Characterization of an additional splice acceptor site introduced into CYP4B1 in hominoidae during evolution

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Schmidt, Eva M ^a   Wiek, Constanze ^a   Parkinson, Oliver T ^b   Roellecke, Katharina ^a   Freund, Marcel ^a   Gombert, Michael ^a   Lottmann, Nadine ^a   Steward, Charles A ^c   Kramm, Christof M ^d   Yarov Yarovoy, Vladimir ^e   Rettie, Allan E ^b   Hanenberg, Helmut ^a,f,g  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 IPOMEANOL; CYTOCHROME P450 4B1; SERINE; 4-IPOMEANOL; CYTOCHROME P-450 CYP4B1; RNA SPLICING; TERPENE; UNSPECIFIC MONOOXYGENASE;

ADULT; ALTERNATIVE RNA SPLICING; APE; ARTICLE; BINDING SITE; CAG REPEAT; CONTROLLED STUDY; CYP4B1 GENE; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG METABOLISM; EMBRYO; ENZYME ACTIVITY; ENZYME STABILITY; EVOLUTION; EXON; GENE INSERTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTRON; T LYMPHOCYTE; TRANSGENE; ANIMAL; CELL DEATH; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HEP-G2 CELL LINE; MOLECULAR MODEL; RABBIT; RNA SPLICING;

ADULT; ALTERNATIVE SPLICING; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL EVOLUTION; CELL DEATH; ENZYME STABILITY; HEK293 CELLS; HEP G2 CELLS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; RABBITS; RNA SPLICE SITES; SERINE; TERPENES;

EID: 84944789916     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0137110     Document Type: Article

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