Nanoparticle diffusion within intestinal mucus: Three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 97, Issue , 2015, Pages 230-238

  Abdulkarim, Muthanna ^a   Agulló, Nuria ^b   Cattoz, Beatrice ^c   Griffiths, Peter ^c   Bernkop Schnürch, Andreas ^d   Gómez Borros, Salvador ^b   Gumbleton, Mark ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUT QUÍMIC DE SARRIÀ   (Spain)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Diffusion; Mucus; Multiple particle tracking; Nanoparticles; Polyelectrolyte; Virus

Indexed keywords

CHITOSAN; MACROGOL; MUCIN; NANOPARTICLE; POLYELECTROLYTE; POLYGLACTIN; POLYMER; ACRYLIC ACID RESIN; CARBOPOL 940; ELECTROLYTE; LACTIC ACID; MACROGOL DERIVATIVE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ADENOVIRIDAE; ARTICLE; ATOMIC FORCE MICROSCOPY; DIFFUSION; DRUG DELIVERY SYSTEM; FLOW KINETICS; JEJUNUM; MUCUS; NONHUMAN; PARTICLE SIZE; PIG; RESPONSE SURFACE METHOD; STEREOSPECIFICITY; SURFACE CHARGE; SYNTHESIS; VIRUS CAPSID; VIRUS PARTICLE; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; SURFACE PROPERTY; TRANSPORT AT THE CELLULAR LEVEL; VIRION;

ACRYLIC RESINS; ANIMALS; BIOLOGICAL TRANSPORT; CHITOSAN; DIFFUSION; ELECTROLYTES; JEJUNUM; LACTIC ACID; MICROSCOPY, ATOMIC FORCE; MUCUS; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; RHEOLOGY; SURFACE PROPERTIES; SWINE; VIRION;

EID: 84944760970     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.01.023     Document Type: Article

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