Preserving postischemic reperfusion in the kidney: A role for extracellular adenosine

Journal of Clinical Investigation

Volumn 122, Issue 2, 2012, Pages 493-496

  Weinberg, Joel M ^a   Venkatachalam, Manjeri A ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A2B RECEPTOR; DIPYRIDAMOLE; NUCLEOSIDE TRANSPORTER; NUCLEOTIDE TRANSPORTER;

ACUTE KIDNEY FAILURE; ENDOTHELIUM CELL; HUMAN; KIDNEY ISCHEMIA; KIDNEY PERFUSION; KIDNEY PROXIMAL TUBULE; NOTE; PRIORITY JOURNAL; REPERFUSION INJURY;

ACUTE KIDNEY INJURY; ANIMALS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; HUMANS; ISCHEMIA; REGIONAL BLOOD FLOW;

EID: 84856517752     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI60957     Document Type: Note

References (25)

1. Thadhani R, Pascual M, Bonventre JV. Medical progress - acute renal failure. N Engl J Med. 1996;334(22):1448-1460.
2. Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK. Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol. 2010;298(5):F1078-F1094.
3. Rosner MH, Portilla D, Okusa MD. Cardiac surgery as a cause of acute kidney injury: pathogenesis and potential therapies. J Intensive Care Med. 2008;23(1):3-18.
4. Jo SK, Rosner MH, Okusa MD. Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon. Clin J Am Soc Nephrol. 2007;2(2):356-365.
5. Grenz A, et al. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2012;122(2):693-710.
6. Weinberg JM. The cell biology of ischemic renal injury. Kidney Int. 1991;39(3):476-500.
7. Grenz A, Homann D, Eltzschig HK. Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid Redox Signal. 2011;15(8):2221-2234.
8. Vallon V, Rieg T. Regulation of renal NaCl and water transport by the ATP/UTP/P2Y(2) receptor system. Am J Physiol Renal Physiol. 2011;301(3):F463- F475.
9. Kishore BK, et al. Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Am J Physiol Renal Physiol. 2005;288(5):F1032-F1043. (Pubitemid 40575711)
10. Vallon V, Muhlbauer B, Osswald H. Adenosine and kidney function. Physiol Rev. 2006;86(3):901-940. (Pubitemid 44033385)
11. Castrop H, et al. Impairment of tubuloglomerular feedback regulation of GFR in ecto-5′-nucleotidase/CD73-deficient mice. J Clin Invest. 2004;114(5):634-642. (Pubitemid 39578753)
12. Al-Mashhadi RH, Skott O, Vanhoutte PM, Hansen PB. Activation of A(2) adenosine receptors dilates cortical efferent arterioles in mouse. Kidney Int. 2009;75(8):793-799.
13. Kim M, et al. Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury. Kidney Int. 2009;75(8):809-823.
14. Laubach VE, French BA, Okusa MD. Targeting of adenosine receptors in ischemia-reperfusion injury. Expert Opin Ther Targets. 2011;15(1):103-118.
15. Grenz A, et al. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med. 2008;5(6):e137.
16. Weinberg JM. Adenine nucleotide metabolism by isolated kidney tubules during oxygen deprivation. Biochem Med Metab Biol. 1988;39(3):319-329.
17. Hanner F, Sorensen CM, Holstein-Rathlou NH, Peti-Peterdi J. Connexins and the kidney. Am J Physiol Regul Integr Comp Physiol. 2010;298(5):R1143-R1155.
18. Lehir M, Kaissling B. Distribution and regulation of renal ecto-5′-nucleotidase: implications for physiological functions of adenosine. Am J Physiol. 1993;264(3 pt 2):F377-F387. (Pubitemid 23102748)
19. Weinberg JM, Davis JA, Lawton A, Abarzua M. Modulation of cell nucleotide levels of isolated kidney tubules. Am J Physiol. 1988;254(3 pt 2):F311-F322.
20. Wilson JM, et al. The A(2B) The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6. J Immunol. 2011;186(12):6746-6752.
21. Lin JJ, Churchill PC, Bidani AK. The effect of dipyridamole on the initiation phase of postischemic acute renal failure in rats. Can J Physiol Pharmacol. 1987;65(7):1491-1495. (Pubitemid 17146437)
22. Lieberthal W, Nigam SK. Acute renal failure. I. Relative importance of proximal vs. distal tubular injury. Am J Physiol. 1998;275(5 pt 2):F623-F631.
23. Mason J, Torhorst J, Welsch J. Role of the medullary perfusion defect in the pathogenesis of ischemic renal failure. Kidney Int. 1984;26(3):283-293. (Pubitemid 14021699)
24. Brodsky SV, et al. Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells. Am J Physiol Renal Physiol. 2002;282(6):F1140-F1149. (Pubitemid 34654480)
25. Sutton TA, Fisher CJ, Molitoris BA. Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int. 2002;62(5):1539-1549. (Pubitemid 35286261)