Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1263-1273

  Kikuchi, Haruhisa ^a   Okazaki, Kaori ^a   Sekiya, Mizuki ^a   Uryu, Yasuyuki ^a   Ueda, Kazunori ^a   Katou, Yasuhiro ^a   Kurata, Shoichiro ^a   Oshima, Yoshiteru ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Cyclopentanediol; Drosophila; Immunosuppressor; Innate immunity; TNF

Indexed keywords

1,2 CYCLOPENTANEDIOL DERIVATIVE; 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOHYDROXAMIC ACID; 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOIC ACID; 3 [3,4 (DIMETHYLMETHYLENEDIOXY) 1 CYCLOPENTYL]PROPENAMIDE; 3 [3,4 (DIMETHYLMETHYLENEDIOXY) 1 CYCLOPENTYL]PROPENOIC ACID; 4 HEXYLCYCLOPENTANE 1,2 DIOL; 4 PROPYLCYCLOPENTANE 1,2 DIOL; [3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOYL]PIPERIDINE; CYCLOPENTANEDIOL; ETHYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOATE; HEXYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOATE; IMMUNOSUPPRESSIVE AGENT; METHYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOATE; METHYL 3 [3,4 (DIMETHYLMETHYLENEDIOXY) 1 CYCLOPENTYL]PROPENOATE; N (3,4 DICHLOROPHENYL) 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N (4 CHLOROPHENYL) 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N (4 FLUOROPHENYL) 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N (4 METHYLPHENYL) 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N [4 (DIMETHYLAMINO)PHENYL] 3 [3,4 (DIMETHYLMETHYLENEDIOXY) 1 CYCLOPENTYL]PROPENAMIDE; N [4 (TRIFLUOROMETHYL)PHENYL] 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N BUTYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N CYCLOPROPYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N ETHYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N METHYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N PHENYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; N,N DIMETHYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENAMIDE; PHENYL 3 (3,4 DIHYDROXYCYCLOPENT 1 YL)PROPENOATE; TERT 4 (1 PROPENYL)CYCLOPENTANE 1,2 DIOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; INNATE IMMUNITY; INSECT CELL; NONHUMAN;

AMIDES; ANIMALS; ASPERGILLUS; CELL LINE; CYCLOPENTANES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOTHELIAL CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-8; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952281985     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.049     Document Type: Article

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