Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms

European Respiratory Journal

Volumn 31, Issue 4, 2008, Pages 725-735

  Slevogt, H ^a   Maqami, L ^a   Vardarowa, K ^a   Beermann, W ^a   Hocke, A C ^a   Eitel, J ^a   Schmeck, B ^a   Weimann, A ^a   Opitz, B ^a   Hippenstiel, S ^a   Suttorp, N ^a   N'Guessan, P D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cytokine response; Moraxella catarrhalis; Protein kinase C isoforms; Pulmonary epithelial cells; Ubiquitous surface protein A2

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MEMBRANE PROTEIN; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C THETA; SMALL INTERFERING RNA; UBIQUITOUS MEMBRANE PROTEIN A2; UNCLASSIFIED DRUG; ISOENZYME; PRKCQ PROTEIN, HUMAN; PROTEIN KINASE C;

ARTICLE; BRONCHUS MUCOSA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; MORAXELLA CATARRHALIS; MORAXELLACEAE INFECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; BRONCHUS; CELL LINE; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; PATHOGENICITY; SIGNAL TRANSDUCTION;

BRONCHI; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-8; ISOENZYMES; MORAXELLA (BRANHAMELLA) CATARRHALIS; MORAXELLACEAE INFECTIONS; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-EPSILON; SIGNAL TRANSDUCTION;

EID: 42949130136     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00103507     Document Type: Article

References (50)

1. Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol 2006; 100: 481-499.
2. Verduin CM, Hol C, Fleer A, van Dijk H, van Belkum A. Moraxella catarrhalis: from emerging to established pathogen. Clin Microbiol Rev 2002; 15: 125-144.
3. Murphy TF, Brauer AL, Grant BJ, Sethi S. Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. Am J Respir Crit Care Med 2005; 172: 195-199.
4. McMichael JC. Vaccines for Moraxella catarrhalis. Vaccine 2000; 19: Suppl. 1, S101-S107.
5. Meier PS, Troller R, Grivea IN, Syrogiannopoulos GA, Aebi C. The outer membrane proteins UspA1 and UspA2 of Moraxella catarrhalis are highly conserved in nasopharyngeal isolates from young children. Vaccine 2002; 20: 1754-1760.
6. Attia AS, Hansen EJ. A conserved tetranucleotide repeat is necessary for wild-type expression of the Moraxella catarrhalis UspA2 protein. J Bacteriol 2006; 188: 7840-7852.
7. Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003; 22: 672-688.
8. Hippenstiel S, Opitz B, Schmeck B, Suttorp N. Lung epithelium as a sentinel and effector system in pneumonia molecular mechanisms of pathogen recognition and signal transduction. Respir Res 2006; 7: 97.
9. Mukaida N. Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 2003; 284: L566-L577.
10. Richman-Eisenstat JB, Jorens PG, Hebert CA, Ueki I, Nadel JA. Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol Lung Cell Mol Physiol 1993; 264: L413-L418.
11. Di Stefano A, Capelli A, Donner CF. Role of interleukin-8 in the pathogenesis and treatment of COPD. Chest 2004; 126: 676-678.
12. Patel IS, Seemungal TAR, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax 2002; 57: 759-764.
13. Schulz C, Wolf K, Harth M, Kratzel K, Kunz-Schughart L, Pfeifer M. Expression and release of interleukin-8 by human bronchial epithelial cells from patients with chronic obstructive pulmonary disease, smokers, and neversmokers. Respiration 2003; 70: 254-261.
14. Wickremasinghe MI, Thomas LH, Friedland JS. Pulmonary epithelial cells are a source of IL-8 in the response to Mycobacterium tuberculosis: essential role of IL-1 from infected monocytes in a NF-κB-dependent network. J Immunol 1999; 163: 3936-3947.
15. Griffin BD, Moynagh PN. In vivo binding of NF-κB to the IκB β promoter is insufficient for transcriptional activation. Biochem J 2006; 400: 115-125.
16. Li Y, Flanagan PM, Tschochner H, Kornberg RD. RNA polymerase II initiation factor interactions and transcription start site selection. Science 1994; 263: 805-807.
17. Slevogt H, Schmeck B, Jonatat C, et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-κB activation and histone deacetylase activity reduction. Am J Physiol Lung Cell Mol Physiol 2006; 290: L818-L826.
18. Adcock IM, Chung KF, Caramori G, Ito K. Kinase inhibitors and airway inflammation. Eur J Pharmacol 2006; 533: 118-132.
19. Dempsey EC, Newton AC, Mochly-Rosen D, et al. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 2000; 279: L429-L438.
20. Jordan NJ, Watson ML, Yoshimura T, Westwick J. Differential effects of protein kinase C inhibitors on chemokine production in human synovial fibroblasts. Br J Pharmacol 1996; 117: 1245-1253.
21. Liu WS, Heckman CA. The sevenfold way of PKC regulation. Cell Signal 1998; 10: 529-542.
22. Clark AS, West KA, Blumberg PM, Dennis PA. Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance. Cancer Res 2003; 63: 780-786.
23. Webb BLJ, Lindsay MA, Seybold J, et al. Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level. Biochem Pharmacol 1997; 54: 199-205.
24. Woo CH, Lim JH, Kim JH. VCAM-1 upregulation via PKCδ-p38 kinase-linked cascade mediates the TNF-α-induced leukocyte adhesion and emigration in the lung airway epithelium. Am J Physiol Lung Cell Mol Physiol 2005; 288: L307-L316.
25. Slevogt H, Tiwari KN, Schmeck B, et al. Adhesion of Moraxella catarrhalis to human bronchial epithelium characterized by a novel fluorescence-based assay. Med Microbiol Immunol (Berl) 2005; 195: 73-83.
26. Slevogt H, Seybold J, Tiwari KN, et al. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response. Cell Microbiol 2007; 9: 694-707.
27. Bergmann M, Hart L, Lindsay M, Barnes PJ, Newton R. IκBα degradation and nuclear factor-κB DNA binding are insufficient for interleukin-1β and tumor necrosis factor-α-induced κB-dependent transcription. Requirement for an additional activation pathway. J Biol Chem 1998; 273: 6607-6610.
28. N'Guessan PD, Etouem MO, Schmeck B, et al. Legionella pneumophila-induced PKCα-, MAPK-, and NF-κB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 2007; 292: L267-L277.
29. Yang F, Haile DJ, Wang X, Dailey LA, Stonehuerner JG, Ghio AJ. Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung. Am J Physiol Lung Cell Mol Physiol 2005; 289: L14-L23.
30. Li YH, Martin LD, Spizz G, Adler KB. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 2001; 276: 40982-40990.
31. Aebi C, Lafontaine ER, Cope LD, et al. Phenotypic effect of isogenic uspA1 and uspA2 mutations on Moraxella catarrhalis 035E. Infect Immun 1998; 66: 3113-3119.
32. Opitz B, Vinzing M, van Laak V, et al. Legionella pneumophila induces IFN-β in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J Biol Chem 2006; 281: 36173-36179.
33. Juan-Vergara H, Peeples ME, Lockey RF, Mohapatra SS. Protein kinase C-α activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells. J Virol 2004; 78: 13717-13726.
34. Hippenstiel S, Kratz T, Krull M, Seybold J, Eichel-Streiber C, Suttorp N. Rho protein inhibition blocks protein kinase C translocation and activation. Biochem Biophys Res Commun 1998; 245: 830-834.
35. Lallena MJ, Diaz-Meco MT, Bren G, Paya CV, Moscat J. Activation of IκB kinase β by protein kinase C isoforms. Mol Cell Biol 1999; 19: 2180-2188.
36. Griffin BD, Moynagh PN. In vivo binding of NF-κB to the IκB β promoter is insufficient for transcriptional activation. Biochem J 2006; 400: 115-125.
37. Chen D, Barniak V, VanDerMeid KR, McMichael JC. The levels and bactericidal capacity of antibodies directed against the UspA1 and UspA2 outer membrane proteins of Moraxella (Branhamella) catarrhalis in adults and children. Infect Immun 1999; 67: 1310-1316.
38. Attia AS, Lafontaine ER, Latimer JL, Aebi C, Syrogiannopoulos GA, Hansen EJ. The UspA2 protein of Moraxella catarrhalis is directly involved in the expression of serum resistance. Infect Immun 2005; 73: 2400-2410.
39. Bootsma HJ, van der Heide HGJ, van de Pas S, Schouls LM, Mooi FR. Analysis of Moraxella catarrhalis by DNA typing: evidence for a distinct subpopulation associated with virulence traits. J Infect Dis 2000; 181: 1376-1387.
40. Bergmann M, Barnes PJ, Newton R. Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1β, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms. Am J Respir Cell Mol Biol 2000; 22: 582-589.
41. Newton R, Hart LA, Stevens DA, et al. Effect of dexamethasone on interleukin-1β-(IL-1β)-induced nuclear factor-kappaB (NF-βB) and βB-dependent transcription in epithelial cells. Eur J Biochem 1998; 254: 81-89.
42. Wyatt TA, Heires AJ, Sanderson SD, Floreani AA. Protein kinase C activation is required for cigarette smoke-enhanced C5a-mediated release of interleukin-8 in human bronchial epithelial cells. Am J Respir Cell Mol Biol 1999; 21: 283-288.
43. Krunkosky TM, Fischer BM, Martin LD, Jones N, Akley NJ, Adler KB. Effects of TNF-α on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression. Am J Respir Cell Mol Biol 2000; 22: 685-692.
44. Reibman J, Talbot AT, Hsu Y, et al. Regulation of expression of granulocyte-macrophage colony-stimulating factor in human bronchial epithelial cells: roles of protein kinase C and mitogen-activated protein kinases. J Immunol 2000; 165: 1618-1625.
45. Hewson CA, Edbrooke MR, Johnston SL. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol 2004; 344: 683-695.
46. Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007; 7: 281-294.
47. Deva R, Shankaranarayanan P, Ciccoli R, Nigam S. Candida albicans induces selectively transcriptional activation of cyclooxygenase-2 in HeLa Cells: pivotal roles of toll-like receptors, p38 mitogen-activated protein kinase, and NF-κB. J Immunol 2003; 171: 3047-3055.
48. Chang YJ, Wu MS, Lin JT, et al. Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-κB activation. Mol Pharmacol 2004; 66: 1465-1477.
49. Lin CH, Kuan IH, Lee HM, et al. Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear factor-κB-dependent pathway. Br J Pharmacol 2001; 134: 543-552.
50. Dempsey EC, Cool CD, Littler CM. Lung disease and PKCs. Pharmacol Res 2007; 55: 545-559.