The role and regulation of Moraxella catarrhalis-induced human beta-defensin 3 expression in human pulmonary epithelial cells

Biochemical and Biophysical Research Communications

Volumn 467, Issue 1, 2015, Pages 46-52

  Haarmann, Helge ^a,b   Steiner, Tamara ^b,c   Schreiber, Frauke ^d   Heinrich, Annina ^d   Zweigner, Janine ^e   N'Guessan, Philippe Dje ^f   Slevogt, Hortense ^d  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Neurological Rehabilitation Center for Children and Adolescents Helios Klinikum Hohenstücken   (Germany)

^d JENA UNIVERSITY HOSPITAL   (Germany)

^e UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^f Red Cross Hospital   (Germany)

Author keywords

Antimicrobial peptides; Chronic obstructive pulmonary disease; Human beta defensin 3; Moraxella catarrhalis; Pulmonary epithelial cells; Toll like receptor 2

Indexed keywords

BETA DEFENSIN 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOOLIGOSACCHARIDE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; USPA1 PROTEIN; USPA2 PROTEIN; BETA DEFENSIN; BETA-DEFENSIN 3, HUMAN; LIPID-LINKED OLIGOSACCHARIDES; LIPOPOLYSACCHARIDE; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LUNG ALVEOLUS EPITHELIUM; MORAXELLA CATARRHALIS; MORAXELLACEAE INFECTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SECRETION; RESPIRATORY TRACT INFECTION; RNA INTERFERENCE; WESTERN BLOTTING; CELL LINE; COMPLICATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY TRACT MUCOSA; SIGNAL TRANSDUCTION;

BETA-DEFENSINS; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; LIPOPOLYSACCHARIDES; LUNG; MAP KINASE SIGNALING SYSTEM; MORAXELLA (BRANHAMELLA) CATARRHALIS; MORAXELLACEAE INFECTIONS; NF-KAPPA B; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP-1;

EID: 84944896759     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.09.126     Document Type: Article

References (33)

1. WHO, World Health Organization. Chronic obstructive pulmonary disease (COPD). http://www.who.int/respiratory/copd/en (accessed 20 Aug 2015).
2. From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2015 Available from: http://www.goldcopd.org/ (accessed 20 Aug 2015)
3. S. Sethi, and T.F. Murphy Infection in the pathogenesis and course of chronic obstructive pulmonary disease N. Engl. J. Med. 359 22 2008 2355 2365
4. T.F. Murphy, and et al. Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response Am. J. Respir. Crit. Care Med. 172 2 2005 195 199
5. Y. Lai, and R.L. Gallo AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense Trends Immunol. 30 3 2009 131 141
6. M. Pazgier, and et al. Human beta-defensins Cell. Mol. Life Sci. 63 11 2006 1294 1313
7. S. Scharf, and et al. Legionella pneumophila induces human beta defensin-3 in pulmonary cells Respir. Res. 11 2010 93
8. H. Slevogt, and et al. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response Cell. Microbiol. 9 3 2007 694 707
9. H. Slevogt, and et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction Am. J. Physiol. Lung Cell Mol. Physiol. 290 5 2006 L818 L826
10. P.D. N'Guessan, and et al. The Moraxella catarrhalis-induced pro-inflammatory immune response is enhanced by the activation of the epidermal growth factor receptor in human pulmonary epithelial cells Biochem. Biophys. Res. Commun. 450 2 2014 1038 1044
11. D. Hoban, and D. Felmingham The PROTEKT surveillance study: antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections J. Antimicrob.Chemother. 50 Suppl S1 2002 49 59
12. H. Ishimoto, and et al. Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia Eur. Respir. J. 27 2 2006 253 260
13. H. Xie, and X.X. Gu Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naive monocytes to produce TNF-alpha through cellular cross-talk Cell Microbiol. 10 7 2008 1453 1467
14. H. Slevogt, and et al. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory response Cell Microbiol. 9 3 2007 694 707
15. A. Banerjee, and S. Gerondakis Coordinating TLR-activated signaling pathways in cells of the immune system Immunol. Cell Biol. 85 6 2007 420 424
16. H. Slevogt, and et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction Am. J. Physiol. Lung Cell. Mol. Physiol. 290 5 2006 L818 L826
17. H.P. Jia, and et al. Discovery of new human beta-defensins using a genomics-based approach Gene 263 1-2 2001 211 218
18. Z. Feng, and et al. Human beta-defensins: differential activity against candidal species and regulation by Candida albicans J. Dent. Res. 84 5 2005 445 450
19. G. Maisetta, and et al. In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains Antimicrob. Agents Chemother. 50 2 2006 806 809
20. M.E. Quinones-Mateu, and et al. Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication AIDS 17 16 2003 F39 F48
21. E. Leikina, and et al. Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins Nat. Immunol. 6 10 2005 995 1001
22. K.A. Brogden Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3 3 2005 238 250
23. A. Bohling, and et al. Lipid-specific membrane activity of human beta-defensin-3 Biochemistry 45 17 2006 5663 5670
24. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat. Immunol. 11 5 2010 373 384
25. S. Scharf, and et al. Streptococcus pneumoniae induces human beta-defensin-2 and -3 in human lung epithelium Exp. Lung Res. 38 2 2012 100 110
26. B.E. Menzies, and A. Kenoyer Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes Infect. Immun. 74 12 2006 6847 6854
27. D. Moranta, and et al. Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells Infect. Immun. 78 3 2010 1135 1146
28. P.K. Boughan, and et al. Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection J. Biol. Chem. 281 17 2006 11637 11648
29. C. Albanesi, and et al. IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3 J. Immunol. 179 2 2007 984 992
30. H. Slevogt, and et al. Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms Eur. Respir. J. 31 4 2008 725 735
31. N. Steubesand, and et al. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis BMC Immunol. 10 2009 36
32. C. Herr, and et al. Suppression of pulmonary innate host defence in smokers Thorax 64 2 2009 144 149
33. E. Pace, and et al. Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients PLoS One 7 3 2012 e33601