CRISPR/Cas9-mediated rapid generation of multiple mouse lines identified Ccdc63 as essential for spermiogenesis

International Journal of Molecular Sciences

Volumn 16, Issue 10, 2015, Pages 24732-24750

  Young, Samantha A M ^a,b   Miyata, Haruhiko ^b   Satouh, Yuhkoh ^b   Kato, Hirotaka ^b,c   Nozawa, Kaori ^b,c   Isotani, Ayako ^d   Aitken, R John ^a   Baker, Mark A ^a   Ikawa, Masahito ^b,c,d  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Genome editing; Sperm motility; Spermatogenesis; Targeted mutagenesis

Indexed keywords

ALANINE; AMINO ACID; CCDC63 PROTEIN; COMPLEMENTARY DNA; CRISPR ASSOCIATED PROTEIN; DNA POLYMERASE; DYNEIN ADENOSINE TRIPHOSPHATASE; DYNEIN AXONEMAL INTERMEDIATE CHAIN 1; OLIGONUCLEOTIDE; SERINE; UNCLASSIFIED DRUG; WD REPEAT DOMAIN CONTAINING 63 PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; FERTILIZATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENOTYPE; INTRACYTOPLASMIC SPERM INJECTION; MALE; MALE FERTILITY; MOUSE; NONHUMAN; OOCYTE; PHENOTYPE; PHOSPHORYLATION; PLASMID; POINT MUTATION; PREGNANCY RATE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPERMATOGENESIS; SPERMATOZOON MOTILITY; TESTIS FUNCTION; ANIMAL; CRISPR CAS SYSTEM; GENETICS; PHYSIOLOGY;

ANIMALS; CRISPR-CAS SYSTEMS; MALE; MICE; SPERM MOTILITY; SPERMATOGENESIS;

EID: 84945208702     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms161024732     Document Type: Article

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