Stabilization of ostwald ripening in low molecular weight amino lipid nanoparticles for systemic delivery of siRNA Therapeutics

Molecular Pharmaceutics

Volumn 11, Issue 11, 2014, Pages 4143-4153

  Gindy, Marian E ^a   Feuston, Brad ^a   Glass, Angela ^a   Arrington, Leticia ^a   Haas, R Matthew ^a   Schariter, Joseph ^a   Stirdivant, Steven M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Drug delivery; Lipid nanoparticle; Molecular dynamics; Ostwald ripening; SiRNA

Indexed keywords

AMINO LIPID NANOPARTICLE; APOLIPOPROTEIN B; LIPID; NANOPARTICLE; PHOSPHOLIPID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AMINO ACID; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; FEMALE; GENE SILENCING; IN VIVO STUDY; LIPID COMPOSITION; MACROMOLECULE; MOLECULAR DYNAMICS; MOLECULAR STABILITY; MORPHOLOGY; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OSTWALD RIPENING; PARTICLE SIZE; PHOSPHOLIPID BILAYER; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; RAT; SHELF LIFE; SIZE EXCLUSION CHROMATOGRAPHY; STORAGE TEMPERATURE; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DELIVERY SYSTEM; GENETICS; MOLECULAR WEIGHT; SPRAGUE DAWLEY RAT; SURFACE PROPERTY;

AMINO ACIDS; ANIMALS; APOLIPOPROTEINS B; CHROMATOGRAPHY, GEL; DRUG DELIVERY SYSTEMS; FEMALE; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR WEIGHT; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; SURFACE PROPERTIES;

EID: 84927761132     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500367k     Document Type: Article

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