Two rheologically different gastric mucus secretions with different putative functions

Biochimica et Biophysica Acta - General Subjects

Volumn 1674, Issue 2, 2004, Pages 131-138

  Taylor, Catherine ^a,c   Allen, Adrian ^a   Dettmar, Peter W ^b   Pearson, Jeffrey P ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b RECKITT BENCKISER   (United Kingdom)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Fuc; fucose; Gal; galactose; GalNAc; Gastric mucus; GlcNAc; Mucin; Mucus gel; n acetyl galactosamine; n acetyl glucosamine; n acetyl neuraminic acid; NeuNAc; Rheology

Indexed keywords

GLYCOPROTEIN; LECTIN; MUCIN; PEPTIDE FRAGMENT; STOMACH MUCIN;

ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW KINETICS; FLOW MEASUREMENT; GEL; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SHEAR STRESS; STOMACH MUCUS; ANIMAL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUCUS; PROTEIN BINDING; SHEAR STRENGTH; SWINE; VISCOSITY;

SUS SCROFA;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTRIC MUCIN; GELS; GLYCOPROTEINS; HUMANS; LECTINS; MUCUS; PEPTIDE FRAGMENTS; PROTEIN BINDING; RHEOLOGY; SHEAR STRENGTH; SWINE; VISCOSITY;

EID: 7044249411     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2004.06.007     Document Type: Article

References (27)

1. Allen A., Flemstrom L., Garner A., Kivilaakso E. Gastroduodenal mucosal protection. Physiological Reviews. 73:1993;823-857
2. Allen A. Gastrointestinal mucus. Forte J.G. Handbook of Physiology - The Gastrointestinal System. vol. 111.:1989;359-382 Am. Physiol. Soc
3. Ho S.B., Anway R.E., Khalil Z.M. Spatial organization of MUC5AC and MUC6 mucins within the surface mucous layer of the stomach. Gastroenterology. 118:2000;1396
4. Nordman H., Davies J.R., Carlstedt I. Mucus glycoproteins from pig gastric mucosa: different mucins are produced by the surface epithelium and the glands. Biochemical Journal. 331:1998;687-694
5. Ohara S., Ishihara K., Hotta K. Regional differences in pig gastric mucins. Comparative Biochemistry and Physiology. 106B:1993;153-158
6. Nordman H., Davies J., Herrmann A., Karlsson N., Hansson G., Carlstedt I. Mucus glycoproteins from pig gastric mucosa: identification of different mucin populations from the surface epithelium. Biochemical Journal. 326:1997;903-910
7. Taylor C., Allen A., Dettmar P.W., Pearson J.P. The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations. Biomacromolecules. 4:2003;922-927
8. Turner B.S., Bhaskar K.R., Hadzopouloucladaras M., Specian R.D., Lamont J.T. Isolation and characterization of cDNA clones encoding pig gastric mucin. Biochemical Journal. 308:1995;89-96
9. Turner B.S., Bhaskar K.R., Hadzopoulou-Cladaras M., LaMont J.T. Cysteine-rich regions of pig gastric mucin contain von Willebrand factor and cystine knot domains at the carboxyl terminal. Biochimica Et Biophysica Acta, N. Gene Structure and Expression. 1447:1999;77-92
10. Nordman H., Davies J.R., Lindell G., de Bolos C., Real F., Carlstedt I. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochemical Journal. 364:2002;191-200
11. Bell A., Allen A., Morris E., Ross-Murphy S. Functional interactions of gastric mucus glycoprotein. International Journal of Biological Macromolecules. 6:1984;309-315
12. Fogg F.J.J., Hutton D.A., Jumel K., Pearson J.P., Harding S.E., Allen A. Characterisation of pig colonic mucins. Biochemical Journal. 316:1996;937-942
13. Starkey B.J., Snary D., Allen A. Characterization of gastric mucoproteins isolated by equilibrium density-gradient centrifugation in caesium chloride. Biochemical Journal. 141:1974;633-639
14. Mantle M., Allen A. A colorimetric assay for glycoproteins based on the periodic acid/Schiff stain. Biochemical Society Transactions. 6:1978;607-609. (proceedings)
15. Bara J., Gautier R., Lependu J., Oriol R. Immunochemical characterization of mucins - polypeptide (M1) and polysaccharide (Le a and Le b) antigens. Biochemical Journal. 254:1988;185-193
16. Bara J., Decaens C., Loridonrosa B., Oriol R. Immunohistological characterization of mucin epitopes by pretreatment of gastrointestinal sections with periodic acid. Journal of Immunological Methods. 149:1992;105-113
17. Hutton D.A., Fogg F.J.J., Kubba H., Birchall J.P., Pearson J.P. Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: evidence for the expression of different mucin gene products. Glycoconjugate Journal. 15:1998;283-291
18. Hovenberg H.W., Davies J.R., Herrmann A., Linden C.J., Carlstedt I. MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions. Glycoconjugate Journal. 13:1996;839-847
19. Baldwin C.I., Todd A., Bourke S.J., Allen A., Calvert J.E. Pigeon fanciers' lung: identification of disease-associated carbohydrate epitopes on pigeon intestinal mucin. Clinical and Experimental Immunology. 117:1999;230-236
20. Ferry J.D. Viscoelastic Properties of Polymers. 1980;John Wiley and Sons, New York
21. Bell A., Sellers L., Allen A., Cunliffe W., Morris E., Ross-Murphy S. Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile, acid, ethanol and hypertonicity on mucus gel structure. Gastroenterology. 88:1985;269-280
22. Jordan N., Newton J., Pearson J., Allen A. A novel method for the visualization of the in situ mucus layer in rat and man. Clinical Science. 95:1998;97-106
23. Koidara H., Ishihara K., Hotta K., Kagoshima M., Shimada H., Ishii K. Reaction of various lectins to mucin derived from the different layers of rat gastric mucosa: comparison of enzyme-linked lectin binding assay with lectin histochemistry. Biological and Pharmaceutical Bulletin. 23:2000;1173-1179
24. Ho S.B., Roberton A.M., Shekels L.L., Lyftogt C.T., Niehans G.A., Toribara N.W. Expression cloning of gastric mucin complementary-DNA and localization of mucin gene-expression. Gastroenterology. 109:1995;735-747
25. Ota A., Katsuyama T. Alternating laminated array of 2 types of mucin in the human gastric surface mucous layer. Histochemical Journal. 24:1992;86-92
26. Allen A., Pearson J.P. The gastrointestinal adherent mucous gel barrier. Corfield A. Glycoprotein Methods and Protocols: The Mucins. vol. 125:2000;57-64 Humana Press, Totowa, NJ
27. Atuma C., Strugala V., Allen A., Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. American Journal of Physiology: Gastrointestinal and Liver Physiology. 280:2001;G922-G929