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Volumn 4, Issue 5, 2015, Pages 661-672

CTLA-4 blockade with ipilimumab: Biology, safety, efficacy, and future considerations

Author keywords

CTLA 4; CTLA4; Immunotherapy; Ipilimumab; Melanoma; Survival

Indexed keywords

CORTICOSTEROID; CYTOTOXIC AGENT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DABRAFENIB; DURVALUMAB; IPILIMUMAB; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; TRAMETINIB; VEMURAFENIB; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

EID: 85006217674     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.371     Document Type: Article
Times cited : (96)

References (59)
  • 2
    • 0035795581 scopus 로고    scopus 로고
    • Recent trends in cutaneous melanoma incidence among whites in the United States
    • Jemal, A., S. S. Devesa, P. Hartge, and M. A. Tucker . 2001. Recent trends in cutaneous melanoma incidence among whites in the United States. J. Natl Cancer Inst. 93:678-683.
    • (2001) J. Natl Cancer Inst. , vol.93 , pp. 678-683
    • Jemal, A.1    Devesa, S.S.2    Hartge, P.3    Tucker, M.A.4
  • 3
    • 39149104690 scopus 로고    scopus 로고
    • Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials
    • Korn, E. L., P. Y. Liu, S. J. Lee, J. A. Chapman, D. Niedzwiecki, V. J. Suman, et al. 2008. Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J. Clin. Oncol. 26:527-534.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 527-534
    • Korn, E.L.1    Liu, P.Y.2    Lee, S.J.3    Chapman, J.A.4    Niedzwiecki, D.5    Suman, V.J.6
  • 6
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild, A., J. J. Grob, L. V. Demidov, T. Jouary, R. Gutzmer, M. Millward, et al. 2012. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5    Millward, M.6
  • 9
    • 84856988252 scopus 로고    scopus 로고
    • Frequency of mutations associated with targeted therapy in malignant melanoma patients
    • abstr 8597.
    • Cheng, S., P. Chu, M. Hinshaw, K. Smith, J. Maize, and A. Sferruzza . 2011. Frequency of mutations associated with targeted therapy in malignant melanoma patients. J. Clin. Oncol. 29(Suppl.):abstr 8597.
    • (2011) J. Clin. Oncol. , vol.29
    • Cheng, S.1    Chu, P.2    Hinshaw, M.3    Smith, K.4    Maize, J.5    Sferruzza, A.6
  • 11
    • 0023820250 scopus 로고
    • A differential molecular biology search for genes preferentially expressed in functional T lymphocytes: the CTLA genes
    • Brunet, J. F., F. Denizot, and P. Golstein . 1988. A differential molecular biology search for genes preferentially expressed in functional T lymphocytes: the CTLA genes. Immunol. Rev. 103:21-36.
    • (1988) Immunol. Rev. , vol.103 , pp. 21-36
    • Brunet, J.F.1    Denizot, F.2    Golstein, P.3
  • 12
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel, M. F., and J. P. Allison . 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459-465.
    • (1995) J. Exp. Med. , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 13
    • 32644467549 scopus 로고    scopus 로고
    • Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
    • Ribas, A., L. H. Camacho, G. Lopez-Berestein, D. Pavlov, C. A. Bulanhagui, R. Millham, et al. 2005. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675, 206. J. Clin. Oncol. 23:8968-8977.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8968-8977
    • Ribas, A.1    Camacho, L.H.2    Lopez-Berestein, G.3    Pavlov, D.4    Bulanhagui, C.A.5    Millham, R.6
  • 15
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • Ribas, A., R. Kefford, M. A. Marshall, C. J. Punt, J. B. Haanen, M. Marmol, et al. 2013. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J. Clin. Oncol. 31:616-622.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3    Punt, C.J.4    Haanen, J.B.5    Marmol, M.6
  • 18
    • 78449258549 scopus 로고    scopus 로고
    • Development of ipilimumab: contribution to a new paradigm for cancer immunotherapy
    • Hoos, A., R. Ibrahim, A. Korman, K. Abdallah, D. Berman, V. Shahabi, et al. 2010. Development of ipilimumab: contribution to a new paradigm for cancer immunotherapy. Semin. Oncol. 37:533-546.
    • (2010) Semin. Oncol. , vol.37 , pp. 533-546
    • Hoos, A.1    Ibrahim, R.2    Korman, A.3    Abdallah, K.4    Berman, D.5    Shahabi, V.6
  • 19
    • 78449243489 scopus 로고    scopus 로고
    • Immune checkpoint proteins: a new therapeutic paradigm for cancer-preclinical background: CTLA-4 and PD-1 blockade
    • Weber, J. 2010. Immune checkpoint proteins: a new therapeutic paradigm for cancer-preclinical background: CTLA-4 and PD-1 blockade. Semin. Oncol. 37:430-439.
    • (2010) Semin. Oncol. , vol.37 , pp. 430-439
    • Weber, J.1
  • 20
    • 78449249018 scopus 로고    scopus 로고
    • Ipilimumab: unleashing the power of the immune system through CTLA-4 blockade
    • Boasberg, P., O. Hamid, and S. O'Day . 2010. Ipilimumab: unleashing the power of the immune system through CTLA-4 blockade. Semin. Oncol. 37:440-449.
    • (2010) Semin. Oncol. , vol.37 , pp. 440-449
    • Boasberg, P.1    Hamid, O.2    O'Day, S.3
  • 21
    • 40949116644 scopus 로고    scopus 로고
    • Novel therapies targeting the immune system: CTLA4 blockade with tremelimumab (CP-675,206), a fully human monoclonal antibody
    • Camacho, L. H. 2008. Novel therapies targeting the immune system: CTLA4 blockade with tremelimumab (CP-675, 206), a fully human monoclonal antibody. Expert Opin. Investig. Drugs 17:371-385.
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 371-385
    • Camacho, L.H.1
  • 22
    • 35148900936 scopus 로고    scopus 로고
    • Three decades of evolving treatment for melanoma: no improvement in survival?
    • abstr 7511.
    • Young, S. E., A. E. Giuliano, and D. L. Morton . 2005. Three decades of evolving treatment for melanoma: no improvement in survival? J. Clin. Oncol. 23(Suppl.):abstr 7511.
    • (2005) J. Clin. Oncol. , vol.23
    • Young, S.E.1    Giuliano, A.E.2    Morton, D.L.3
  • 23
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C., L. Thomas, I. Bondarenko, S. O'Day, J. Weber, C. Garbe, et al. 2011. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364:2517-2526.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Weber, J.5    Garbe, C.6
  • 24
    • 77955256254 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
    • O'Day, S. J., M. Maio, V. Chiarion-Sileni, T. F. Gajewski, H. Pehamberger, I. N. Bondarenko, et al. 2010. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann. Oncol. 21:1712-1717.
    • (2010) Ann. Oncol. , vol.21 , pp. 1712-1717
    • O'Day, S.J.1    Maio, M.2    Chiarion-Sileni, V.3    Gajewski, T.F.4    Pehamberger, H.5    Bondarenko, I.N.6
  • 25
    • 84880310548 scopus 로고    scopus 로고
    • Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials
    • Wolchok, J. D., J. S. Weber, M. Maio, B. Neyns, K. Harmankaya, K. Chin, et al. 2013. Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials. Ann. Oncol. 24:2174-2180.
    • (2013) Ann. Oncol. , vol.24 , pp. 2174-2180
    • Wolchok, J.D.1    Weber, J.S.2    Maio, M.3    Neyns, B.4    Harmankaya, K.5    Chin, K.6
  • 26
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
    • Wolchok, J. D., B. Neyns, G. Linette, S. Negrier, J. Lutzky, L. Thomas, et al. 2010. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 11:155-164.
    • (2010) Lancet Oncol. , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3    Negrier, S.4    Lutzky, J.5    Thomas, L.6
  • 27
    • 69949095926 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
    • Weber, J., J. A. Thompson, O. Hamid, D. Minor, A. Amin, I. Ron, et al. 2009. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin. Cancer Res. 15:5591-5598.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5591-5598
    • Weber, J.1    Thompson, J.A.2    Hamid, O.3    Minor, D.4    Amin, A.5    Ron, I.6
  • 28
    • 84890312714 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in metastatic or locally advanced, unresectable melanoma
    • abstr LBA24.
    • Schadendorf, D., F. S. Hodi, C. Robert, J. S. Weber, K. Margolin, and O. Hamid, et al. 2013. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in metastatic or locally advanced, unresectable melanoma. Eur. J. Cancer 49(Suppl. 3):abstr LBA24.
    • (2013) Eur. J. Cancer , vol.49
    • Schadendorf, D.1    Hodi, F.S.2    Robert, C.3    Weber, J.S.4    Margolin, K.5    Hamid, O.6
  • 29
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy in solid tumors: immune-related response criteria
    • Wolchok, J. D., A. Hoos, S. O'Day, J. S. Weber, O. Hamid, C. Lebbé, et al. 2009. Guidelines for the evaluation of immune therapy in solid tumors: immune-related response criteria. Clin. Cancer Res. 15:7412-7420.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3    Weber, J.S.4    Hamid, O.5    Lebbé, C.6
  • 30
    • 84856008240 scopus 로고    scopus 로고
    • Ipilimumab safety profile: summary of findings from completed trials in advanced melanoma
    • abstr 8583.
    • Ibrahim, R., D. Berman, de Pril V., R. W. Humphrey, T. Chen, and M. Messina, et al. 2011. Ipilimumab safety profile: summary of findings from completed trials in advanced melanoma. J. Clin. Oncol. 29(Suppl.):abstr 8583.
    • (2011) J. Clin. Oncol. , vol.29
    • Ibrahim, R.1    Berman, D.2    de Pril, V.3    Humphrey, R.W.4    Chen, T.5    Messina, M.6
  • 31
    • 84891046707 scopus 로고    scopus 로고
    • Time to onset and resolution of immune-related adverse events associated with ipilimumab therapy in patients with advanced melanoma
    • Presented at the Perspectives in Melanoma XIV; 17-18 September 2010; Amsterdam, The Netherlands. Abstract P-0004.
    • Dummer R ., M. Maio., O. Hamid, S. J. O'Day, J. Richards, and J. D. Wolchok, et al. 2010. Time to onset and resolution of immune-related adverse events associated with ipilimumab therapy in patients with advanced melanoma. Presented at the Perspectives in Melanoma XIV; 17-18 September 2010; Amsterdam, The Netherlands. Abstract P-0004.
    • (2010)
    • Dummer, R.M.M.1    Hamid, O.2    O'Day, S.J.3    Richards, J.4    Wolchok, J.D.5
  • 32
    • 84929871811 scopus 로고    scopus 로고
    • Ipilimumab US prescribing information: risk evaluation and mitigation strategy
    • (accessed on 12 September 2011).
    • Ipilimumab US prescribing information: risk evaluation and mitigation strategy. Available at http://www.yervoy.com/hcp/rems.aspx (accessed on 12 September 2011).
  • 33
    • 34147188180 scopus 로고    scopus 로고
    • Transient hypophysitis after cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade
    • Shaw, S. A., L. H. Camacho, I. E. McCutcheon, and S. G. Waguespack . 2007. Transient hypophysitis after cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. J. Clin. Endocrinol. Metab. 92:1201-1202.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1201-1202
    • Shaw, S.A.1    Camacho, L.H.2    McCutcheon, I.E.3    Waguespack, S.G.4
  • 35
    • 84990198858 scopus 로고    scopus 로고
    • Common terminology criteria for adverse events
    • Version 3.0, DCTD, NCI, NIH, DHHS. (accessed 12 September 2011).
    • Cancer Therapy Evaluation Program (CTEP). Common terminology criteria for adverse events, Version 3.0, DCTD, NCI, NIH, DHHS. Available at http://ctep.cancer.gov (accessed 12 September 2011).
  • 37
    • 85006190931 scopus 로고    scopus 로고
    • Phase 3 trial in subjects with metastatic melanoma comparing 3 mg/kg ipilimumab versus 10 mg/kg ipilimumab
    • ClinicalTrials.gov. . (accessed 12 March 2014).
    • ClinicalTrials.gov. 2012. Phase 3 trial in subjects with metastatic melanoma comparing 3 mg/kg ipilimumab versus 10 mg/kg ipilimumab. Available at http://www.clinicaltrials.gov/ct2/show/NCT01515189 (accessed 12 March 2014).
    • (2012)
  • 38
    • 33747878218 scopus 로고    scopus 로고
    • Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma
    • Maker, A. V., J. C. Yang, R. M. Sherry, S. L. Topalian, U. S. Kammula, R. E. Royal, et al. 2006. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. J. Immunother. 29:455-463.
    • (2006) J. Immunother. , vol.29 , pp. 455-463
    • Maker, A.V.1    Yang, J.C.2    Sherry, R.M.3    Topalian, S.L.4    Kammula, U.S.5    Royal, R.E.6
  • 39
    • 84877093633 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
    • Robert, C., D. Schadendorf, M. Messina, F. S. Hodi, S. O'Day, and MDX investigators. 2013. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin. Cancer Res. 19:2232-2239.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2232-2239
    • Robert, C.1    Schadendorf, D.2    Messina, M.3    Hodi, F.S.4    O'Day, S.5
  • 40
    • 85006215326 scopus 로고    scopus 로고
    • (accessed 10 December 2013).
    • National Comprehensive Cancer Network. Melanoma. Vol. 3.2014. Available at http://www.nccn.org/professionals/physician_gls/PDF/melanoma.pdf (accessed 10 December 2013).
    • (2014) Melanoma , vol.3
  • 42
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas, A., F. S. Hodi, M. Callahan, C. Konto, and J. Wolchok . 2013. Hepatotoxicity with combination of vemurafenib and ipilimumab. N. Engl. J. Med. 368:1365-1366.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 43
    • 84877043331 scopus 로고    scopus 로고
    • Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery
    • Mathew, M., M. Tam, P. A. Ott, A. C. Pavlick, S. C. Rush, B. R. Donahue, et al. 2013. Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery. Melanoma Res. 23:191-195.
    • (2013) Melanoma Res. , vol.23 , pp. 191-195
    • Mathew, M.1    Tam, M.2    Ott, P.A.3    Pavlick, A.C.4    Rush, S.C.5    Donahue, B.R.6
  • 44
    • 84864559660 scopus 로고    scopus 로고
    • Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival
    • Knisely, J. P., J. B. Yu, J. Flanigan, M. Sznol, H. M. Kluger, and V. L. Chiang . 2012. Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival. J. Neurosurg. 117:227-233.
    • (2012) J. Neurosurg. , vol.117 , pp. 227-233
    • Knisely, J.P.1    Yu, J.B.2    Flanigan, J.3    Sznol, M.4    Kluger, H.M.5    Chiang, V.L.6
  • 45
    • 84904216679 scopus 로고    scopus 로고
    • Ipilimumab and radiation therapy for melanoma brain metastases
    • Silk, A. W., M. F. Bassetti, B. T. West, C. I. Tsien, and C. D. Lao . 2013. Ipilimumab and radiation therapy for melanoma brain metastases. Cancer Med. 2:899-906.
    • (2013) Cancer Med. , vol.2 , pp. 899-906
    • Silk, A.W.1    Bassetti, M.F.2    West, B.T.3    Tsien, C.I.4    Lao, C.D.5
  • 47
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
    • Margolin, K., M. S. Ernstoff, O. Hamid, D. Lawrence, D. McDermott, I. Puzanov, et al. 2012. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 13:459-465.
    • (2012) Lancet Oncol. , vol.13 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3    Lawrence, D.4    McDermott, D.5    Puzanov, I.6
  • 48
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong, H., S. E. Strome, D. R. Salomao, H. Tamura, F. Hirano, D. B. Flies, et al. 2002. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8:793-800.
    • (2002) Nat. Med. , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 49
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel, T. J., S. Wei, H. Dong, X. Alvarez, P. Cheng, P. Mottram, et al. 2003. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9:562-567.
    • (2003) Nat. Med. , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 50
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson, R. H., S. M. Kuntz, B. C. Leibovich, H. Dong, C. M. Lohse, W. S. Webster, et al. 2006. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res. 66:3381-3385.
    • (2006) Cancer Res. , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3    Dong, H.4    Lohse, C.M.5    Webster, W.S.6
  • 51
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer, J. R., C. G. Drake, I. Wollner, J. D. Powderly, J. Picus, W. H. Sharfman, et al. 2010. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28:3167-3175.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3    Powderly, J.D.4    Picus, J.5    Sharfman, W.H.6
  • 52
    • 13444270323 scopus 로고    scopus 로고
    • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
    • Hirano, F., K. Kaneko, H. Tamura, H. Dong, S. Wang, M. Ichikawa, et al. 2005. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65:1089-1096.
    • (2005) Cancer Res. , vol.65 , pp. 1089-1096
    • Hirano, F.1    Kaneko, K.2    Tamura, H.3    Dong, H.4    Wang, S.5    Ichikawa, M.6
  • 54
    • 84895904745 scopus 로고    scopus 로고
    • Mitigating the toxic effects of anticancer immunotherapy
    • Ganghadar, T. C., and R. H. Vonderheide . 2014. Mitigating the toxic effects of anticancer immunotherapy. Nat. Rev. Clin. Oncol. 11:91-99.
    • (2014) Nat. Rev. Clin. Oncol. , vol.11 , pp. 91-99
    • Ganghadar, T.C.1    Vonderheide, R.H.2
  • 55
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian, S. L., M. Sznol, D. F. McDermott, H. M. Kluger, R. D. Carvajal, W. H. Sharfman, et al. 2014. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 32:1020-1030.
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 56
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid, O., C. Robert, A. Daud, F. S. Hodi, W. J. Hwu, R. Kefford, et al. 2013. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369:134-144.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 57
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
    • Robert, C., A. Ribas, J. D. Wolchok, F. S. Hodi, O. Hamid, R. Kefford, et al. 2014. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 384:1109-1117.
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6
  • 58
    • 84907543029 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL)
    • abstr LBA9000.
    • Ribas, A., F. S. Hodi, R. Kefford, O. Hamid, A. Daud, and J. D. Wolchok, et al. 2014. Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL). J. Clin. Oncol. 32(Suppl. 5):abstr LBA9000.
    • (2014) J. Clin. Oncol. , vol.32
    • Ribas, A.1    Hodi, F.S.2    Kefford, R.3    Hamid, O.4    Daud, A.5    Wolchok, J.D.6


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