Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

British Journal of Pharmacology

Volumn 172, Issue 20, 2015, Pages 4932-4945

  Peters, E ^a   Geraci, S ^b   Heemskerk, S ^a   Wilmer, M J ^a   Bilos, A ^a   Kraenzlin, B ^b   Gretz, N ^b   Pickkers, P ^a   Masereeuw, R ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; KIDNEY INJURY MOLECULE 1; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTECTIVE AGENT; PROTEIN BAX; PURINERGIC P2 RECEPTOR; RECOMBINANT ALKALINE PHOSPHATASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOKINE; FLUORESCEIN DERIVATIVE; FLUORESCEIN-ISOTHIOCYANATE SINISTRIN; OLIGOSACCHARIDE; PURINE DERIVATIVE; RECOMBINANT PROTEIN; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG RECEPTOR BINDING; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; KIDNEY TUBULE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RENAL PROTECTION; SEPSIS; SPRAGUE DAWLEY RAT; ACUTE KIDNEY INJURY; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; INFLAMMATION; KIDNEY; METABOLISM; PATHOLOGY; URINE;

ACUTE KIDNEY INJURY; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ALKALINE PHOSPHATASE; ANIMALS; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; FLUORESCEINS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; KIDNEY; LIPOPOLYSACCHARIDES; MALE; OLIGOSACCHARIDES; PROTECTIVE AGENTS; PURINES; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRIAZINES; TRIAZOLES;

EID: 84945267904     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13261     Document Type: Article

References (38)

1. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al., (2013a). The concise guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol 170: 1459-1581.
2. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al., (2013b). The concise guide to PHARMACOLOGY 2013/14: ligand-gated ion channels. Br J Pharmacol 170: 1582-1606.
3. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al., (2013c). The concise guide to PHARMACOLOGY 2013/14: catalytic receptors. Br J Pharmacol 170: 1676-1705.
4. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al., (2013d). The concise guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol 170: 1797-1867.
5. Bauerle JD, Grenz A, Kim JH, Lee HT, Eltzschig HK, (2011). Adenosine generation and signaling during acute kidney injury. JASN 22: 14-20.
6. Bentala H, Verweij WR, Huizinga-Van der Vlag A, van Loenen-Weemaes AM, Meijer DK, Poelstra K, (2002). Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide. Shock 18: 561-566.
7. Bonventre JV, (2008). Kidney injury molecule-1 (KIM-1): a specific and sensitive biomarker of kidney injury. Scand J Clin Lab Invest Suppl 241: 78-83.
8. Case J, Khan S, Khalid R, Khan A, (2013). Epidemiology of acute kidney injury in the intensive care unit. Crit Care Res Pract 2013: 2013: 479730.
9. Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, et al., (2010). Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. American journal of physiology. Gastrointest Liver Physiol 299: G467-G475.
10. Cohen J, (2002). The immunopathogenesis of sepsis. Nature 420: 885-891.
11. Devarajan P, (2011). Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr 23: 194-200.
12. Di Sole F, (2008). Adenosine and renal tubular function. Curr Opin Nephrol Hypertens 17: 399-407.
13. Eltzschig HK, Eckle T, (2011). Ischemia and reperfusion-from mechanism to translation. Nat Med 17: 1391-1401.
14. Eltzschig HK, Sitkovsky MV, Robson SC, (2012). Purinergic signaling during inflammation. N Engl J Med 367: 2322-2333.
15. Goldberg R, Dennen P, (2008). Long-term outcomes of acute kidney injury. Adv Chronic Kidney Dis 15: 297-307.
16. Good DW, George T, Watts BA III, (2009). Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes. American journal of physiology. Ren Physiol 297: F866-F874.
17. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, et al., (2012). Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest 122: 693-710.
18. Hasko G, Pacher P, (2008). A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol 83: 447-455.
19. Heemskerk S, Masereeuw R, Moesker O, Bouw MP, van der Hoeven JG, Peters WH, et al., (2009). Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med 37: 417-423, e411.
20. Ince C, (2005). The microcirculation is the motor of sepsis. Crit Care 9 (Suppl 4): S13-S19.
21. Kalakeche R, Hato T, Rhodes G, Dunn KW, El-Achkar TM, Plotkin Z, et al., (2011). Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment. JASN 22: 1505-1516.
22. Khundmiri SJ, Asghar M, Khan F, Salim S, Yusufi AN, (1997). Effect of reversible and irreversible ischemia on marker enzymes of BBM from renal cortical PT subpopulations. Am J Physiol 273 (6 Pt 2): F849-F856.
23. Kiffer-Moreira T, Sheen CR, Gasque KC, Bolean M, Ciancaglini P, van Elsas A, et al., (2014). Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential. PLoS One 9: e89374.
24. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, Group NCRRGW (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
25. McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
26. Moghadasali R, Mutsaers HA, Azarnia M, Aghdami N, Baharvand H, Torensma R, et al., (2013). Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity. Exp Toxicol Pathol 65: 595-600.
27. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al., (2014). The IUPHAR/BPS guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res 42: D1098-D1106.
28. Peacock WF, Maisel A, Kim J, Ronco C, (2013). Neutrophil gelatinase-associated lipocalin in acute kidney injury. Postgrad Med 125: 82-93.
29. Peters E, Heemskerk S, Masereeuw R, Pickkers P, (2014). Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically III patients. Am J Kidney Dis 63: 1038-1048.
30. Pickkers P, Heemskerk S, Schouten J, Laterre PF, Vincent JL, Beishuizen A, et al., (2012). Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care 16: R14.
31. Romanovsky A, Morgan C, Bagshaw SM, (2014). Pathophysiology and management of septic acute kidney injury. Pediatr Nephrol 29: 1-12.
32. Schock-Kusch D, Sadick M, Henninger N, Kraenzlin B, Claus G, Kloetzer HM, et al., (2009). Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats. Eur Nephrol Dial Transpl Assoc 24: 2997-3001.
33. Schock-Kusch D, Xie Q, Shulhevich Y, Hesser J, Stsepankou D, Sadick M, et al., (2011). Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves. Kidney Int 79: 1254-1258.
34. Solini A, Usuelli V, Fiorina P, (2015). The dark side of extracellular ATP in kidney diseases. J Am Soc Nephrol 26: 1007-1016.
35. Vallon V, Muhlbauer B, Osswald H, (2006). Adenosine and kidney function. Physiol Rev 86: 901-940.
36. Weinberg JM, Venkatachalam MA, (2012). Preserving postischemic reperfusion in the kidney: a role for extracellular adenosine. J Clin Invest 122: 493-496.
37. Wilmer MJ, Saleem MA, Masereeuw R, Ni L, van der Velden TJ, Russel FG, et al., (2010). Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell Tissue Res 339: 449-457.
38. Yap SC, Lee HT, (2012). Adenosine and protection from acute kidney injury. Curr Opin Nephrol Hypertens 21: 24-32.