Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

Cell Cycle

Volumn 14, Issue 19, 2015, Pages 3066-3078

  Chiker, Sara ^a,b,c   Pennaneach, Vincent ^a,b   Loew, Damarys ^a   Dingli, Florent ^a   Biard, Denis ^d   Cordelières, Fabrice P ^a,e,f   Gemble, Simon ^a,e   Vacher, Sophie ^a   Bieche, Ivan ^a   Hall, Janet ^a,b,e   Fernet, Marie ^a,b  

^a INSTITUT CURIE   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^e CNRS   (France)

^f UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Cdk5; Hydroxyurea; Ionizing radiation; PARP 1; Replication stress

Indexed keywords

CYCLIN DEPENDENT KINASE 5; FLUOROURACIL; HISTONE H2AX; HYDROXYUREA; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN A; RAD51 PROTEIN; REPLICATING PROTEIN A SUBUNIT 32; TIOGUANINE; UNCLASSIFIED DRUG; CDK5 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PARP1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER SURVIVAL; CELL CYCLE S PHASE; CELL GROWTH; CELL KILLING; CELL PROLIFERATION; CELL STRESS; CELL SURVIVAL; COLONY FORMATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE CHECKPOINT; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; FEMALE; GAMMA IRRADIATION; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; METAPHASE; METASTASIS FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; SISTER CHROMATID EXCHANGE; BREAST TUMOR; DNA DAMAGE; DRUG EFFECTS; GENETICS; IONIZING RADIATION; METABOLISM; PHOSPHORYLATION; RADIATION RESPONSE; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 5; DNA DAMAGE; DNA REPLICATION; FEMALE; HELA CELLS; HUMANS; HYDROXYUREA; PHOSPHORYLATION; POLY (ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE) POLYMERASES; RADIATION, IONIZING;

EID: 84944909449     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1078020     Document Type: Article

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