SiRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo

Journal of Controlled Release

Volumn 220, Issue , 2015, Pages 44-50

  Suzuki, Y ^a   Hyodo, K ^a   Tanaka, Y ^b   Ishihara, H ^a  

^a EISAI CO LTD   (Japan)

^b Sogo Pharmaceutical Co Ltd   (Japan)

Author keywords

Drug delivery; Gene silencing; Lipid nanoparticles; RNA therapeutics; siRNA

Indexed keywords

BIOSYNTHESIS; DRUG DELIVERY; GENES; GENETIC ENGINEERING; LIPIDS; NANOPARTICLES; PARTICLE SIZE; RNA; STABILITY; STORAGE (MATERIALS); SYNTHESIS (CHEMICAL);

COMPREHENSIVE ASSESSMENT; CRITICAL PROPERTIES; GENE SILENCING; INTRAVENOUS ADMINISTRATION; LIPID NANOPARTICLES; LONG-TERM STORAGE STABILITY; RNA THERAPEUTICS; SIRNA;

CHEMICAL STABILITY;

BLOOD CLOTTING FACTOR 7; LIPID NANOPARTICLE; LIVER PROTEIN; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; LIPID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; GENE SILENCING; IN VIVO STUDY; LIPID ANALYSIS; LIVER CELL; MOUSE; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; STORAGE; SYNTHESIS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; MALE; TIME FACTOR;

ANIMALS; GENE SILENCING; LIPIDS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NANOPARTICLES; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 84944741155     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.10.024     Document Type: Article

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