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Volumn 10, Issue 2, 2014, Pages

miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MICRORNA; MICRORNA 100; MICRORNA 125B; MICRORNA 22; MICRORNA 720; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; FIZZY RELATED PROTEIN; FZR1 PROTEIN, HUMAN; HOMEOBOX A1 PROTEIN; HOMEODOMAIN PROTEIN; MIRN100 MICRORNA, HUMAN; TRANSCRIPTION FACTOR;

EID: 84901741348     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004177     Document Type: Article
Times cited : (110)

References (44)
  • 1
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP, (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 2
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA, (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 3
    • 37549071388 scopus 로고    scopus 로고
    • Adaptation versus selection: the origins of metastatic behavior
    • Scheel C, Onder T, Karnoub A, Weinberg RA, (2007) Adaptation versus selection: the origins of metastatic behavior. Cancer Res 67: 11476-11479 discussion 11479-11480.
    • (2007) Cancer Res , vol.67 , pp. 11476-11479
    • Scheel, C.1    Onder, T.2    Karnoub, A.3    Weinberg, R.A.4
  • 4
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5
  • 5
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, Peter ME, (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22: 894-907.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 6
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, et al. (2009) Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138: 592-603.
    • (2009) Cell , vol.138 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3    Lobo, N.4    Dalerba, P.5
  • 7
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, et al. (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11: 1487-1495.
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3    Schmalhofer, O.4    Zhu, F.5
  • 8
    • 84868000009 scopus 로고    scopus 로고
    • MicroRNA control of epithelial-mesenchymal transition and metastasis
    • Zhang J, Ma L, (2012) MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metastasis Rev 31: 653-662.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 653-662
    • Zhang, J.1    Ma, L.2
  • 9
    • 77649275464 scopus 로고    scopus 로고
    • miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    • Ma L, Young J, Prabhala H, Pan E, Mestdagh P, et al. (2010) miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12: 247-256.
    • (2010) Nat Cell Biol , vol.12 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3    Pan, E.4    Mestdagh, P.5
  • 10
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not-routes towards metastasis
    • Brabletz T, (2012) To differentiate or not-routes towards metastasis. Nat Rev Cancer 12: 425-436.
    • (2012) Nat Rev Cancer , vol.12 , pp. 425-436
    • Brabletz, T.1
  • 11
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J, (2012) Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22: 725-736.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 12
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, et al. (2012) Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 22: 709-724.
    • (2012) Cancer Cell , vol.22 , pp. 709-724
    • Ocana, O.H.1    Corcoles, R.2    Fabra, A.3    Moreno-Bueno, G.4    Acloque, H.5
  • 13
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5
  • 14
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, et al. (2008) Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 3: e2888.
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5
  • 15
    • 84860578009 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    • Celia-Terrassa T, Meca-Cortes O, Mateo F, de Paz AM, Rubio N, et al. (2012) Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest 122: 1849-1868.
    • (2012) J Clin Invest , vol.122 , pp. 1849-1868
    • Celia-Terrassa, T.1    Meca-Cortes, O.2    Mateo, F.3    de Paz, A.M.4    Rubio, N.5
  • 16
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, et al. (2001) Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 15: 50-65.
    • (2001) Genes Dev , vol.15 , pp. 50-65
    • Elenbaas, B.1    Spirio, L.2    Koerner, F.3    Fleming, M.D.4    Zimonjic, D.B.5
  • 17
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Comprehensive molecular portraits of human breast tumours. Nature 490: 61-70.
    • Nature , vol.490 , pp. 61-70
  • 18
    • 79951828224 scopus 로고    scopus 로고
    • miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation
    • Sun D, Lee YS, Malhotra A, Kim HK, Matecic M, et al. (2011) miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation. Cancer Res 71: 1313-1324.
    • (2011) Cancer Res , vol.71 , pp. 1313-1324
    • Sun, D.1    Lee, Y.S.2    Malhotra, A.3    Kim, H.K.4    Matecic, M.5
  • 19
    • 84864286762 scopus 로고    scopus 로고
    • MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2
    • Zeng Y, Qu X, Li H, Huang S, Wang S, et al. (2012) MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2. FEBS Lett 586: 2375-2381.
    • (2012) FEBS Lett , vol.586 , pp. 2375-2381
    • Zeng, Y.1    Qu, X.2    Li, H.3    Huang, S.4    Wang, S.5
  • 20
    • 0037470044 scopus 로고    scopus 로고
    • Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene
    • Zhang X, Zhu T, Chen Y, Mertani HC, Lee KO, et al. (2003) Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene. J Biol Chem 278: 7580-7590.
    • (2003) J Biol Chem , vol.278 , pp. 7580-7590
    • Zhang, X.1    Zhu, T.2    Chen, Y.3    Mertani, H.C.4    Lee, K.O.5
  • 21
    • 0030585383 scopus 로고    scopus 로고
    • Detection of HOXA1 expression in human breast cancer
    • Chariot A, Castronovo V, (1996) Detection of HOXA1 expression in human breast cancer. Biochem Biophys Res Commun 222: 292-297.
    • (1996) Biochem Biophys Res Commun , vol.222 , pp. 292-297
    • Chariot, A.1    Castronovo, V.2
  • 22
    • 2142653519 scopus 로고    scopus 로고
    • DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
    • Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Robertson KD, (2004) DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun 318: 544-555.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 544-555
    • Geiman, T.M.1    Sankpal, U.T.2    Robertson, A.K.3    Zhao, Y.4    Robertson, K.D.5
  • 24
    • 0026599290 scopus 로고
    • Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6
    • Chisaka O, Musci TS, Capecchi MR, (1992) Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature 355: 516-520.
    • (1992) Nature , vol.355 , pp. 516-520
    • Chisaka, O.1    Musci, T.S.2    Capecchi, M.R.3
  • 25
    • 0025864268 scopus 로고
    • Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
    • Lufkin T, Dierich A, LeMeur M, Mark M, Chambon P, (1991) Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell 66: 1105-1119.
    • (1991) Cell , vol.66 , pp. 1105-1119
    • Lufkin, T.1    Dierich, A.2    LeMeur, M.3    Mark, M.4    Chambon, P.5
  • 26
    • 80052167697 scopus 로고    scopus 로고
    • Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development
    • Makki N, Capecchi MR, (2011) Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol 357: 295-304.
    • (2011) Dev Biol , vol.357 , pp. 295-304
    • Makki, N.1    Capecchi, M.R.2
  • 28
    • 0034721665 scopus 로고    scopus 로고
    • Transducing the hedgehog signal
    • Kalderon D, (2000) Transducing the hedgehog signal. Cell 103: 371-374.
    • (2000) Cell , vol.103 , pp. 371-374
    • Kalderon, D.1
  • 31
    • 34447345999 scopus 로고    scopus 로고
    • Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells
    • Herman JG, Meadows GG, (2007) Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells. Int J Oncol 30: 1231-1238.
    • (2007) Int J Oncol , vol.30 , pp. 1231-1238
    • Herman, J.G.1    Meadows, G.G.2
  • 32
    • 0029111934 scopus 로고
    • Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    • Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, et al. (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82: 621-630.
    • (1995) Cell , vol.82 , pp. 621-630
    • Sicinski, P.1    Donaher, J.L.2    Parker, S.B.3    Li, T.4    Fazeli, A.5
  • 33
    • 0028243879 scopus 로고
    • Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    • Wang TC, Cardiff RD, Zukerberg L, Lees E, Arnold A, et al. (1994) Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369: 669-671.
    • (1994) Nature , vol.369 , pp. 669-671
    • Wang, T.C.1    Cardiff, R.D.2    Zukerberg, L.3    Lees, E.4    Arnold, A.5
  • 35
    • 84874668049 scopus 로고    scopus 로고
    • Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype
    • Karihtala P, Auvinen P, Kauppila S, Haapasaari KM, Jukkola-Vuorinen A, et al. (2013) Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype. Breast Cancer Res Treat 138: 81-90.
    • (2013) Breast Cancer Res Treat , vol.138 , pp. 81-90
    • Karihtala, P.1    Auvinen, P.2    Kauppila, S.3    Haapasaari, K.M.4    Jukkola-Vuorinen, A.5
  • 36
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA, (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 37
    • 1642430733 scopus 로고    scopus 로고
    • Myc pathways provoking cell suicide and cancer
    • Nilsson JA, Cleveland JL, (2003) Myc pathways provoking cell suicide and cancer. Oncogene 22: 9007-9021.
    • (2003) Oncogene , vol.22 , pp. 9007-9021
    • Nilsson, J.A.1    Cleveland, J.L.2
  • 38
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, et al. (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1: 555-567.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5
  • 39
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, et al. (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270.
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3    Jackson, K.W.4    Clarke, M.F.5
  • 40
    • 84880305345 scopus 로고    scopus 로고
    • miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling
    • Gebeshuber CA, Martinez J, (2013) miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling. Oncogene 32: 3306-3310.
    • (2013) Oncogene , vol.32 , pp. 3306-3310
    • Gebeshuber, C.A.1    Martinez, J.2
  • 41
    • 84880570961 scopus 로고    scopus 로고
    • MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling
    • Song SJ, Poliseno L, Song MS, Ala U, Webster K, et al. (2013) MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell 154: 311-324.
    • (2013) Cell , vol.154 , pp. 311-324
    • Song, S.J.1    Poliseno, L.2    Song, M.S.3    Ala, U.4    Webster, K.5
  • 42
    • 0344375083 scopus 로고    scopus 로고
    • Lentivirus-delivered stable gene silencing by RNAi in primary cells
    • Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, et al. (2003) Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9: 493-501.
    • (2003) RNA , vol.9 , pp. 493-501
    • Stewart, S.A.1    Dykxhoorn, D.M.2    Palliser, D.3    Mizuno, H.4    Yu, E.Y.5
  • 43
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP, (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 44
    • 4644237189 scopus 로고    scopus 로고
    • Fast and effective prediction of microRNA/target duplexes
    • Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R, (2004) Fast and effective prediction of microRNA/target duplexes. RNA 10: 1507-1517.
    • (2004) RNA , vol.10 , pp. 1507-1517
    • Rehmsmeier, M.1    Steffen, P.2    Hochsmann, M.3    Giegerich, R.4


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