Phosphorylation of serine 402 regulates RacGAP protein activity of FilGAP protein

Journal of Biological Chemistry

Volumn 290, Issue 43, 2015, Pages 26328-26338

  Morishita, Yuji ^a   Tsutsumi, Koji ^a   Ohta, Yasutaka ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CYTOLOGY; PROTEINS;

ACTIN FILAMENT; CELLULAR FUNCTION; DEPHOSPHORYLATIONS; GTPASE-ACTIVATING PROTEIN; MEMBRANE BLEBBING; PHOSPHATASE INHIBITORS; PHOSPHORYLATION SITES; PROTEIN ACTIVITY;

PHOSPHORYLATION;

ALANINE; CALYCULIN A; FIBRONECTIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN FILGAP; SERINE; SERINE 402; UNCLASSIFIED DRUG; VINCULIN; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ADP-RIBOSYLATION FACTOR 6; ARHGAP24 PROTEIN, HUMAN;

ACTIN FILAMENT; ARTICLE; CELL SPREADING; CELLULAR DISTRIBUTION; CELLULAR PARAMETERS; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE BLEBBING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; ANIMAL; CELL FRACTIONATION; CELL LINE; CHEMISTRY; CYTOPLASM; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE;

ADP-RIBOSYLATION FACTORS; ANIMALS; CELL LINE; CYTOPLASM; GTPASE-ACTIVATING PROTEINS; HUMANS; PHOSPHORYLATION; RNA INTERFERENCE; SERINE; SUBCELLULAR FRACTIONS;

EID: 84944937872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.666875     Document Type: Article

References (36)

1. Burridge, K., and Wennerberg, K. (2004) Rho and Rac take center stage. Cell 116, 167-179
2. Jaffe, A. B., and Hall, A. (2005) Rho GTPases: Biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269
3. Heasman, S. J., and Ridley, A. J. (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 9, 690-701
4. Parsons, J. T., Horwitz, A. R., and Schwartz, M. A. (2010) Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat. Rev. Mol. Cell Biol. 11, 633-643
5. Hall, A. (2012) Rho family GTPases. Biochem. Soc. Trans. 40, 1378-1382
6. Sadok, A., and Marshall, C. J. (2014) Rho GTPases: masters of cell migration. Small GTPases 5, e29710
7. Bos, J. L., Rehmann, H., and Wittinghofer, A. (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865-877
8. McCormack, J., Welsh, N. J., and Braga, V. M. (2013) Cycling around cell-cell adhesion with Rho GTPase regulators. J. Cell Sci. 126, 379-391
9. Miller, N. L., Kleinschmidt, E. G., and Schlaepfer, D. D. (2014) RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase. Curr. Mol. Med. 14, 221-234
10. Cook, D. R., Rossman, K. L., and Der, C. J. (2014) Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 33, 4021-4035
11. van Buul, J. D., Geerts, D., and Huveneers, S. (2014) Rho GAPs and GEFs: controling switches in endothelial cell adhesion. Cell Adh. Migr. 8, 108-124
12. Ohta, Y., Hartwig, J. H., and Stossel, T. P. (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat. Cell Biol. 8, 803-814
13. Nakamura, F., Osborn, T. M., Hartemink, C. A., Hartwig, J. H., and Stossel, T. P. (2007) Structural basis of filamin A functions. J. Cell Biol. 179, 1011-1025
14. Shifrin, Y., Arora, P. D., Ohta, Y., Calderwood, D. A., and McCulloch, C. A. (2009) The role of FilGAP-filamin A interactions in mechanoprotection. Mol. Biol. Cell 20, 1269-1279
15. Nakamura, F., Heikkinen, O., Pentikäinen, O. T., Osborn, T. M., Kasza, K. E., Weitz, D. A., Kupiainen, O., Permi, P., Kilpeläinen, I., Ylänne, J., Hartwig, J. H., and Stossel, T. P. (2009) Molecular basis of filamin AFilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS ONE 4, e4928
16. Nieves, B., Jones, C. W., Ward, R., Ohta, Y., Reverte, C. G., and LaFlamme, S. E. (2010) The NPIY motif in the integrin beta 1 tail dictates the requirement for talin-1 in outside-in signaling. J. Cell Sci. 123, 1216-1226
17. Ehrlicher, A. J., Nakamura, F., Hartwig, J. H., Weitz, D. A., and Stossel, T. P. (2011) Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature 478, 260-263
18. Saito, K., Ozawa, Y., Hibino, K., and Ohta, Y. (2012) FilGAP, a Rho/Rhoassociated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration. Mol. Biol. Cell 23, 4739-4750
19. Nakamura, F. (2013) FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration. Biochem. J. 453, 17-25
20. Kawaguchi, K., Saito, K., Asami, H., and Ohta, Y. (2014) ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing. J. Biol. Chem. 289, 9675-9682
21. Guilluy, C., Garcia-Mata, R., and Burridge, K. (2011) Rho protein crosstalk: another social network? Trends Cell Biol. 21, 718-726
22. Petrie, R. J., and Yamada, K. M. (2012) At the leading edge of three-dimensional cell migration. J. Cell Sci. 125, 5917-5926
23. Kinoshita, E., and Kinoshita-Kikuta, E. (2011) Improved Phos-tag SDSPAGE under neutral pH conditions for advanced protein phosphorylation profiling. Proteomics 11, 319-323
24. Kinoshita-Kikuta, E., Aoki, Y., Kinoshita, E., and Koike, T. (2007) Labelfree kinase profiling using phosphate affinity polyacrylamide gel electrophoresis. Mol. Cell. Proteomics 6, 356-366
25. Riento, K., and Ridley, A. (2003) ROCKS: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 4, 446-456
26. Huang, C., Jacobson, K., and Schaller, M. (2004) MAP kinases and cell migration. J. Cell Sci. 117, 4619-4628
27. Etienne-Manneville, S., and Hall, A. (2003) Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756
28. Tomar, A., and Schlaepfer, D. D. (2009) Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr. Opin. Cell Biol. 21, 676-683
29. Huveneers, S., and Danen, E. H. (2009) Adhesion signaling: crosstalk between integrins, Src and Rho. J. Cell Sci. 122, 1059-1069
30. Wolfenson, H., Lavelin, I., and Geiger, B. (2013) Dynamic regulation of the structure and functions of integrin adhesions. Dev. Cell 24, 447-458
31. Winograd-Katz, S. E., Fässler, R., Geiger, B., and Legate, K. R. (2014) The integrin adhesome: from genes and proteins to human disease. Nat. Rev. Mol. Cell Biol. 15, 273-288
32. Lawson, C. D., and Burridge, K. (2014) The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration. Small GTPases 5, e27958
33. Bianchi, M., De Lucchini, S., Marin, O., Turner, D. L., Hanks, S. K., and Villa-Moruzzi, E. (2005) Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem. J. 391, 359-370
34. Kiely, P. A., O'Gorman, D., Luong, K., Ron, D., and O'Connor, R. (2006) Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol. Cell. Biol. 26, 4041-4051
35. Kong, M., Bui, T. V., Ditsworth, D., Gruber, J. J., Goncharov, D., Krymskaya, V. P., Lindsten, T., and Thompson, C. B. (2007) The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration. J. Biol. Chem. 282, 29712-29720
36. Hall, E. H., Daugherty, A. E., Choi, C. K., Horwitz, A. F., and Brautigan, D. L. (2009) Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J. Biol. Chem. 284, 34713-34722