Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors

Journal of Medicinal Chemistry

Volumn 58, Issue 20, 2015, Pages 7972-7990

  Li, Wenming ^a   Niu, Youhong ^a,b   Xiong, De Cai ^a   Cao, Xiaoping ^b   Ye, Xin Shan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPENTANE; GLYCOSYLTRANSFERASE INHIBITOR; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDOUS ACID DERIVATIVE; SIALYLTRANSFERASE INHIBITOR; TRISODIUM CYTIDIN 5' YL(3 BENZYLOXY 4 ACETAMIDO 1 CYCLOPENTYLPHOSPHONATOMETHYL)PHOSPHAT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BETA-D-GALACTOSIDE ALPHA 2-6-SIALYLTRANSFERASE; CYCLOPENTANE DERIVATIVE; CYTIDINE; ENZYME INHIBITOR; N-ACETYLLACTOSAMINIDE ALPHA-2,3-SIALYLTRANSFERASE; SIALYLTRANSFERASE;

ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; SIALYLATION; SUBSTITUTION REACTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CONFORMATION; HUMAN; KINETICS; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CYCLOPENTANES; CYTIDINE; ENZYME INHIBITORS; HUMANS; KINETICS; MOLECULAR CONFORMATION; SIALYLTRANSFERASES;

EID: 84945419989     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01181     Document Type: Article

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