Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

Molecular Brain

Volumn 8, Issue 1, 2015, Pages

  Motolese, Marta ^a   Mastroiacovo, Federica ^a   Cannella, Milena ^a   Bucci, Domenico ^a   Gaglione, Anderson ^a   Riozzi, Barbara ^a   Lütjens, Robert ^b   Poli, Sonia M ^b   Celanire, Sylvain ^b,d   Bruno, Valeria ^a,c   Battaglia, Giuseppe ^a   Nicoletti, Ferdinando ^a,c  

^a IRCCS NEUROMED   (Italy)

^b Addex Therapeutics Plan les Ouates Switzerland   (Switzerland)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d Pragma Therapeutics France   (France)

Author keywords

ADX92639; Epigenetics; Global ischemia; mGlu2 receptors; Neuronal vulnerability

Indexed keywords

HISTONE DEACETYLASE 2; HISTONE H3; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5; HISTONE; LIGAND; METABOTROPIC RECEPTOR; N-(4-(2-METHOXYPHENOXY)PHENYL)-N-(2,2,2-TRIFLUOROETHYLSULFONYL)PYRID-3-YLMETHYLAMINE; PYRIDINE DERIVATIVE; SULFONAMIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL VIABILITY; CONTROLLED STUDY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HISTONE ACETYLATION; IN VITRO STUDY; MALE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; UPREGULATION; ACETYLATION; ALLOSTERISM; ANIMAL; BODY TEMPERATURE; CELL DEATH; DOWN REGULATION; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETICS; HIPPOCAMPUS; METABOLISM; MOLECULARLY TARGETED THERAPY; NERVE CELL; PATHOLOGY; PROMOTER REGION; SPRAGUE DAWLEY RAT; TIME FACTOR;

ACETYLATION; ALLOSTERIC REGULATION; ANIMALS; BODY TEMPERATURE; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; CELL DEATH; DOWN-REGULATION; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; HIPPOCAMPUS; HISTONE DEACETYLASE 2; HISTONES; LIGANDS; MALE; MOLECULAR TARGETED THERAPY; NEURONS; NEUROPROTECTION; PROMOTER REGIONS, GENETIC; PYRIDINES; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SULFONAMIDES; TIME FACTORS; UP-REGULATION;

EID: 84945126888     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/s13041-015-0158-2     Document Type: Article

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