Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase

Journal of the American Chemical Society

Volumn 134, Issue 22, 2012, Pages 9343-9351

  Dumbre, Shrinivas ^a   Derouaux, Adeline ^b   Lescrinier, Eveline ^a   Piette, André ^b   Joris, Bernard ^b   Terrak, Mohammed ^b   Herdewijn, Piet ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACCEPTOR SITES; ACTIVE SITE; ANTI-BACTERIAL ACTIVITY; BACILLUS SUBTILIS; BACTERIAL CELLS; BIOLOGICAL EFFECTS; E. COLI; GLYCAN CHAINS; GLYCOSYL TRANSFERASE; GLYCOSYLTRANSFERASES; GROWTH DEFECTS; IN-VITRO; PEPTIDE MOIETY; PEPTIDOGLYCAN PRECURSORS; PEPTIDOGLYCANS;

ANTIBIOTICS; CELL MEMBRANES; ESCHERICHIA COLI;

ENZYMES;

BAMBERMYCIN; GLYCAN; LIPID; PEPTIDOGLYCAN; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; PHOSPHOGLYCERATE N ACETYLMURAMIC ACID (ALANYL DEXTRO GLUTAMINE) N ACETYLGLUCOSAMINE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL WALL; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERIZATION;

MOLECULAR CONFORMATION; PEPTIDOGLYCAN; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861878039     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja302099u     Document Type: Article

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