Higher Maternal Plasma n-3 PUFA and Lower n-6 PUFA Concentrations in Pregnancy Are Associated with Lower Childhood Systolic Blood Pressure1-3

Journal of Nutrition

Volumn 145, Issue 10, 2015, Pages 2362-2368

  Vidakovic, Aleksandra Jelena ^a   Gishti, Olta ^a   Steenweg de Graaff, Jolien ^a   Williams, Michelle A ^b   Duijts, Liesbeth ^a   Felix, Janine F ^a   Hofman, Albert ^a   Tiemeier, Henning ^a   Jaddoe, Vincent W V ^a   Gaillard, Romy ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Blood pressure; Childhood; Cohort; Pregnancy; PUFAs

Indexed keywords

DOCOSAHEXAENOIC ACID; GLYCEROPHOSPHOLIPID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPID;

ADULT; ARTICLE; CHILD; COHORT ANALYSIS; DIASTOLIC BLOOD PRESSURE; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; MALE; MATERNAL PLASMA; MOTHER; PREGNANCY; PROSPECTIVE STUDY; SECOND TRIMESTER PREGNANCY; SYSTOLIC BLOOD PRESSURE; BLOOD; BLOOD PRESSURE; CHEMISTRY; FETUS DEVELOPMENT; MATERNAL NUTRITION; NETHERLANDS; PREHYPERTENSION; PRESCHOOL CHILD; STATISTICAL MODEL;

BLOOD PRESSURE; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; FETAL DEVELOPMENT; HUMANS; LINEAR MODELS; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; NETHERLANDS; PHOSPHOLIPIDS; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PREHYPERTENSION; PROSPECTIVE STUDIES;

EID: 84945209070     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.210823     Document Type: Article

References (42)

1. Barker DJ. Fetal origins of coronary heart disease. BMJ 1995;311:171-4.
2. Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol 2001;185:93-8.
3. Szajewska H, Horvath A, Koletzko B. Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2006;83:1337-44.
4. Cetin I, Koletzko B. Long-chain omega-3 fatty acid supply in pregnancy and lactation. Curr Opin Clin Nutr Metab Care 2008;11:297-302.
5. Koletzko B, Agostoni C, Carlson SE, Clandinin T, Hornstra G, Neuringer M, Uauy R, Yamashiro Y, Willatts P. Long chain polyunsaturated fatty acids (LC-PUFA) and perinatal development. Acta Paediatr 2001;90:460-4.
6. Armitage JA, Pearce AD, Sinclair AJ, Vingrys AJ, Weisinger RS, Weisinger HS. Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency. Lipids 2003;38:459-64.
7. McFadyen M, Farquharson J, Cockburn F. Maternal and umbilical cord erythrocyte omega-3 and omega-6 fatty acids and haemorheology in singleton and twin pregnancies. Arch Dis Child Fetal Neonatal Ed 2003;88:F134-8.
8. Mahomed K, Williams MA, King IB, Mudzamiri S, Woelk GB. Erythrocyte omega-3, omega-6 and trans fatty acids in relation to risk of preeclampsia among women delivering at Harare Maternity Hospital, Zimbabwe. Physiol Res 2007;56:37-50.
9. Moon RJ, Harvey NC, Robinson SM, Ntani G, Davies JH, Inskip HM, Godfrey KM, Dennison EM, Calder PC, Cooper C, et al. Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood. J Clin Endocrinol Metab 2013;98:299-307.
10. van Rossem L, Wijga AH, de Jongste JC, Koppelman GH, Oldenwening M, Postma DS, Abrahamse-Berkeveld M, van de Heijning B, Brunekreef B, Smit HA. Blood pressure in 12-year-old children is associated with fatty acid composition of human milk: the prevention and incidence of asthma and mite allergy birth cohort. Hypertension 2012;60:1055-60.
11. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, et al. The Generation R Study: design and cohort update Eur J Epidemiol 2012;27:739-56.
12. Glaser C, Demmelmair H, Koletzko B. High-throughput analysis of fatty acid composition of plasma glycerophospholipids. J Lipid Res 2010;51:216-21.
13. Donahue SM, Rifas-Shiman SL, Gold DR, Jouni ZE, Gillman MW, Oken E. Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort. Am J Clin Nutr 2011;93:780-8.
14. Koletzko B, Lien E, Agostoni C, Bohles H, Campoy C, Cetin I, Decsi T, Dudenhausen JW, Dupont C, Forsyth S, et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 2008;36:5-14.
15. Kinsella JE, Lokesh B, Stone RA. Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms. Am J Clin Nutr 1990;52:1-28.
16. de Groot RH, Hornstra G, van Houwelingen AC, Roumen F. Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. Am J Clin Nutr 2004;79:251-60.
17. Jaddoe VW, Bakker R, van Duijn CM, van der Heijden AJ, Lindemans J, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, et al. The Generation R Study Biobank: a resource for epidemiological studies in children and their parents. Eur J Epidemiol 2007;22:917-23.
18. Wong SN, Tz Sung RY, Leung LC. Validation of three oscillometric blood pressure devices against auscultatory mercury sphygmomanometer in children. Blood Press Monit 2006;11:281-91.
19. Heppe DH, Medina-Gomez C, Hofman A, Franco OH, Rivadeneira F, Jaddoe VW. Maternal first-trimester diet and childhood bone mass: the Generation R Study. Am J Clin Nutr 2013;98:224-32.
20. Verburg BO, Steegers EA, De Ridder M, Snijders RJ, Smith E, Hofman A, Moll HA, Jaddoe VW, Witteman JC. New charts for ultrasound dating of pregnancy and assessment of fetal growth: longitudinal data from a population-based cohort study. Ultrasound Obstet Gynecol 2008;31:388-96.
21. Niklasson A, Ericson A, Fryer JG, Karlberg J, Lawrence C, Karlberg P. An update of the Swedish reference standards for weight, length and head circumference at birth for given gestational age (1977-1981). Acta Paediatr Scand 1991;80:756-62.
22. Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Twin Res 2001;4:293-8.
23. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008;359:61-73.
24. Hauner H, Much D, Vollhardt C, Brunner S, Schmid D, Sedlmeier EM, Heimberg E, Schuster T, Zimmermann A, Schneider KT, et al. Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr 2012;95: 383-94.
25. Weisinger HS, Armitage JA, Sinclair AJ, Vingrys AJ, Burns PL, Weisinger RS. Perinatal omega-3 fatty acid deficiency affects blood pressure later in life. Nat Med 2001;7:258-9.
26. Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 2011;58:2047-67.
27. Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 2002;20:1493-9.
28. Forsyth JS, Willatts P, Agostoni C, Bissenden J, Casaer P, Boehm G. Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial. BMJ 2003;326:953.
29. Damsgaard CT, Schack-Nielsen L, Michaelsen KF, Fruekilde MB, Hels O, Lauritzen L. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants. J Nutr 2006;136:94-9.
30. Hauner H, Vollhardt C, Schneider KT, Zimmermann A, Schuster T, Amann-Gassner U. The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development. Rationale and design of the INFAT study. Ann Nutr Metab 2009;54: 97-103.
31. Ciccone MM, Scicchitano P, GesualdoM, Zito A, Carbonara S, Ricci G, Cortese F, Giordano P. The role of omega-3 polyunsaturated fatty acids supplementation in childhood: a review. Recent Pat Cardiovasc Drug Discov 2013;8:42-55.
32. Ailhaud G, Guesnet P. Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion. Obes Rev 2004;5:21-6.
33. Farvid MS, Ding M, Pan A, Sun Q, Chiuve SE, Steffen LM, Willett WC, Hu FB. Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. Circulation 2014;130:1568-78.
34. Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 1993;88:523-33.
35. Cicero AF, Ertek S, Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr Vasc Pharmacol 2009;7:330-7.
36. Harris WS, Shearer GC. Omega-6 fatty acids and cardiovascular disease: friend or foe? Circulation 2014;130:1562-4.
37. Liou YA, King DJ, Zibrik D, Innis SM. Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. J Nutr 2007;137: 945-52.
38. Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated fatty acids. J Nutr Metab 2012;2012:539426.
39. Serhan CN, Clish CB, Brannon J, Colgan SP, Gronert K, Chiang N. Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. J Physiol Pharmacol 2000;51:643-54.
40. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002;56:365-79.
41. Harris WS. The omega-6/omega-3 ratio and cardiovascular disease risk: uses and abuses. Curr Atheroscler Rep 2006;8:453-9.
42. Hornstra G. Essential fatty acids in mothers and their neonates. Am J Clin Nutr 2000; 71(5, Suppl)1262S-9S.