Arsenic trioxide-induced hERG K+ channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression

Biochemical Pharmacology

Volumn 85, Issue 1, 2013, Pages 59-68

  Zhang, Ying ^a,b   Dong, Zengxiang ^a,b   Jin, Liyan ^a   Zhang, Kaiping ^a   Zhao, Xin ^a   Fu, Jia ^a   Gong, Yan ^a   Sun, Mingming ^a   Yang, Baofeng ^a,b   Li, Baoxin ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

As2O3; hERG; Matrine; Oxymatrine; Sp1

Indexed keywords

ARSENIC TRIOXIDE; MATRINE; MESSENGER RNA; OXYMATRINE; POTASSIUM CHANNEL HERG; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CARDIOTOXICITY; CELL LEVEL; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; HEART PROTECTION; LONG QT SYNDROME; LONG TERM CARE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ACTION POTENTIALS; ALKALOIDS; ANIMALS; ARSENICALS; CARDIOVASCULAR AGENTS; ETHER-A-GO-GO POTASSIUM CHANNELS; GUINEA PIGS; HEK293 CELLS; HUMANS; MYOCYTES, CARDIAC; OXIDES; PATCH-CLAMP TECHNIQUES; PROMOTER REGIONS, GENETIC; QUINOLIZINES; SP1 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84871716097     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.09.002     Document Type: Article

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