Overexpression of the mitochondrial folate and glycine- Serine pathway: A new determinant of methotrexate selectivity in tumors

Cancer Research

Volumn 73, Issue 2, 2013, Pages 478-482

  Vazquez, Alexei ^a   Tedeschi, Philip M ^b   Bertino, Joseph R ^c  

^a Center for Systems Biology   (United States)

^b Graduate School of Biomedical Sciences   (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; GLYCINE; METHOTREXATE; MITOCHONDRIAL ENZYME; PURINE; SERINE; THYMIDINE PHOSPHATE;

AMINO ACID METABOLISM; DNA SYNTHESIS; DRUG RESPONSE; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG TARGETING; FOLATE METABOLISM; GENE ACTIVATION; GENE EXPRESSION; HUMAN; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; PURINE METABOLISM; REVIEW; UPREGULATION;

BIOLOGICAL TRANSPORT; FOLIC ACID; FOLIC ACID ANTAGONISTS; GLYCINE; HUMANS; METHOTREXATE; MITOCHONDRIA; NEOPLASMS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SERINE; TRANSCRIPTOME;

EID: 84872519282     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3709     Document Type: Review

References (18)

1. Cole PD, Bertino JR, Kamen BA. Folate antagonists. In: Kufe DW, Bast RC Jr, Hait WN, Hong WK, Pollock RE, Weichselbaum et al., editors. Cancer medicine 7. Hamilton, Ontario, Canada: Decker; 2008. p. 648-60.
2. Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 2012;336: 1040-4.
3. Pike ST, Rajendra R, Artzt K, Appling DR. Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flowof mitochondrial onecarbon units into the methyl cycle in embryos. J Biol Chem 2010; 285: 4612-20.
4. Selcuklu SD, Donoghue MT, Rehmet K, de Souza Gomes M, Fort A, Kovvuru P, et al. MicroRNA-9 Inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cells. J Biol Chem 2012;287: 29516-28.
5. Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 2012;148: 259-72.
6. Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, et al. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 2004;5: 341-51.
7. Motokawa Y, Kikuchi G. Glycine metabolism in rat liver mitochondria. V. Intramitochondrial localization of the reversible glycine cleavage system and serine hydroxymethyltransferase. Arch Biochem Biophys 1971;146: 461-4.
8. Bester AC, Roniger M, Oren YS, Im MM, Sarni D, Chaoat M, et al. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell 2011;145: 435-46.
9. Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 2012;483: 570-5.
10. Chabner BA, Allegra CJ, Curt GA, Clendeninn NJ, Baram J, Koizumi S, et al. Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest 1985;76: 907-12
11. Sorich MJ, Pottier N, Pei D, Yang W, Kager L, Stocco G, et al. In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile. PLoS Med 2008;5: e83.
12. Zeller KI, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol 2003; 4:R69.
13. Vazquez A, Markert EK, Oltvai ZN. Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS ONE 2011;6:e25881.
14. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40: 499-507.
15. Yustein JT, Dang CV. Biology and treatment of Burkitt's lymphoma. Curr Opin Hematol 2007;14: 375-81.
16. Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TF, et al. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med 2006;354: 2419-30.
17. Markert EK, Levine AJ, Vazquez A. Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis 2012;3: e397.
18. Hatzis C, Pusztai L, Valero V, Booser DJ, Esserman L, Lluch A, et al. A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. JAMA 2011;305: 1873-81.