Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 5737-5747

  Yan, Meng ^a   Zhang, Kaiping ^a   Shi, Yanhui ^a   Feng, Lifang ^a   Lv, Lin ^a   Li, Baoxin ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Key Lab of Biopharmaceut Eng   (China)

Author keywords

Berberine; Cardiotoxicity; Cavoline 1; hERG; LQTS; Pharmacological rescue

Indexed keywords

ASTEMIZOLE; BERBERINE; CAVEOLIN 1; FEXOFENADINE; PHENYLALANINE; POTASSIUM CHANNEL HERG; RESVERATROL; SMALL INTERFERING RNA; TYROSINE; CAV1 PROTEIN, HUMAN; KCNH2 PROTEIN, HUMAN; POTASSIUM CHANNEL BLOCKING AGENT; STILBENE DERIVATIVE; TERFENADINE;

ACTION POTENTIAL DURATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CARDIOTOXICITY; CELL SURFACE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FEMALE; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LONG QT SYNDROME; MALE; NONHUMAN; PATCH CLAMP TECHNIQUE; POTASSIUM CURRENT; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; ACTION POTENTIAL; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; KINETICS; METABOLISM; MUTATION; RNA INTERFERENCE;

ACTION POTENTIALS; BERBERINE; CAVEOLIN 1; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERG1 POTASSIUM CHANNEL; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; KINETICS; MUTATION; PHENYLALANINE; POTASSIUM CHANNEL BLOCKERS; RNA INTERFERENCE; STILBENES; TERFENADINE; TRANSFECTION; TYROSINE;

EID: 84945307206     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S91561     Document Type: Article

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