The regulation of the cardiac potassium channel (HERG) by caveolin-1

Biochemistry and Cell Biology

Volumn 86, Issue 5, 2008, Pages 405-415

  Lin, Jijin ^a   Lin, Shuguang ^a   Choy, Patrick C ^b   Shen, Xiuzhang ^c   Deng, Chunyu ^a   Kuang, Sujuan ^a   Wu, Jun ^c   Xu, Wencan ^c  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

^c SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Caveolin 1; HERG; Lipid rafts; Potassium channel; Protein protein interaction

Indexed keywords

CELL MEMBRANES; ETHERS; LAWS AND LEGISLATION; NUCLEIC ACIDS; ORGANIC COMPOUNDS; POTASSIUM; PROTEINS; RNA;

BIOLOGICAL PROCESSES; CARDIAC PATIENTS; CAVEOLIN; CAVEOLIN-1; CDNA LIBRARIES; CELLULAR PROTEINS; COIMMUNOPRECIPITATION ASSAYS; CURRENT AMPLITUDES; DISRUPTION MODELS; HERG; HERG CHANNELS; HUMAN HEARTS; HYBRID SYSTEMS; IMMUNOCYTOCHEMISTRY; LIPID RAFTS; LONG QT SYNDROMES; MEMBRANE LIPIDS; N TERMINUSES; POTASSIUM CHANNEL; POTASSIUM CHANNELS; PROTEIN INTERACTIONS; REGULATORY; RNA INTERFERENCES; SUBCELLULAR LOCALIZATIONS; TAIL CURRENTS;

FLOW INTERACTIONS;

CAVEOLIN 1; CELL PROTEIN; COMPLEMENTARY DNA; MEMBRANE LIPID; POTASSIUM CHANNEL HERG;

AMINO TERMINAL SEQUENCE; AMPLITUDE MODULATION; ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FLUORESCENCE; GENE CONTROL; GENE OVEREXPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; LIPID RAFT; MOLECULAR CLONING; NONHUMAN; PATCH CLAMP; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA INTERFERENCE; TWO HYBRID SYSTEM; WHOLE CELL;

ANIMALS; CAVEOLIN 1; CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART; HUMANS; LONG QT SYNDROME; MEMBRANE MICRODOMAINS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RNA INTERFERENCE; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 54249134965     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/O08-118     Document Type: Article

References (42)

1. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell, 97: 175-187. doi:10.1016/S0092-8674(00)80728-X. PMID:10219239.
2. Ca channels and caveolin-rich domains. Br. J. Pharmacol. 151: 332-340. doi:10.1038/sj.bjp.0707222. PMID:17450174.
3. + channel. Pflugers Arch. 455: 105-113. doi:10.1007/s00424-007-0292-5. PMID:17622552.
4. Brugada, R., Hong, K., Dumaine, R., Cordeiro, J., Gaita, F., Borggrefe, M., et al. 2004. Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation, 109: 30-35. doi:10.1161/01.CIR. 0000109482.92774.3A. PMID:14676148.
5. Cao, H., Courchesne, W.E., and Mastick, C.C. 2002. A phosphotyrosine- dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J. Biol. Chem. 277: 8771-8774. doi:10.1074/jbc.C100661200. PMID:11805080.
6. + current by Src tyrosine kinase. J. Biol. Chem. 277: 13673-13681. doi:10.1074/jbc.M108211200. PMID:11834728.
7. 2A receptors, caveolin-1, and KV1.5 channel internalization. Circ. Res. 98: 931-938. doi:10.1161/01.RES.0000216858.04599.e1. PMID:16527989.
8. Couet, J., Li, S., Okamoto, T., Ikezu, T., and Lisanti, M.P. 1997. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J. Biol. Chem. 272: 6525-6533. doi:10.1074/jbc.272.48.30429. PMID:9045678.
9. Crociani, O., Guasti, L., Balzi, M., Becchetti, A., Wanke, E., Olivotto, M., et al. 2003. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J. Biol. Chem. 278: 2947-2955. doi:10.1074/jbc.M210789200. PMID:12431979.
10. + channel by dual pathways. Curr. Biol. 10: 671-674. doi:10.1016/S0960-9822(00)00516-9. PMID:10837251.
11. Curran, M.E., Splawski, I., Timothy, K.W., Vincent, G.M., Green, E.D., and Keating, M.T. 1995. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell, 80: 795-803. doi:10.1016/0092-8674(95) 90358-5. PMID:7889573.
12. Folco, E.J., Liu, G.X., and Koren, G. 2004. Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5. Am. J. Physiol. Heart Circ. Physiol. 287: H681-H690. doi:10.1152/ajpheart.00152.2004. PMID:15277200.
13. Ju, H., Zou, R., Venema, V.J., and Venema, R.C. 1997. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J. Biol. Chem. 272: 18522-18525. doi:10.1074/jbc.272.30.18522. PMID:9228013.
14. Kr by PKA-mediated interactions with 14-3-3 [discussion 89-99]. In Novartis Foundation Symposium 266 - The hERG Cardiac Potassium Channel: Structure, Function, and Long QT Syndrome. Vol. 266. Edited by D.J. Chadwick and J. Goode. pp. 75-89. doi:10.1002/047002142X.ch7. PMID:16050263.
15. + channel activity. EMBO J. 21: 1889-1898. doi:10.1093/emboj/21.8.1889. PMID:11953308.
16. Levin, A.M., Murase, K., Jackson, P.J., Flinspach, M.L., Poulos, T.L., and Weiss, G.A. 2007. Double barrel shotgun scanning of the caveolin-1 scaffolding domain. ACS Chem. Biol. 2: 493-500. doi:10.1021/cb700055t. PMID:17602618.
17. Lin, J., Friesen, M.T., Bocangel, P., Cheung, D., Rawszer, K., and Wigle, J.T. 2005. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. Mol. Cell. Biochem. 275: 75-84. doi:10.1007/s11010-005-0823-3. PMID:16335786.
18. Lisanti, M.P., Scherer, P.E., Tang, Z., and Sargiacomo, M. 1994. Caveolae, caveolin, and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol. 4: 231-235. doi:10.1016/0962-8924(94)90114-7. PMID:14731661.
19. Liu, J., Razani, B., Tang, S., Terman, B.I., Ware, J.A., and Lisanti, M.P. 1999. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. J. Biol. Chem. 274: 15781-15785. doi:10.1074/jbc.274.22.15781. PMID:10336480.
20. Morris, J.B., Huynh, H., Vasilevski, O., and Woodcock, E.A. 2006. α1-Adrenergic receptor signaling is localized to caveolae in neonatal rat cardiomyocytes. J. Mol. Cell. Cardiol. 41: 17-25. doi:10.1016/j.yjmcc. 2006.03.011. PMID:16730745.
21. Oh, P., and Schnitzer, J.E. 2001. Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol. Biol. Cell, 12: 685-698. PMID:11251080.
22. Okamoto, T., Schlegel, A., Scherer, P.E., and Lisanti, M.P. 1998. Caveolins, a family of scaffolding proteins for organizing "pre-assembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273: 5419-5422. doi:10.1074/jbc.273.10.5419. PMID:9488658.
23. Ostrom, R.S., Violin, J.D., Coleman, S., and Insel, P.A. 2000. Selective enhancement of β-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Mol. Pharmacol. 57: 1075-1079. PMID:10779394.
24. Razani, B., and Lisanti, M.P. 2001. Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am. J. Physiol. Cell Physiol. 281: C1241-C1250. PMID:11546661.
25. Razani, B., Rubin, C.S., and Lisanti, M.P. 1999. Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A. J. Biol. Chem. 274: 26353-26360. doi:10.1074/jbc.274.37.26353. PMID:10473592.
26. Razani, B., Woodman, S.E., and Lisanti, M.P. 2002. Caveolae: from cell biology to animal physiology. Pharmacol. Rev. 54: 431-467. doi:10.1124/pr.54.3.431. PMID:12223531.
27. Redfern, W.S., Carlsson, L., Davis, A.S., Lynch, W.G., MacKenzie, I., Palethorpe, S., et al. 2003. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation, and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58: 32-45. doi:10.1016/S0008-6363(02)00846- 5. PMID:12667944.
28. Roti, E.C., Myers, C.D., Ayers, R.A., Boatman, D.E., Delfosse, S.A., Chan, E.K., et al. 2002. Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. J. Biol. Chem. 277: 47779-47785. doi:10.1074/jbc.M206638200. PMID:12270925.
29. Rybin, V.O., Xu, X., and Steinberg, S.F. 1999. Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation. Circ. Res. 84: 980-988. PMID:10325235.
30. Rybin, V.O., Xu, X., Lisanti, M.P., and Steinberg, S.F. 2000. Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J. Biol. Chem. 275: 41447-41457. doi:10.1074/jbc. M006951200. PMID:11006286.
31. Sampson, L.J., Hayabuchi, Y., Standen, N.B., and Dart, C. 2004. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Circ. Res. 95: 1012-1018. doi:10.1161/01.RES.0000148634.47095. ab. PMID:15499025.
32. Sampson, L.J., Davies, L.M., Barrett-Jolley, R., Standen, N.B., and Dart, C. 2007. Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels. Cardiovasc. Res. 76: 61-70. doi:10.1016/j.cardiores.2007.05.020. PMID:17582389.
33. Sanguinetti, M.C., and Tristani-Firouzi, M. 2006. hERG potassium channels and cardiac arrhythmia. Nature, 440: 463-469. doi:10.1038/nature04710. PMID:16554806.
34. Kr potassium channel. Cell, 81: 299-307. doi:10.1016/0092-8674(95)90340-2. PMID:7736582.
35. Schwencke, C., Okumura, S., Yamamoto, M., Geng, Y.J., and Ishikawa, Y. 1999. Colocalization of β-adrenergic receptors and caveolin within the plasma membrane. J. Cell. Biochem. 75: 64-72. doi:10.1002/(SICI)1097- 4644(19991001)75:1〈64::AID-JCB7〉3.0.CO;2-L. PMID:10462705.
36. Stubbs, C.D., Botchway, S.W., Slater, S.J., and Parker, A.W. 2005. The use of time-resolved fluorescence imaging in the study of protein kinase C localisation in cells. BMC Cell Biol. 6: 22. doi:10.1186/1471-2121-6-22. PMID:15854225.
37. Thomas, D., Zhang, W., Karle, C.A., Kathofer, S., Schols, W., Kubler, W., and Kiehn, J. 1999. Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J. Biol. Chem. 274: 27457-27462. doi:10.1074/jbc.274.39.27457. PMID:10488078.
38. Toya, Y., Schwencke, C., Couet, J., Lisanti, M.P., and Ishikawa, Y. 1998. Inhibition of adenylyl cyclase by caveolin peptides. Endocrinology, 139: 2025-2031. doi:10.1210/en.139.4.2025. PMID:9528990.
39. Trudeau, M.C., Warmke, J.W., Ganetzky, B., and Robertson, G.A. 1995. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science, 269: 92-95. doi:10.1126/science.7604285. PMID:7604285.
40. + channels in vascular endothelial cells. J. Biol. Chem. 280: 11656-11664. doi:10.1074/jbc.M410987200. PMID:15665381.
41. 2-adrenoceptors in neonatal cardiac myocytes. J. Biol. Chem. 277: 34280-34286. doi:10.1074/jbc.M201644200. PMID:12097322.
42. Zhou, Z., Gong, Q., Ye, B., Fan, Z., Makielski, J.C., Robertson, G.A., and January, C.T. 1998. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys. J. 74: 230-241. PMID:9449325.