Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1023-1026

  Béguin, Cécile ^a,b   Potuzak, Justin ^a,b   Xu, Wei ^c   Liu Chen, Lee Yuan ^c   Streicher, John M ^d   Groer, Chad E ^d   Bohn, Laura M ^d   Carlezon Jr , William A ^a,b   Cohen, Bruce M ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Anxiety; Drug addiction; Kappa opioid receptor; Mood; Partial agonist; Salvinorin

Indexed keywords

12 EPI SALVINORIN A; 12 EPI SALVINORIN B; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; BETA ARRESTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; NALBUPHINE; SALVINORIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; DITERPENES, CLERODANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR CONFORMATION; RECEPTORS, OPIOID, KAPPA; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855677697     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.128     Document Type: Article

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