메뉴 건너뛰기




Volumn 35, Issue 10, 2015, Pages 4296-4305

Κ opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake

Author keywords

Dynorphin; Escalation; Kappa opioid receptors; Methamphetamine; Nucleus accumbens; Substances of abuse

Indexed keywords

DYNORPHIN; KAPPA OPIATE RECEPTOR; METHAMPHETAMINE; NORBINALTORPHIMINE; OPIATE ANTAGONIST; PRODYNORPHIN; CENTRAL STIMULANT AGENT; ENKEPHALIN; NALTREXONE; NARCOTIC ANTAGONIST; PREPROENKEPHALIN; PROTEIN PRECURSOR;

EID: 84924439937     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1978-13.2015     Document Type: Article
Times cited : (52)

References (61)
  • 1
    • 0037269383 scopus 로고    scopus 로고
    • Distinct effects of methamphet-amine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix
    • Adams DH, Hanson GR, Keefe KA (2003) Distinct effects of methamphet-amine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. J Neurochem 84:87–93.
    • (2003) J Neurochem , vol.84 , pp. 87-93
    • Adams, D.H.1    Hanson, G.R.2    Keefe, K.A.3
  • 2
    • 0032500737 scopus 로고    scopus 로고
    • Transition from moderate to excessive drug intake: Change in hedonic set point
    • Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300.
    • (1998) Science , vol.282 , pp. 298-300
    • Ahmed, S.H.1    Koob, G.F.2
  • 4
    • 77951855896 scopus 로고    scopus 로고
    • Kinase cascades and ligand-directed signaling at the kappa opioid receptor
    • Bruchas MR, Chavkin C (2010) Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl) 210:137–147.
    • (2010) Psychopharmacology (Berl) , vol.210 , pp. 137-147
    • Bruchas, M.R.1    Chavkin, C.2
  • 5
    • 33745832645 scopus 로고    scopus 로고
    • Kappa opioid receptor activationofp38 MAPKisGRK3- and arrestin-dependent inneurons and astrocytes
    • Bruchas MR, Macey TA, Lowe JD, Chavkin C (2006) Kappa opioid receptor activationofp38 MAPKisGRK3- and arrestin-dependent inneurons and astrocytes. J Biol Chem 281:18081–18089.
    • (2006) J Biol Chem , vol.281 , pp. 18081-18089
    • Bruchas, M.R.1    Macey, T.A.2    Lowe, J.D.3    Chavkin, C.4
  • 7
    • 84906059829 scopus 로고    scopus 로고
    • Drug withdrawal conceptualized as a stressor
    • Chartoff EH, Carlezon WA Jr (2014) Drug withdrawal conceptualized as a stressor. Behav Pharmacol 25:473–492.
    • (2014) Behav Pharmacol , vol.25 , pp. 473-492
    • Chartoff, E.H.1    Carlezon, W.A.2
  • 8
    • 80054099649 scopus 로고    scopus 로고
    • Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats
    • Chartoff E, Sawyer A, Rachlin A, Potter D, Pliakas A, Carlezon WA (2012)Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuro-pharmacology 62:167–176.
    • (2012) Neuro-Pharmacology , vol.62 , pp. 167-176
    • Chartoff, E.1    Sawyer, A.2    Rachlin, A.3    Potter, D.4    Pliakas, A.5    Carlezon, W.A.6
  • 9
    • 0020029345 scopus 로고
    • Dynorphin is a specific endogenous ligand of the kappa opioid receptor
    • Chavkin C, James IF, Goldstein A (1982) Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science 215:413–415.
    • (1982) Science , vol.215 , pp. 413-415
    • Chavkin, C.1    James, I.F.2    Goldstein, A.3
  • 10
    • 0028931471 scopus 로고
    • Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum
    • Cole RL, Konradi C, Douglass J, Hyman SE (1995) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813–823.
    • (1995) Neuron , vol.14 , pp. 813-823
    • Cole, R.L.1    Konradi, C.2    Douglass, J.3    Hyman, S.E.4
  • 11
    • 0027294728 scopus 로고
    • Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum
    • Daunais JB, Roberts DC, McGinty JF (1993) Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum. Neu-roreport 4:543–546.
    • (1993) Neu-Roreport , vol.4 , pp. 543-546
    • Daunais, J.B.1    Roberts, D.C.2    McGinty, J.F.3
  • 12
  • 13
    • 0029001901 scopus 로고
    • Kappa opioid inhibition of morphine and cocaine self-administration in rats
    • Glick SD, Maisonneuve IM, Raucci J, Archer S (1995) Kappa opioid inhibition of morphine and cocaine self-administration in rats. Brain Res 681: 147–152.
    • (1995) Brain Res , vol.681 , pp. 147-152
    • Glick, S.D.1    Maisonneuve, I.M.2    Raucci, J.3    Archer, S.4
  • 14
    • 0032840227 scopus 로고    scopus 로고
    • The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum
    • Gray AM, Rawls SM, Shippenberg TS, McGinty JF (1999) The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum. J Neurochem 73:1066–1074.
    • (1999) J Neurochem , vol.73 , pp. 1066-1074
    • Gray, A.M.1    Rawls, S.M.2    Shippenberg, T.S.3    McGinty, J.F.4
  • 15
    • 78650414337 scopus 로고    scopus 로고
    • Extended access to meth-amphetamine self-administration affects sensorimotor gating in rats
    • Hadamitzky M, Markou A, Kuczenski R (2011) Extended access to meth-amphetamine self-administration affects sensorimotor gating in rats. Be-hav Brain Res 217:386–390.
    • (2011) Be-Hav Brain Res , vol.217 , pp. 386-390
    • Hadamitzky, M.1    Markou, A.2    Kuczenski, R.3
  • 16
    • 0026764510 scopus 로고
    • Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test
    • Horan P, Taylor J, Yamamura HI, Porreca F (1992) Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test. J Pharmacol Exp Ther 260:1237–1243.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 1237-1243
    • Horan, P.1    Taylor, J.2    Yamamura, H.I.3    Porreca, F.4
  • 18
    • 0029010225 scopus 로고
    • Dopamine regulation of transcription factor-target interactions in rat striatum
    • Hyman SE, Cole RL, Konradi C, Kosofsky BE (1995) Dopamine regulation of transcription factor-target interactions in rat striatum. Chem Senses 20:257–260.
    • (1995) Chem Senses , vol.20 , pp. 257-260
    • Hyman, S.E.1    Cole, R.L.2    Konradi, C.3    Kosofsky, B.E.4
  • 19
    • 1842455734 scopus 로고    scopus 로고
    • Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
    • Ito R, Robbins TW, Everitt BJ (2004) Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nat Neurosci 7:389–397.
    • (2004) Nat Neurosci , vol.7 , pp. 389-397
    • Ito, R.1    Robbins, T.W.2    Everitt, B.J.3
  • 20
    • 84873709512 scopus 로고    scopus 로고
    • A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats
    • Jang CG, Whitfield T, Schulteis G, Koob GF, Wee S (2013) A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology (Berl) 225:753–763.
    • (2013) Psychopharmacology (Berl) , vol.225 , pp. 753-763
    • Jang, C.G.1    Whitfield, T.2    Schulteis, G.3    Koob, G.F.4    Wee, S.5
  • 21
    • 0026549917 scopus 로고
    • Long term kappa-opoid receptor blockade following nor-binaltorphimine
    • Jones DN, Holtzman SG (1992) Long term kappa-opoid receptor blockade following nor-binaltorphimine. Eur J Pharmacol 215:345–348.
    • (1992) Eur J Pharmacol , vol.215 , pp. 345-348
    • Jones, D.N.1    Holtzman, S.G.2
  • 23
    • 75149118146 scopus 로고    scopus 로고
    • Dynorphin, stress, and depression
    • Knoll AT, Calezon WA Jr(2010) Dynorphin, stress, and depression. Brain Res 1314:56–73.
    • Brain Res , pp. 56-73
    • Knoll, A.T.1
  • 25
    • 0023763088 scopus 로고
    • Cellular and molecular mechanisms of drug dependence
    • Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242:715–723.
    • (1988) Science , vol.242 , pp. 715-723
    • Koob, G.F.1    Bloom, F.E.2
  • 26
    • 0035199891 scopus 로고    scopus 로고
    • Drug addiction, dysregulation of reward, and allostasis
    • Koob GF, Le Moal M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24:97–129.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 97-129
    • Koob, G.F.1    Le Moal, M.2
  • 30
    • 54549098178 scopus 로고    scopus 로고
    • Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis
    • Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF (2008) Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry 64:958–965.
    • (2008) Biol Psychiatry , vol.64 , pp. 958-965
    • Mandyam, C.D.1    Wee, S.2    Crawford, E.F.3    Eisch, A.J.4    Richardson, H.N.5    Koob, G.F.6
  • 31
    • 0033960493 scopus 로고    scopus 로고
    • Kappa opioid receptor immunoreactivity in nucleus accumbens shell and caudate-putamen is primarily associated with synaptic vesicles in axons
    • Meshul CK, McGinty JF (2000) Kappa opioid receptor immunoreactivity in nucleus accumbens shell and caudate-putamen is primarily associated with synaptic vesicles in axons. Neuroscience 96:91–99.
    • (2000) Neuroscience , vol.96 , pp. 91-99
    • Meshul, C.K.1    McGinty, J.F.2
  • 32
    • 0021876216 scopus 로고
    • Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
    • Mucha RF, Herz A (1985) Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl) 86:274–280.
    • (1985) Psychopharmacology (Berl) , vol.86 , pp. 274-280
    • Mucha, R.F.1    Herz, A.2
  • 33
    • 79957848671 scopus 로고    scopus 로고
    • Kappa-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats
    • Nealey KA, Smith AW, Davis SM, Smith DG, Walker BM (2011) Kappa-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats. Neuropharmacology 61:35–42.
    • (2011) Neuropharmacology , vol.61 , pp. 35-42
    • Nealey, K.A.1    Smith, A.W.2    Davis, S.M.3    Smith, D.G.4    Walker, B.M.5
  • 34
    • 4644365351 scopus 로고    scopus 로고
    • Molecular mechanisms of drug addiction
    • Nestler EJ (2004) Molecular mechanisms of drug addiction. Neuropharmacology 47:24–32.
    • (2004) Neuropharmacology , vol.47 , pp. 24-32
    • Nestler, E.J.1
  • 35
    • 77953220561 scopus 로고    scopus 로고
    • The dopamine D3 receptor partial agonist CJB090 and antagonist PG 01037 decrease progressive ratio responding for methamphetamine in rats with extended-access
    • Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF (2010) The dopamine D3 receptor partial agonist CJB090 and antagonist PG 01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addict Biol 15:312–323.
    • (2010) Addict Biol , vol.15 , pp. 312-323
    • Orio, L.1    Wee, S.2    Newman, A.H.3    Pulvirenti, L.4    Koob, G.F.5
  • 36
    • 78650844914 scopus 로고    scopus 로고
    • Methamphetamine self-administration produces attentional set-shifting deficits and alters prefrontal cortical neurophysiology in rats
    • Parsegian A, Glen WB Jr, Lavin A, See RE (2011) Methamphetamine self-administration produces attentional set-shifting deficits and alters prefrontal cortical neurophysiology in rats. Biol Psychiatry 69:253–259.
    • (2011) Biol Psychiatry , vol.69 , pp. 253-259
    • Parsegian, A.1    Glen, W.B.2    Lavin, A.3    See, R.E.4
  • 38
    • 0022494591 scopus 로고
    • Psychotomimesismediated by kappa opiate receptors
    • Pfeiffer A, Brantl V, Herz A, Emrich HM (1986) Psychotomimesismediated by kappa opiate receptors. Science 233:774–776.
    • (1986) Science , vol.233 , pp. 774-776
    • Pfeiffer, A.1    Brantl, V.2    Herz, A.3    Emrich, H.M.4
  • 39
    • 0035884949 scopus 로고    scopus 로고
    • Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens
    • Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA Jr (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J Neurosci 21:7397-7403.
    • (2001) J Neurosci , vol.21 , pp. 7397-7403
    • Pliakas, A.M.1    Carlson, R.R.2    Neve, R.L.3    Konradi, C.4    Nestler, E.J.5    Carlezon, W.A.6
  • 40
    • 80053562267 scopus 로고    scopus 로고
    • Repeated exposure to the K-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity
    • Potter DN, Damez-Werno D, Carlezon WA Jr, Cohen BM, Chartoff EH (2011) Repeated exposure to the K-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity. Biol Psychiatry 70:744–753.
    • (2011) Biol Psychiatry , vol.70 , pp. 744-753
    • Potter, D.N.1    Damez-Werno, D.2    Carlezon, W.A.3    Cohen, B.M.4    Chartoff, E.H.5
  • 41
    • 79951516164 scopus 로고    scopus 로고
    • Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5
    • Reichel CM, Schwendt M, McGinty JF, Olive MF, See RE (2011) Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. Neuropsychopharmacology 36:782-792.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 792
    • Reichel, C.M.1    Schwendt, M.2    McGinty, J.F.3    Olive, M.F.4    See, R.E.5
  • 42
    • 0029980944 scopus 로고    scopus 로고
    • Progressive ratio schedules in drug self-administration studies in rats: A method to evaluate reinforcing effi-ciacy
    • Richardson NR, Roberts DCS (1996) Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing effi-ciacy. J Neurosci Methods 66:1–11.
    • (1996) J Neurosci Methods , vol.66 , pp. 1-11
    • Richardson, N.R.1    Roberts, D.2
  • 43
    • 0019311630 scopus 로고
    • Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
    • Roberts DC, Koob Gf, Klonoff P, Fibiger HC (1980) Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 12:781–787.
    • (1980) Pharmacol Biochem Behav , vol.12 , pp. 781-787
    • Roberts, D.C.1    Gf, K.2    Klonoff, P.3    Fibiger, H.C.4
  • 44
    • 77649201863 scopus 로고    scopus 로고
    • Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking
    • Rocha A, Kalivas PW (2010) Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking. Eur J Neurosci 31: 903–909.
    • (2010) Eur J Neurosci , vol.31 , pp. 903-909
    • Rocha, A.1    Kalivas, P.W.2
  • 45
    • 48149097866 scopus 로고    scopus 로고
    • Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats
    • Rogers JL, De Santis S, See RE (2008) Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats. Psychopharmacology (Berl) 199:615–624.
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 615-624
    • Rogers, J.L.1    De Santis, S.2    See, R.E.3
  • 46
    • 0032982427 scopus 로고    scopus 로고
    • U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking
    • Schenk S, Partridge B, Shippenberg TS (1999) U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking. Psychopharmacology (Berl) 144:339–346.
    • (1999) Psychopharmacology (Berl) , vol.144 , pp. 339-346
    • Schenk, S.1    Partridge, B.2    Shippenberg, T.S.3
  • 49
    • 70350449261 scopus 로고    scopus 로고
    • Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion
    • Schwendt M, Rocha A, See RE, Pacchioni AM, McGinty JF, Kalivas PW (2009) Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion. J Pharmacol Exp Ther 331:555.562.
    • (2009) J Pharmacol Exp Ther , pp. 562
    • Schwendt, M.1    Rocha, A.2    See, R.E.3    Pacchioni, A.M.4    McGinty, J.F.5    Kalivas, P.W.6
  • 50
    • 34648832260 scopus 로고    scopus 로고
    • Dynorphin and the pathophys-iology of drug addiction
    • Shippenberg TS, Zapata A, Chefer VI (2007) Dynorphin and the pathophys-iology of drug addiction. Pharmacol Ther 116:306–321.
    • (2007) Pharmacol Ther , vol.116 , pp. 306-321
    • Shippenberg, T.S.1    Zapata, A.2    Chefer, V.I.3
  • 51
    • 0028942522 scopus 로고
    • Forskolin induces preproenkephalin and preprodynorphin mRNA in rat striatum as demonstrated by in situ hybridization histochemistry
    • Simpson JN, McGinty JF (1995) Forskolin induces preproenkephalin and preprodynorphin mRNA in rat striatum as demonstrated by in situ hybridization histochemistry. Synapse 19:151–159.
    • (1995) Synapse , vol.19 , pp. 151-159
    • Simpson, J.N.1    McGinty, J.F.2
  • 52
    • 0028158819 scopus 로고
    • Acute amphetamine or methamphetamine alters opioid peptide mRNA expression in rat striatum
    • Smith AJ, McGinty JF (1994) Acute amphetamine or methamphetamine alters opioid peptide mRNA expression in rat striatum. Brain Res Mol Brain Res 21:359–362.
    • (1994) Brain Res Mol Brain Res , vol.21 , pp. 359-362
    • Smith, A.J.1    McGinty, J.F.2
  • 54
    • 0033103771 scopus 로고    scopus 로고
    • Cellular sites for dynorphin activation of kappa-opioid receptors in the rat nucleus accumbens shell
    • Svingos AL, Colago EE, Pickel VM (1999) Cellular sites for dynorphin activation of kappa-opioid receptors in the rat nucleus accumbens shell. J Neurosci 19:1804–1813.
    • (1999) J Neurosci , vol.19 , pp. 1804-1813
    • Svingos, A.L.1    Colago, E.E.2    Pickel, V.M.3
  • 55
    • 78649910013 scopus 로고    scopus 로고
    • Systemic K-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    • Walker BM, Zorilla EP, Koob GF (2011) Systemic K-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addict Biol 16:116–119.
    • (2011) Addict Biol , vol.16 , pp. 116-119
    • Walker, B.M.1    Zorilla, E.P.2    Koob, G.F.3
  • 56
    • 0020377830 scopus 로고
    • Compar-ison of the distribution of dynorphin systems and enkephalin systems in brain
    • Watson SJ, Khachaturian H, Akil H, Coy DH, Goldstein A (1982) Compar-ison of the distribution of dynorphin systems and enkephalin systems in brain. Science 218:1134–1136.
    • (1982) Science , vol.218 , pp. 1134-1136
    • Watson, S.J.1    Khachaturian, H.2    Akil, H.3    Coy, D.H.4    Goldstein, A.5
  • 57
    • 77953290684 scopus 로고    scopus 로고
    • The role of the dynorphin-KOR opioid system in the reinforcing effects of drugs of abuse
    • Wee S, Koob GF (2010) The role of the dynorphin-KOR opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology 210:121– 135.
    • (2010) Psychopharmacology , pp. 135
    • Wee, S.1    Koob, G.F.2
  • 58
    • 34548671926 scopus 로고    scopus 로고
    • Effect of aripiprazole, a partial D2 receptor agonist, on increased rate of metham-phetamine self-administration in rats with prolonged access
    • Wee S, Wang Z, Woolverton WL, Pulvirenti L, Koob GF (2007) Effect of aripiprazole, a partial D2 receptor agonist, on increased rate of metham-phetamine self-administration in rats with prolonged access. Neuropsy-chopharmacology 32:2238–2247.
    • (2007) Neuropsy-Chopharmacology , vol.32 , pp. 2238-2247
    • Wee, S.1    Wang, Z.2    Woolverton, W.L.3    Pulvirenti, L.4    Koob, G.F.5
  • 59
    • 68149166916 scopus 로고    scopus 로고
    • Inhibitionofkappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine
    • Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF (2009) Inhibitionofkappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology 205:565–575.
    • (2009) Psychopharmacology , vol.205 , pp. 565-575
    • Wee, S.1    Orio, L.2    Ghirmai, S.3    Cashman, J.R.4    Koob, G.F.5
  • 60
    • 84899504633 scopus 로고    scopus 로고
    • Excessive cocaine use results from decreased phasic dopamine signaling in the stria-tum
    • Willuhn I, Burgeno LM, Groblewski PA, Phillips PE (2014) Excessive cocaine use results from decreased phasic dopamine signaling in the stria-tum. Nat Neurosci 17:704–709.
    • (2014) Nat Neurosci , vol.17 , pp. 704-709
    • Willuhn, I.1    Burgeno, L.M.2    Groblewski, P.A.3    Phillips, P.E.4
  • 61
    • 84876452130 scopus 로고    scopus 로고
    • Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats
    • Zhou Y, Leri F, Grella SL, Aldrich JV, Kreek MJ (2013) Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. Synapse 67:358–361.
    • (2013) Synapse , vol.67 , pp. 358-361
    • Zhou, Y.1    Leri, F.2    Grella, S.L.3    Aldrich, J.V.4    Kreek, M.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.