CYP4V2 in Bietti's crystalline dystrophy: Ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.h331p variant

Molecular Pharmacology

Volumn 82, Issue 4, 2012, Pages 679-686

  Nakano, Mariko ^a   Kelly, Edward J ^a   Wiek, Constanze ^b   Hanenberg, Helmut ^b,c   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 V2; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY; CELL STRAIN HEPG2; CORNEA CELL; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; ENZYME LOCALIZATION; ENZYME STABILITY; EPITHELIUM CELL; EYE DISEASE; GENE MUTATION; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; IMMUNOHISTOCHEMISTRY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; RETINA CELL; WESTERN BLOTTING;

CELL LINE; CORNEA; CORNEAL DYSTROPHIES, HEREDITARY; CYTOCHROME P-450 ENZYME SYSTEM; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HEP G2 CELLS; HUMANS; LIPID METABOLISM; MUTATION, MISSENSE; ORGAN SPECIFICITY; RECOMBINANT PROTEINS; RETINA; RETINAL DISEASES; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER;

EID: 84866882879     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.080085     Document Type: Article

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