메뉴 건너뛰기




Volumn 10, Issue 11, 2015, Pages 1755-1785

Using the GEMM-ESC strategy to study gene function in mouse models

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; RECOMBINASE; RNA; PROTEIN;

EID: 84944407375     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2015.114     Document Type: Article
Times cited : (41)

References (60)
  • 1
    • 84878760040 scopus 로고    scopus 로고
    • Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications
    • Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190-1194 (2013).
    • (2013) Science , vol.340 , pp. 1190-1194
    • Sato, T.1    Clevers, H.2
  • 2
    • 84870569410 scopus 로고    scopus 로고
    • Three-dimensional culture of human breast epithelial cells: The how and the why
    • Vidi, P.A., Bissell, M.J. & Lelievre, S.A. Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol. Biol. 945, 193-219 (2013).
    • (2013) Methods Mol. Biol. , vol.945 , pp. 193-219
    • Vidi, P.A.1    Bissell, M.J.2    Lelievre, S.A.3
  • 3
    • 84897125705 scopus 로고    scopus 로고
    • Rethinking differentiation: Stem cells, regeneration, and plasticity
    • Sanchez Alvarado, A. & Yamanaka, S. Rethinking differentiation: stem cells, regeneration, and plasticity. Cell 157, 110-119 (2014).
    • (2014) Cell , vol.157 , pp. 110-119
    • Sanchez Alvarado, A.1    Yamanaka, S.2
  • 4
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 5
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • Frese, K.K. & Tuveson, D.A. Maximizing mouse cancer models. Nat. Rev. Cancer 7, 645-658 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 645-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 6
    • 84655164923 scopus 로고    scopus 로고
    • Experimental mouse tumour models: What can be learnt about human cancer immunology? Nat
    • Dranoff, G. Experimental mouse tumour models: what can be learnt about human cancer immunology? Nat. Rev. Immunol. 12, 61-66 (2012).
    • (2012) Rev. Immunol. , vol.12 , pp. 61-66
    • Dranoff, G.1
  • 8
    • 85006217674 scopus 로고    scopus 로고
    • CTLA-4 blockade with ipilimumab: Biology, safety, efficacy, and future considerations
    • Camacho, L.H. CTLA-4 blockade with ipilimumab: biology, safety, efficacy, and future considerations. Cancer Med. 4, 661-672 (2015).
    • (2015) Cancer Med. , vol.4 , pp. 661-672
    • Camacho, L.H.1
  • 9
    • 80051671759 scopus 로고    scopus 로고
    • Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models
    • Huijbers, I.J., Krimpenfort, P., Berns, A. & Jonkers, J. Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models. Bioessays 33, 701-710 (2011).
    • (2011) Bioessays , vol.33 , pp. 701-710
    • Huijbers, I.J.1    Krimpenfort, P.2    Berns, A.3    Jonkers, J.4
  • 10
    • 84936806860 scopus 로고    scopus 로고
    • Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
    • Henneman, L. et al. Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. Proc. Natl. Acad. Sci. USA 112, 8409-8414 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 8409-8414
    • Henneman, L.1
  • 11
    • 84893809132 scopus 로고    scopus 로고
    • Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells
    • Huijbers, I.J. et al. Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol. Med. 6, 212-225 (2014).
    • (2014) EMBO Mol. Med. , vol.6 , pp. 212-225
    • Huijbers, I.J.1
  • 12
    • 84897143633 scopus 로고    scopus 로고
    • Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons
    • Ivics, Z. et al. Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons. Nat. Protoc. 9, 794-809 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 794-809
    • Ivics, Z.1
  • 13
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1
  • 14
    • 84873734105 scopus 로고    scopus 로고
    • RNA-guided human genome engineering via Cas9
    • Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
    • (2013) Science , vol.339 , pp. 823-826
    • Mali, P.1
  • 15
    • 79551685675 scopus 로고    scopus 로고
    • A TALE nuclease architecture for efficient genome editing
    • Miller, J.C. et al. A TALE nuclease architecture for efficient genome editing. Nat. Biotechnol. 29, 143-148 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 143-148
    • Miller, J.C.1
  • 16
    • 84887010498 scopus 로고    scopus 로고
    • Genome engineering using the CRISPR-Cas9 system
    • Ran, F.A. et al. Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8, 2281-2308 (2013).
    • (2013) Nat. Protoc. , vol.8 , pp. 2281-2308
    • Ran, F.A.1
  • 18
    • 79751487297 scopus 로고    scopus 로고
    • Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
    • Zhang, F. et al. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat. Biotechnol. 29, 149-153 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 149-153
    • Zhang, F.1
  • 19
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang, H. et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918 (2013).
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1
  • 20
    • 84884289608 scopus 로고    scopus 로고
    • One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
    • Yang, H. et al. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 154, 1370-1379 (2013).
    • (2013) Cell , vol.154 , pp. 1370-1379
    • Yang, H.1
  • 21
    • 54949105021 scopus 로고    scopus 로고
    • Promotion of reprogramming to ground state pluripotency by signal inhibition
    • Silva, J. et al. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol. 6, e253 (2008).
    • (2008) PLoS Biol. , vol.6 , pp. e253
    • Silva, J.1
  • 22
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell self-renewal
    • Ying, Q.L. et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519-523 (2008).
    • (2008) Nature , vol.453 , pp. 519-523
    • Ying, Q.L.1
  • 23
    • 84895476817 scopus 로고    scopus 로고
    • Derivation and characterization of mouse embryonic stem cells from permissive and nonpermissive strains
    • Czechanski, A. et al. Derivation and characterization of mouse embryonic stem cells from permissive and nonpermissive strains. Nat. Protoc. 9, 559-574 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 559-574
    • Czechanski, A.1
  • 24
    • 67349183976 scopus 로고    scopus 로고
    • Metastable pluripotent states in NOD-mouse-derived ESCs
    • Hanna, J. et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 4, 513-524 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 513-524
    • Hanna, J.1
  • 25
    • 67650432118 scopus 로고    scopus 로고
    • Validated germline-competent embryonic stem cell lines from nonobese diabetic mice
    • Nichols, J. et al. Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat. Med. 15, 814-818 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 814-818
    • Nichols, J.1
  • 26
    • 84870279174 scopus 로고    scopus 로고
    • Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases
    • Reinholdt, L.G. et al. Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases. PLoS ONE 7, e50081 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e50081
    • Reinholdt, L.G.1
  • 27
    • 79952696452 scopus 로고    scopus 로고
    • A rapid and scalable system for studying gene function in mice using conditional RNA interference
    • Premsrirut, P.K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145-158 (2011).
    • (2011) Cell , vol.145 , pp. 145-158
    • Premsrirut, P.K.1
  • 28
    • 84891711129 scopus 로고    scopus 로고
    • A modular and flexible ESC-based mouse model of pancreatic cancer
    • Saborowski, M. et al. A modular and flexible ESC-based mouse model of pancreatic cancer. Genes Dev. 28, 85-97 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 85-97
    • Saborowski, M.1
  • 29
    • 84858439380 scopus 로고    scopus 로고
    • Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches
    • van Miltenburg, M.H. & Jonkers, J. Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches. Curr. Opin. Genet. Dev. 22, 21-27 (2012).
    • (2012) Curr. Opin. Genet. Dev. , vol.22 , pp. 21-27
    • Van Miltenburg, M.H.1    Jonkers, J.2
  • 30
    • 32344453096 scopus 로고    scopus 로고
    • Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells
    • Beard, C., Hochedlinger, K., Plath, K., Wutz, A. & Jaenisch, R. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 44, 23-28 (2006).
    • (2006) Genesis , vol.44 , pp. 23-28
    • Beard, C.1    Hochedlinger, K.2    Plath, K.3    Wutz, A.4    Jaenisch, R.5
  • 32
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
    • Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822-826 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 822-826
    • Fu, Y.1
  • 33
    • 84884165315 scopus 로고    scopus 로고
    • DNA targeting specificity of RNA-guided Cas9 nucleases
    • Hsu, P.D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 31, 827-832 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 827-832
    • Hsu, P.D.1
  • 34
    • 84884155038 scopus 로고    scopus 로고
    • High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
    • Pattanayak, V. et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat. Biotechnol. 31, 839-843 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 839-843
    • Pattanayak, V.1
  • 35
    • 84903943282 scopus 로고    scopus 로고
    • Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs
    • Smith, C. et al. Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs. Cell Stem Cell 15, 12-13 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 12-13
    • Smith, C.1
  • 36
    • 84904010334 scopus 로고    scopus 로고
    • Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing
    • Veres, A. et al. Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Cell Stem Cell 15, 27-30 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 27-30
    • Veres, A.1
  • 37
    • 84884160273 scopus 로고    scopus 로고
    • CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
    • Mali, P. et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 31, 833-838 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 833-838
    • Mali, P.1
  • 38
    • 84884288934 scopus 로고    scopus 로고
    • Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
    • Ran, F.A. et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154, 1380-1389 (2013).
    • (2013) Cell , vol.154 , pp. 1380-1389
    • Ran, F.A.1
  • 39
    • 84931281938 scopus 로고    scopus 로고
    • Reproducibility: Use mouse biobanks or lose them
    • Lloyd, K., Franklin, C., Lutz, C. & Magnuson, T. Reproducibility: use mouse biobanks or lose them. Nature 522, 151-153 (2015).
    • (2015) Nature , vol.522 , pp. 151-153
    • Lloyd, K.1    Franklin, C.2    Lutz, C.3    Magnuson, T.4
  • 40
    • 84899676123 scopus 로고    scopus 로고
    • Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice
    • Dow, L.E. et al. Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice. PLoS ONE 9, e95236 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e95236
    • Dow, L.E.1
  • 41
    • 84858382422 scopus 로고    scopus 로고
    • A pipeline for the generation of shRNA transgenic mice
    • Dow, L.E. et al. A pipeline for the generation of shRNA transgenic mice. Nat. Protoc. 7, 374-393 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 374-393
    • Dow, L.E.1
  • 42
    • 77952031756 scopus 로고    scopus 로고
    • Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability
    • Kiyonari, H., Kaneko, M., Abe, S. & Aizawa, S. Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability. Genesis 48, 317-327 (2010).
    • (2010) Genesis , vol.48 , pp. 317-327
    • Kiyonari, H.1    Kaneko, M.2    Abe, S.3    Aizawa, S.4
  • 43
    • 84892389031 scopus 로고    scopus 로고
    • A comparative study of protocols for mouse embryonic stem cell culturing
    • Tamm, C., Pijuan Galito, S. & Anneren, C. A comparative study of protocols for mouse embryonic stem cell culturing. PLoS ONE 8, e81156 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e81156
    • Tamm, C.1    Pijuan Galito, S.2    Anneren, C.3
  • 44
    • 56249134560 scopus 로고    scopus 로고
    • Extensive genomic copy number variation in embryonic stem cells
    • Liang, Q., Conte, N., Skarnes, W.C. & Bradley, A. Extensive genomic copy number variation in embryonic stem cells. Proc. Natl. Acad. Sci. USA 105, 17453-17456 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17453-17456
    • Liang, Q.1    Conte, N.2    Skarnes, W.C.3    Bradley, A.4
  • 45
    • 67649574240 scopus 로고    scopus 로고
    • Agouti C57BL/6N embryonic stem cells for mouse genetic resources
    • Pettitt, S.J. et al. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat. Methods 6, 493-495 (2009).
    • (2009) Nat. Methods , vol.6 , pp. 493-495
    • Pettitt, S.J.1
  • 46
    • 84902381059 scopus 로고    scopus 로고
    • Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer
    • Bin Ali, R. et al. Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer. Transgenic Res. 23, 691-695 (2014).
    • (2014) Transgenic Res. , vol.23 , pp. 691-695
    • Bin Ali, R.1
  • 47
    • 0026771287 scopus 로고
    • Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
    • te Riele, H., Maandag, E.R. & Berns, A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc. Natl. Acad. Sci. USA 89, 5128-5132 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5128-5132
    • Te Riele, H.1    Maandag, E.R.2    Berns, A.3
  • 48
    • 55449107738 scopus 로고    scopus 로고
    • A translational profiling approach for the molecular characterization of CNS cell types
    • Heiman, M. et al. A translational profiling approach for the molecular characterization of CNS cell types. Cell 135, 738-748 (2008).
    • (2008) Cell , vol.135 , pp. 738-748
    • Heiman, M.1
  • 49
    • 34548176271 scopus 로고    scopus 로고
    • P15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
    • Krimpenfort, P. et al. p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature 448, 943-946 (2007).
    • (2007) Nature , vol.448 , pp. 943-946
    • Krimpenfort, P.1
  • 51
    • 84875839596 scopus 로고    scopus 로고
    • Novel PCR assay for determining the genetic sex of mice
    • McFarlane, L., Truong, V., Palmer, J.S. & Wilhelm, D. Novel PCR assay for determining the genetic sex of mice. Sex. Dev. 7, 207-211 (2013).
    • (2013) Sex. Dev. , vol.7 , pp. 207-211
    • McFarlane, L.1    Truong, V.2    Palmer, J.S.3    Wilhelm, D.4
  • 53
    • 84865219405 scopus 로고    scopus 로고
    • Sequencing and characterization of the FVB/NJ mouse genome
    • Wong, K. et al. Sequencing and characterization of the FVB/NJ mouse genome. Genome Biol. 13, R72 (2012).
    • (2012) Genome Biol. , vol.13 , pp. R72
    • Wong, K.1
  • 54
    • 84867337106 scopus 로고    scopus 로고
    • Next-generation sequencing of experimental mouse strains
    • Yalcin, B., Adams, D.J., Flint, J. & Keane, T.M. Next-generation sequencing of experimental mouse strains. Mamm. Genome 23, 490-498 (2012).
    • (2012) Mamm. Genome , vol.23 , pp. 490-498
    • Yalcin, B.1    Adams, D.J.2    Flint, J.3    Keane, T.M.4
  • 55
    • 84858735651 scopus 로고    scopus 로고
    • The fine-scale architecture of structural variants in 17 mouse genomes
    • Yalcin, B. et al. The fine-scale architecture of structural variants in 17 mouse genomes. Genome Biol. 13, R18 (2012).
    • (2012) Genome Biol. , vol.13 , pp. R18
    • Yalcin, B.1
  • 56
    • 0141523025 scopus 로고    scopus 로고
    • Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
    • Meuwissen, R. et al. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 4, 181-189 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 181-189
    • Meuwissen, R.1
  • 57
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson, E.L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 3243-3248
    • Jackson, E.L.1
  • 58
    • 39849089040 scopus 로고    scopus 로고
    • A conditional mouse model for malignant mesothelioma
    • Jongsma, J. et al. A conditional mouse model for malignant mesothelioma. Cancer Cell 13, 261-271 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 261-271
    • Jongsma, J.1
  • 59
    • 34547496282 scopus 로고    scopus 로고
    • Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
    • Liu, X. et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc. Natl. Acad. Sci. USA 104, 12111-12116 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 12111-12116
    • Liu, X.1
  • 60
    • 79956108858 scopus 로고    scopus 로고
    • Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice
    • Derksen, P.W. et al. Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis. Model Mech. 4, 347-358 (2011).
    • (2011) Dis. Model Mech. , vol.4 , pp. 347-358
    • Derksen, P.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.