Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 8, 2015, Pages L821-L833

  Mishra, Anurag ^a,b   Stueckle, Todd A ^a,b   Mercer, Robert R ^a   Derk, Raymond ^a   Rojanasaku, Yon ^b   Castranova, Vincent ^b   Wang, Liying ^a,b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Carbon nanotubes; Collagen I; Fibrosis; Lung; Receptor; Transforming growth factor

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 1; F ACTIN; MULTI WALLED NANOTUBE; SINGLE WALLED NANOTUBE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; CARBON NANOTUBE; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN, HUMAN; SMALL INTERFERING RNA; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL INTERACTION; CELL STRUCTURE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM CELL; FIBROBLAST; FIBROGENESIS; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LUNG FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; GENETICS; LUNG; METABOLISM; PULMONARY FIBROSIS; RESPIRATORY MUCOSA; RISK FACTOR; ULTRASTRUCTURE;

ANIMALS; CELL LINE; COLLAGEN TYPE I; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUNG; MICE; NANOTUBES, CARBON; PROTEIN-SERINE-THREONINE KINASES; PULMONARY FIBROSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RESPIRATORY MUCOSA; RISK FACTORS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84944472833     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00002.2015     Document Type: Article

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