentina ^a   Quadri, Zainuddin ^a   Baralle, Francisco E ^a   Buratti, Emanuele ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

ALS; Post translational modifications; Prion; Protein aggregation; TDP 43

Indexed keywords

MESSENGER RNA; MYC PROTEIN; PROTEIN AGGREGATE; TAR DNA BINDING PROTEIN; TETRACYCLINE; DNA BINDING PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN METABOLISM; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FRONTOTEMPORAL DEMENTIA; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; PRION; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION; UBIQUITINATION; WESTERN BLOTTING; BIOLOGICAL MODEL; CHEMISTRY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; PROTEINOSIS; STRUCTURE ACTIVITY RELATION;

DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITINATION;

EID: 84945448556     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.1080/19336896.2015.1011885     Document Type: Article

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