Effective incorporation of insulin in mucus permeating self-nanoemulsifying drug delivery systems

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 97, Issue , 2015, Pages 223-229

  Karamanidou, Theodora ^a   Karidi, Konstantina ^b   Bourganis, Vassilis ^a   Kontonikola, Katerina ^a,b   Kammona, Olga ^b   Kiparissides, Costas ^a,b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

Author keywords

Dimyristoyl phosphatidylglycerol; Insulin; Ionic complexation; Mucus; Oral delivery; SNEDDS

Indexed keywords

CHYMOTRYPSIN A; CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; DIMYRISTOYLPHOSPHATIDYLGLYCEROL; LABRAFIL M1944CS; LAUROGLYCOL FCC; OIL; PIG INSULIN; TRYPSIN; UNCLASSIFIED DRUG; DRUG CARRIER; EMULSION; INSULIN; NANOPARTICLE; PHOSPHATIDYLGLYCEROL; SURFACTANT;

ARTICLE; CELL VIABILITY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFUSION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; ENZYMATIC DEGRADATION; IN VITRO STUDY; IONIC STRENGTH; MOLECULAR WEIGHT; MTT ASSAY; MUCUS; NANOEMULSION; PARTICLE SIZE; SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM; ANIMAL; CHEMISTRY; DRUG RELEASE; EMULSION; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PERMEABILITY; PHASE TRANSITION; PIG; PROCEDURES;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; EMULSIONS; INSULIN; MUCUS; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; PHASE TRANSITION; PHOSPHATIDYLGLYCEROLS; SURFACE-ACTIVE AGENTS; SWINE;

EID: 84945277803     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.04.013     Document Type: Article

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