Mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) overexpression is associated with tumor cell proliferation and is a novel target for drug development

Molecular Cancer Research

Volumn 13, Issue 10, 2015, Pages 1361-1366

  Tedeschi, Philip M ^a   Vazquez, Alexei ^b   Kerrigan, John E ^a   Bertino, Joseph R ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; METHOTREXATE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; HYDROLASE; METHYLENE TETRAHYDROFOLATE DEHYDROGENASE-METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; MULTIENZYME COMPLEX;

BURKITT LYMPHOMA; CANCER INHIBITION; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SENSITIVITY; ENZYME ACTIVITY; HUMAN; LARGE CELL LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; TUMOR CELL; UPREGULATION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MITOCHONDRION; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; MOUSE; NEOPLASMS; PATHOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

AMINOHYDROLASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DRUG DESIGN; HUMANS; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MICE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; MULTIENZYME COMPLEXES; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84945250646     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-15-0117     Document Type: Review

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