Asymmetric synthesis and affinity of potent sialyltransferase inhibitors based on transition-state analogues

Glycoconjugate Journal

Volumn 21, Issue 5, 2004, Pages 205-219

  Skropeta, Danielle ^a   Schwörer, Ralf ^a   Haag, Tobias ^a   Schmidt, Richard R ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

sialyltransferase inhibitors; stereoselective synthesis; transition state analogues

Indexed keywords

BENZYL INHIBITOR; CARBON; CYTIDINE PHOSPHATE; ENZYME INHIBITOR; SIALYLTRANSFERASE INHIBITOR; TRISODIUM CYTIDIN 5' YL [(3 PHENOXY)PHENYLPHOSPHONATOMETHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(3 TRIFLUOROMETHYL)PHENYLPHOSPHONATOMETHYL] PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(4 ACETAMIDO)PHENYLPHOSPHONATOMETHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(4 AMYL)PHENYLPHOSPHONATOMETHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(4 NITRO)PHENYLPHOSPHONATOMETHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(N METHYLPYRIDINIUM 4 YL)PHOSPHONATOMETHYL] PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(NAPHTHALIN 1 YL)PHOSPHONATOMETHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [(NAPHTHALIN 2 YL)PHOSPHONATOMETHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [PHOSPHONATO 1 (6 PYRIMIDINON 4 YL)METHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [PHOSPHONATO(METHYL 2 YL)METHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [PHOSPHONATO(PYRIDIN 2 YL)METHYL]PHOSPHATE; TRISODIUM CYTIDIN 5' YL [PHOSPHONATO(PYRIDIN 4 YL)METHYL]PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; BINDING AFFINITY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; PRIORITY JOURNAL; STEREOCHEMISTRY;

ANIMALS; ENZYME INHIBITORS; KINETICS; LIVER; PHOSPHONIC ACIDS; RATS; SIALYLTRANSFERASES; STEREOISOMERISM;

EID: 6344244586     PISSN: 02820080     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:GLYC.0000045093.96413.62     Document Type: Article

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