Identification of hBD-3 in respiratory tract and serum: The increase in pneumonia

European Respiratory Journal

Volumn 27, Issue 2, 2006, Pages 253-260

  Ishimoto, H ^a   Mukae, H ^a   Date, Y ^b   Shimbara, T ^b   Mondal, M S ^b   Ashitani, J ^b   Hiratsuka, T ^c   Kubo, S ^d   Kohno, S ^a   Nakazato, M ^b  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c National Hospital Organization   (Japan)

^d Peptide Institute Inc   (Japan)

Author keywords

Defensin; Immunohistochemistry; Pneumonia; Radioimmunoassay; Respiratory tract

Indexed keywords

BETA DEFENSIN 3; MESSENGER RNA;

ADULT; AGED; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL PNEUMONIA; BRONCHIOLE; BRONCHUS MUCOSA; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; MALE; PATHOPHYSIOLOGY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADULT; AGED; BETA-DEFENSINS; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; PNEUMONIA; RADIOIMMUNOASSAY; RESPIRATORY SYSTEM;

EID: 31844433263     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.06.00105904     Document Type: Article

References (29)

1. Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res 2000; 1: 141-150.
2. Harder J, Bartels J, Christophers E, Schröder JM. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001; 276: 5707-5713.
3. García JR, Jaumann F, Schulz S, et al. Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res 2001; 306: 257-264.
4. Ganz T, Selsted ME, Szklarek D, et al. Defensins, natural peptide antibiotics of human neutrophils. J Clin Invest 1985; 76: 1427-1435.
5. Selsted ME, Harwig SSL, Ganz T, Schilling JW, Lehrer RI. Primary structures of three human neutrophil defensins. J Clin Invest 1985; 76: 1436-1439.
6. Zhao C, Wang I, Lehrer RI. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996; 396: 319-322.
7. Harder J, Bartels J, Christophers E, Schröder JM. A peptide antibiotic from human skin. Nature 1997; 387: 861.
8. Hiratsuka T, Nakazato M, Date Y, et al. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 1998; 249: 943-947.
9. García JR, Krause A, Schulz S, et al. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 2001; 15: 1819-1821.
10. Nishiuchi Y, Nishio H, Inui T, Bódi J, Kimura T. Combined solid-phase and solution approach for the synthesis of large peptides or proteins. J Pept Sci 2000; 6: 84-93.
11. Kubo S, Chino N, Watanabe TX, Kimura T, Sakakibara S. Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction. Pept Res 1993; 6: 66-72.
12. Takemura H, Kaku M, Kohno S, et al. Evaluation of susceptibility of gram-positive and -negative bacteria to human defensins by using radial diffusion assay. Antimicrob Agents Chemother 1996; 40: 2280-2284.
13. Harwig SS, Ganz T, Lehrer RI. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol 1994; 236: 160-172.
14. Yanagihara K, Kaneko Y, Sawai T, et al. Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection. Antimicrob Agents Chemother 2002; 46: 3288-3291.
15. Miyata A, Kangawa K, Toshimori T, Hatoh T, Matsuo H. Molecular forms of atrial natriuretic polypeptides in mammalian tissues and plasma. Biochem Biophys Res Commun 1985; 129: 248-255.
16. Bartlett JG, Breiman RF, Mandell LA, File TM Jr. The guidelines for community-acquired pneumonia in adults from the Infectious Disease Society of America. Clin Infect Dis 1998; 26: 811-838.
17. Miyata A, Mizuno K, Minamino N, Matsuo H. Regional distribution of adrenorphin in rat brain: comparative study with PH-8P. Biochem Biophys Res Commun 1984; 120: 1030-1036.
18. Shiomi K, Nakazato M, Ihi T, Kangawa K, Matsuo H, Matsukura S. Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection. Biochem Biophys Res Commun 1993; 195: 1336-1344.
19. Hiratsuka T, Nakazato M, Ihi T, et al. Structural analysis of human β-defensin-1 and its significance in urinary tract infection. Nephron 2000; 85: 34-40.
20. Taggart CC, Greene CM, Smith SG, et al. Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol 2003; 171: 931-937.
21. Bals R, Wang X, Wu Z, et al. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998; 102: 874-880.
22. Bals R, Weiner DJ, Meegalla RL, Accurso F, Wilson JM. Salt-independent abnormality of antimicrobial activity in cystic fibrosis airway surface fluid. Am J Respir Cell Mol Biol 2001; 25: 21-25.
23. Wu Z, Hoover DM, Yang D, et al. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3. Proc Natl Acad Sci USA 2003; 100: 8880-8885.
24. Hiratsuka T, Mukae H, Iiboshi H, et al. Increased concentrations of human β-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis. Thorax 2003; 58: 425-430.
25. Ashitani J, Mukae H, Hiratsuka T, Nakazato M, Kumamoto K, Matsukura S. Elevated levels of α-defensins in plasma and BAL fluid of patients with active pulmonary tuberculosis. Chest 2002; 121: 519-526.
26. Ashitani J, Mukae H, Hiratsuka T, Nakazato M, Kumamoto K, Matsukura S. Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection. Chest 2001; 119: 1131-1137.
27. Ihi T, Nakazato M, Mukae H, Matsukura S. Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections. Clin Infect Dis 1997; 25: 1134-1140.
28. Mukae H, Iiboshi H, Nakazato N, et al. Raised plasma concentrations of α-defensins in patients with idiopathic pulmonary fibrosis. Thorax 2002; 57: 623-628.
29. Ashitani J, Mukae H, Nakazato M, et al. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J 1998; 11: 104-111.