Block of hERG channels by berberine: Mechanisms of voltage- and state-dependence probed with site-directed mutant channels

Journal of Cardiovascular Pharmacology

Volumn 47, Issue 1, 2006, Pages 21-29

  Rodriguez Menchaca, Aldo ^a   Ferrer Villada, Tania ^a   Lara, Jesus ^a   Fernandez, David ^b   Navarro Polanco, Ricardo A ^a   Sanchez Chapula, Jose A ^a  

^a UNIVERSIDAD DE COLIMA   (Mexico)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Berberine; HEK 293; hERG; IKr; IKs; KCNQ1 KCNE1; Oocytes

Indexed keywords

BERBERINE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNQ1; KCNE1 PROTEIN, HUMAN; KCNQ1 PROTEIN, HUMAN; POTASSIUM CHANNEL BLOCKING AGENT; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; IC 50; MEMBRANE DEPOLARIZATION; MEMBRANE STEADY POTENTIAL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; XENOPUS; ANIMAL; BINDING SITE; CELL LINE; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; OOCYTE; SITE DIRECTED MUTAGENESIS;

ANIMALS; BERBERINE; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; KCNQ1 POTASSIUM CHANNEL; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; XENOPUS;

EID: 33646680764     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000191564.52242.00     Document Type: Article

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