Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Cohen, Ami ^a   Whitfield, Timothy W ^a   Kreifeldt, Max ^a   Koebel, Pascale ^b   Kieffer, Brigitte L ^b   Contet, Candice ^a   George, Olivier ^a   Koob, George F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DYNORPHIN; PARVOVIRUS VECTOR; PRODYNORPHIN; SHORT HAIRPIN RNA; COCAINE; ENKEPHALIN; PREPROENKEPHALIN; PROTEIN PRECURSOR; SMALL INTERFERING RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DEPRESSION; ELEVATED PLUS MAZE TEST; FORCED SWIM TEST; LOCOMOTION; MALE; MOLECULAR PATHOLOGY; NONHUMAN; NUCLEUS ACCUMBENS; PRODYNORPHIN GENE; RAT; RNA INTERFERENCE; ANALYSIS OF VARIANCE; ANIMAL; DEPENDOPARVOVIRUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENE VECTOR; GENETICS; IN SITU HYBRIDIZATION; MAZE TEST; METABOLISM; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; COCAINE; DEPENDOVIRUS; DEPRESSION; ENKEPHALINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; IN SITU HYBRIDIZATION; LOCOMOTION; MAZE LEARNING; NUCLEUS ACCUMBENS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RNA, SMALL INTERFERING;

EID: 84901217949     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097216     Document Type: Article

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