Berberine induces hERG channel deficiency through trafficking inhibition

Cellular Physiology and Biochemistry

Volumn 34, Issue 3, 2014, Pages 691-702

  Zhang, Kaiping ^a   Zhi, Duo ^a   Huang, Ting ^a   Gong, Yan ^a   Yan, Meng ^a   Liu, Chen ^a   Wei, Ting ^a   Dong, Zengxiang ^a,b   Li, Baoxin ^a,b   Yang, Baofeng ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Arrhythmia; Berberine; Endoplasmic reticulum stress response; hERG; Long QT Syndrome; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BERBERINE; CALNEXIN; CALRETICULIN; CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; POTASSIUM CHANNEL HERG; PROTEASOME; ERG1 POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; EXPERIMENTAL GUINEA PIG; FEMALE; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LYSOSOME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; QT INTERVAL; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DEFICIENCY; FLUORESCENT ANTIBODY TECHNIQUE; GUINEA PIG; HEK293 CELL LINE; METABOLISM; PROTEIN TRANSPORT;

ANIMALS; BERBERINE; BLOTTING, WESTERN; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GUINEA PIGS; HEK293 CELLS; HUMANS; MALE; PROTEIN TRANSPORT;

EID: 84906588777     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000363034     Document Type: Article

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